High-performance thin-layer chromatographic determination of satranidazole in its dosage form

Lalla, J. K.; Hamrapurkar, Purnima D.; Anu., R; Wadhwa, Tarun

doi:10.1556/jpc.16.2003.6.8

Cited by 5 publications

(6 citation statements)

References 3 publications

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“…In individual methods effect determined are equal and with no significant differences at 95% confidence level as observed F0.05 (2, 12) < tabulated F0.05 (2,12) which was further supported by the difference between any two methods observations are always lower than the critical difference value calculated. But individual solvents effect determined are not equal and with significant differences at 95% confidence level as observed F0.05 (6, 12) > tabulated F0.05 (6,12) [21]. Critical difference value is used to compare with all pairs of samples to sample total and the difference between DDW and acetonitrile was found to be greater than the critical difference value.…”

Section: Discussionmentioning

confidence: 91%

“…Several study showed that validation and estimation of STZ may be done using high-performance liquid chromatography (HPLC) [4], high-performance thin layer chromatography (HPTLC) [5,6] colorimetric method after chemical derivatization [7,8], and UVspectrophotometric methods both in combination with ofloxacin or gatifloxacin or alone [9,10]. Absence of sufficient experimental data of UVspectrophotometric methods for quantitative estimations of satranidazole (STZ) in pharmaceutical formulation using different classes of solvents influence to perform the present study.…”

Section: Introductionmentioning

confidence: 99%

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Improved comprehensive analytical method for assessment of satranidazole in drug and product

Mazumder

Mahanti

Majumdar³

et al. 2020

Futur J Pharm Sci

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Background: The aim of the present investigation was to improve comprehensive analytical method for the assessment of satranidazole in drug and product with simple, economic, sensitive, and reproducible spectrophotometric method. The drug was analyzed in three different methods by using various solvents where satranidazole (STZ) showed different absorbance maxima (s) and sharp peaks in the first order derivative spectra. Beer's law range, correlation coefficient, apparent molar absorptivity, etc., were determined for each solvent using all the three methods. Results: All the results of analysis were found to be satisfactory which was validated statistically for various parameters and by performing recovery studies in accordance with international conference on harmonization (ICH) guidelines. The developed methods were also compared statistically using one way analysis of variance (ANOVA). Conclusion: Three different spectrophotometric methods were developed for satranidazole (STZ) using various inorganic and organic solvents. The analytical methods are found to be simple, sensitive, rapid, specific, and economic, and it can be conveniently employed for the routine analysis, quality control. The sample recoveries from the formulation were in good agreement with its respective label claim.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Improved comprehensive analytical method for assessment of satranidazole in drug and product

Mazumder

Mahanti

Majumdar³

et al. 2020

Futur J Pharm Sci

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“…1) is a nitroimidazole derivative and widely used as antiprotozoal agent in the treatment of amoebiasis [1]. Literature survey revealed that few analytical methods have been developed for the determination of satranidazole in pharmaceutical formulations and biological materials include spectrophotometric [2][3][4][5], HPLC [6][7][8][9][10][11], HPTLC [12,13] and electron-capture gas chromatographic determination [14]. Previously reported spectrophotometric methods [2,4] for the determination of satranidazole in pharmaceutical formulations and biological materials were complicated and not economical.…”

Section: Introductionmentioning

confidence: 99%

Determination of Satranidazole through Ion-Associative Complex Reaction

Kumar¹,

Nadh

Kishore³

et al. 2019

Asian J. Org. Med. Chem.

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A simple, selective, accurate and low-cost spectrophotometric method has been described for determination of satranidazole in bulk and pharmaceutical formulations. The developed method involves the formation of chloroform extractable colored ion-association complex of satranidazole with Tropaeolin OOO (TPooo). The extracted colored complex showed absorbance maximum at wavelength 484 nm and obeying Beer′s law in the concentration 4-20 μg mL-1 with the correlation coeffiecent of 0.9998. The results of statistical analysis of the proposed method reveals high accuracy and good precession. Thus, the proposed method can be used commercially for the determination of satranidazole in bulk and pharmaceutical formulations.

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“…The structure of active moiety is mentioned in Figure.1. Literature survey revealed an electron-capture gas chromatographic assays in blood 2 , spectrophotometric methods 3,4,5,6 , HPTLC methods 7,8 and HPLC methods 9,10,11,12 in pharmaceutical dosage form for estimation of Satranidazole individually as well as in combination with Ofloxacin. Spectrophotometric method is generally preferred especially by small-scale industries as the cost of the equipment is less and the maintenance problems are minimal.…”

Section: Introductionmentioning

confidence: 99%

Development of a Simple Uv-Spectrophotometric Assay Method for Satranidazole and Study of Its Degradation Profile

Agrahari¹,

Bajpai²,

Nanda³

2016

Int. Res. J. Pharm.

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A simple, selective, rapid, precise, economical, reproducible and stability-indicating UV spectrophotometric method has been developed and validated for determination of Satranidazole in pure form and pharmaceutical dosage form. From solvent effect studies and the spectral behaviour of Satranidazole, methanol was selected as solvent. The UV spectrum was scanned between 200 to 400 nm and 318 nm was selected as maximum wavelength for absorption. Beer's law was obeyed in the concentration range of 2-30 µg /mL. The regression coefficient was 0.999. The method was validated for accuracy, precision, specificity and robustness, in accordance with ICH guidelines. Recovery studies gave satisfactory results indicating that none of common additives and excipients or the degraded impurities interfere in the assay method. Statistical analysis proved the method was precise, reproducible, selective, specific, and accurate for analysis of Satranidazole. Stability testing study includes the effect of oxidation, photolysis and susceptibility to hydrolysis across a wide range of pH values. The wide linearity range, accuracy and easy preparation of diluent imply the method is suitable for routine quantification of Satranidazole in the quality control of bulk forms and pharmaceutical dosage forms with high precision and accuracy.

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High-performance thin-layer chromatographic determination of satranidazole in its dosage form

Cited by 5 publications

References 3 publications

Improved comprehensive analytical method for assessment of satranidazole in drug and product

Improved comprehensive analytical method for assessment of satranidazole in drug and product

Determination of Satranidazole through Ion-Associative Complex Reaction

Development of a Simple Uv-Spectrophotometric Assay Method for Satranidazole and Study of Its Degradation Profile

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