High performance photosensitizers with aggregation-induced emission for image-guided photodynamic anticancer therapy

Wu, Wenbo; Mao, Duo; Xu, Shidang; Ji, Shenglu; Hu, Fang; Ding, Dan; Kong, Deling; Liu, Bin

doi:10.1039/c7mh00469a

Cited by 137 publications

(129 citation statements)

References 27 publications

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“…This is because the aggregation of traditional hydrophobic PSs often causes fluorescence quenching with reduced singlet oxygen ( 1 O 2 ) generation in aqueous media, which significantly hampers their bacteria‐killing efficacy . To address this issue, PSs with aggregation‐induced emission (AIE PS) have been developed to show bright fluorescence and excellent 1 O 2 production in the aggregate state, or even as nanoparticles dispersed in aqueous media …”

Section: Methodsmentioning

confidence: 99%

Membrane‐Anchoring Photosensitizer with Aggregation‐Induced Emission Characteristics for Combating Multidrug‐Resistant Bacteria

Chen

et al. 2019

Angewandte Chemie

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Traditional photosensitizers (PSs) show reduced singlet oxygen (1O2) production and quenched fluorescence upon aggregation in aqueous media, which greatly affect their efficiency in photodynamic therapy (PDT). Meanwhile, non‐targeting PSs generally yield low efficiency in antibacterial performance due to their short lifetimes and small effective working radii. Herein, a water‐dispersible membrane anchor (TBD‐anchor) PS with aggregation‐induced emission is designed and synthesized to generate 1O2 on the bacterial membrane. TBD‐anchor showed efficient antibacterial performance towards both Gram‐negative (Escherichia coli) and Gram‐positive bacteria (Staphylococcus aureus). Over 99.8 % killing efficiency was obtained for methicillin‐resistant S. aureus (MRSA) when they were exposed to 0.8 μm of TBD‐anchor at a low white light dose (25 mW cm−2) for 10 minutes. TBD‐anchor thus shows great promise as an effective antimicrobial agent to combat the menace of multidrug‐resistant bacteria.

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Section: Methodsmentioning

confidence: 99%

Membrane‐Anchoring Photosensitizer with Aggregation‐Induced Emission Characteristics for Combating Multidrug‐Resistant Bacteria

Chen

et al. 2019

Angewandte Chemie

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“…To realize AIE PSs with far red (FR)/near infrared (NIR) emission and effective 1 O 2 production under white light irradiation, a D (donor)-A' (auxiliary acceptor)-p (p spacer)-A (real acceptor) structure was applied to design. [13] A PS with a terminal acetylene group (Supporting Information, Scheme S1) was synthesized, which allows for subsequent PEG conjugation to yield an amphiphilic polymer containing a terminal -N 3 group (Scheme S1). In aqueous media, the amphiphilic polymer forms nanoparticles with -N 3 exposed for further conjugation with an antisense OSA targeting Bcl-2 mRNA, named as Bcl-2 antisense OSA, to form the coreshell SNA.…”

Section: Resultsmentioning

confidence: 99%

Light‐Induced Self‐Escape of Spherical Nucleic Acid from Endo/Lysosome for Efficient Non‐Cationic Gene Delivery

Shi

Duan

et al. 2020

Angewandte Chemie

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Developing non-cationic gene carriers and achieving efficient endo/lysosome escape of functional nucleic acids in cytosol are two major challenges faced by the field of gene delivery. Herein, we demonstrate the concept of self-escape spherical nucleic acid (SNA) to achieve light controlled noncationic gene delivery with sufficient endo/lysosome escape capacity. In this system, Bcl-2 antisense oligonucleotides (OSAs) were conjugated onto the surface of aggregationinduced emission (AIE) photosensitizer (PS) nanoparticles to form core-shell SNA. Once the SNAs were taken up by tumor cells, and upon light irradiation, the accumulative 1 O 2 produced by the AIE PSs ruptured the lysosome structure to promote OSA escape. Prominent in vitro and in vivo results revealed that the AIE-based core-shell SNA could downregulate the anti-apoptosis protein (Bcl-2) and induce tumor cell apoptosis without any transfection reagent.

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“…This unique property of AIEgen has been applied in various fields, basic research as well as industries [16]. Recently, it showcased in a few cases that the photophysical properties of AIEgens are manageable, like D-A type fluorophores, by introducing electron donating and accepting moieties to the AIEgen backbones through π-conjugation [17][18][19]. However, the synthesis, photophysical properties, and practical applications of the articulated structures (no π-conjugation), between D-A type fluorophore and AIEgen have yet to be fully investigated.…”

Section: Introductionmentioning

confidence: 99%

Articulated Structures of D-A Type Dipolar Dye with AIEgen: Synthesis, Photophysical Properties, and Applications

Kim

Hur

et al. 2020

Materials

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Articulated structures of naphthalene-based donor (D)-acceptor (A) type dipolar dye and aggregation-induced emission luminogen (AIEgen) based on tetraphenylethylene (TPE) were synthesized, and their photophysical properties were analyzed for the first time. There are many fluorophore backbones, which have dipolar structure and AIEgen. However, there has been neither property analysis nor research that closely articulates DA and AIE through non-conjugation linker. We have therefore prepared two representative fluorophores; DA-AIE series (DA-AIE-M and DA-AIE-D), and characterized their UV/vis absorption and emission properties with quantum chemical calculations. In addition, we utilized the unique photophysical properties of DA-AIE-D for monitoring a trace of dimethyl sulfoxide (DMSO) in aqueous media, including real water samples.

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High performance photosensitizers with aggregation-induced emission for image-guided photodynamic anticancer therapy

Abstract: A series of D–A′–π–A type photosensitizers were designed and synthesized to show strong aggregation-induced far red and near infrared emission and very effective 1O2 generation simultaneously, and have been successfully used for image-guided photodynamic anticancer therapy.

Cited by 137 publications

References 27 publications

Membrane‐Anchoring Photosensitizer with Aggregation‐Induced Emission Characteristics for Combating Multidrug‐Resistant Bacteria

Membrane‐Anchoring Photosensitizer with Aggregation‐Induced Emission Characteristics for Combating Multidrug‐Resistant Bacteria

Light‐Induced Self‐Escape of Spherical Nucleic Acid from Endo/Lysosome for Efficient Non‐Cationic Gene Delivery

Articulated Structures of D-A Type Dipolar Dye with AIEgen: Synthesis, Photophysical Properties, and Applications

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