High-performance thin-layer chromatographic fingerprint method for the detection of sennosides in <i>Cassia senna</i> L. and <i>Cassia angustifolia</i> Vahl

Meier, Nadja; Meier, Beat; Peter, Samuel; Wolfram, Evelyn

doi:10.1556/1006.2017.30.4.1

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…Before being put into 2 g suppository molds ، the mixture was cooled to a temperature of 55-60 °C for all suppositories. Before further examination or usage ، they were stored in their molds in the refrigerator and allowed to harden at room temperature in a desiccator for at least 24 hours (28) . In vitro dissolution study Ph.…”

Section: Suppository Preparationmentioning

confidence: 99%

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Preparation and Evaluation of Azithromycin as Rectal Suppository to Treat Bacterial Infection of COVID-19

Khalil,

Hameed,

Basil Hanna

2023

IJPS

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In this study azithromycin was formulated for the first time as co-amorphous system suppository system to achieve the maximum bioavailability and to avoid the side effect that might be with oral route which is associated with this drug during treatment of Corona virus secondary bacterial infection. In this study the co-amorphous system was characterized by Differential Scanning Calorimetry (DSC), Powder X-ray Diffractometry (PXRD) and Fourier Transform Infrared Spectroscopy (FTIR). Eight different suppository formulas were prepared, these formulas were subjected to the dissolution test by Ph. Eur. Apparatus I (basket apparatus). The antibacterial activity was measured by the agar well-diffusion method. The results revealed the formation co-amorphous system. The formula in co-amorphous system with glycerin showed the best release for both azithromycin and curcumin. The combination and co-amorphous system showed double value of zone of inhibition rather than the drugs alone. This study will be interested in drugs company to find alternative rout of drug administration for serious infection that associated with GIT symptoms.

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Section: Suppository Preparationmentioning

confidence: 99%

“…After S.E ، the wavenumber of the peak was 1724 cm -1 . The shift from 1716 cm -1 to 1724 cm -1 in the C=O region that might indicates the formation of hydrogen bonding might be due to amorphous formation (28) . (39) .…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

Preparation and Evaluation of Azithromycin as Rectal Suppository to Treat Bacterial Infection of COVID-19

Khalil,

Hameed,

Basil Hanna

2023

IJPS

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“…contains several flavonoids, namely quercimeritrin, scutellarein, and rutin, that show anticancer, antioxidant, and antimicrobial properties [1]. Novel identification methods for pharmacopoeial Senna species include high-performance thin-layer chromatography [14], as well as scanning electron microscopy method for authentication of C. angustifolia Vahl. [20].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Granulation Process Effect on Morpho-Anatomical Features and Biologically Active Substances Composition of Senna Leaves

Trifonova¹

2021

FARMACIA

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Cassia senna L. and Cassia angustifolia Vahl. leaves and their preparations are widely acknowledged herbal drugs. Recent development of a novel dosage form -cut-pressed granules -enhances convenience of use in a home setting. However, manufacturing of cut-pressed granules is feasible only if the quality of the material doesn't decrease during granulation. The aim of the study was to assess the possible changes in identification parameters and in the composition of biologically active substances in Senna leaves after processing. It was shown that TLC chromatographic profiles of the herbal drug remain unchanged. Spectrophotometric assessment confirmed that the anthracene aglycones content of the herbal material was also not affected by granulation. It can be concluded that the quality of cut-pressed granules obtained from Senna leaves is not inferior compared to the raw material. RezumatCassia senna L. și Cassia angustifolia Vahl. sunt cunoscute pentru efectele lor biologice. Dezvoltarea recentă a unei noi forme de dozare, granule presate, tăiate, îmbunătățește complianța. Scopul studiului a fost de a evalua posibilele modificări ale parametrilor de identificare și ale compoziției substanțelor biologic active din frunzele de Senna după procesare. Rezultatele au arătat că profilurile cromatografice TLC rămân neschimbate. Evaluarea spectrofotometrică a conținutului de agliconi antracenici a confirmat calitatea granulelor.

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HPLC-DAD, GC–MS, UHPLC-Q-TOF/MS2, ICP-MS and FT-NIR combined with the chemometrics explain seasonal variation in Cassia senna L. leaves from the coast of Red Sea in Sudan

Tahir,

Hashim,

Arslan

et al. 2023

South African Journal of Botany

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High-performance thin-layer chromatographic fingerprint method for the detection of sennosides in Cassia senna L. and Cassia angustifolia Vahl

Cited by 3 publications

References 3 publications

Preparation and Evaluation of Azithromycin as Rectal Suppository to Treat Bacterial Infection of COVID-19

Preparation and Evaluation of Azithromycin as Rectal Suppository to Treat Bacterial Infection of COVID-19

Assessment of the Granulation Process Effect on Morpho-Anatomical Features and Biologically Active Substances Composition of Senna Leaves

HPLC-DAD, GC–MS, UHPLC-Q-TOF/MS2, ICP-MS and FT-NIR combined with the chemometrics explain seasonal variation in Cassia senna L. leaves from the coast of Red Sea in Sudan

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