High-Performance Liquid Chromatography of Clindamycin Antibiotics using Tris(Bipyridine)- ruthenium(III) Chemiluminescence Detection

Targove, Margaret A.; Danielson, Neil D.

doi:10.1093/chromsci/28.10.505

Cited by 59 publications

(20 citation statements)

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“…The oxidation-reduction reaction mechanism between Ru(bpy)3 2+ and tertiary amines (Scheme 1) has been investigated by many researchers. [32][33][34] This ECL reaction mechanism has been used for the determination of tertiary aliphatic 35,36 and alicyclic amines, 37 amino acids, 38 and pharmaceutical products, such as erythromycin, 39 clindomycin, 40 and antihistamines. 41 This ECL reagent will, in general, react best with tertiary, then secondary, and finally primary amines.…”

Section: +mentioning

confidence: 99%

Column-Switching HPLC Determination of Mexiletine Using Tris(bipyridine)ruthenium(III) Electrogenerated Chemiluminescence and Precolumn Derivatization with Divinylsulfone

2010

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Section: +mentioning

confidence: 99%

Column-Switching HPLC Determination of Mexiletine Using Tris(bipyridine)ruthenium(III) Electrogenerated Chemiluminescence and Precolumn Derivatization with Divinylsulfone

2010

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“…electrochemical (8), UV (9)(10)(11)(12), MS (13)(14)(15) and chemiluminescence (CL) (16). Compared with these techniques, the combination of CL and a flow-injection (FI) method (FI-CL) provides many advantages for pharmaceutical analyses, such as high sensitivity, high selectivity, small chemical consumption, cost effectiveness and simple sample preparation and instrumentation (17,18), and has been frequently used for this purpose in recent years (19).…”

Section: Clindamycin [7(s)-chloro-7-deoxylincomycin] Is An Antibioticmentioning

confidence: 99%

Ultrasensitive assay of clindamycin in medicine and bio‐fluids with chemiluminescence detection

Wei

Dang

2007

Luminescence

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A simple chemiluminescence (CL) method using flow injection has been developed for the determination of clindamycin, based on the inhibitory effect of clindamycin on the CL generated from the luminol-K(3)Fe(CN)(6) system in alkaline medium. It was found that the decrement of CL intensity was linear with the logarithm of clindamycin concentration over the range 0.7-1000 ng/mL. The detection limit was 0.2 ng/mL with a relative standard deviation (RSD) of <5.0% (n = 7). At a flow rate of 3.0 mL/min, a complete analytical process could be performed within 0.5 min, including sampling and washing. The proposed procedure was applied successfully to the determination of clindamycin in pharmaceutical preparations and human urine without pretreatment.

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“…[8][9][10][11][12] As shown in Fig.1, PCP is one of alicyclic tertiary amines. Thus, we tried to expand the application of the system to the assay of PCP and its metabolites.…”

Section: Conditionsmentioning

confidence: 99%

Simultaneous Determination of Phencyclidine and Its Metabolites in Rat Urine by High-Performance Liquid Chromatography

1998

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High-Performance Liquid Chromatography of Clindamycin Antibiotics using Tris(Bipyridine)- ruthenium(III) Chemiluminescence Detection

Cited by 59 publications

References 0 publications

Column-Switching HPLC Determination of Mexiletine Using Tris(bipyridine)ruthenium(III) Electrogenerated Chemiluminescence and Precolumn Derivatization with Divinylsulfone

Column-Switching HPLC Determination of Mexiletine Using Tris(bipyridine)ruthenium(III) Electrogenerated Chemiluminescence and Precolumn Derivatization with Divinylsulfone

Ultrasensitive assay of clindamycin in medicine and bio‐fluids with chemiluminescence detection

Simultaneous Determination of Phencyclidine and Its Metabolites in Rat Urine by High-Performance Liquid Chromatography

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