High-performance liquid chromatography coupled to direct analysis in real time mass spectrometry: Investigations on gradient elution and influence of complex matrices on signal intensities

Beißmann, Susanne; Buchberger, Wolfgang; Hertsens, R.; Klampfl, Christian W.

doi:10.1016/j.chroma.2011.05.092

Cited by 38 publications

(26 citation statements)

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“…Ionisation of the organics within the sample without the need for a vacuum presents the possibility of a whole new set of applications for direct mass spectrometry. Within the wider scientific community DART-MS is already being combined with separation techniques such as thin layer chromatography (TLC), gas chromatography (GC), HPLC and tandem mass spectroscopy (91)(92)(93)(94)(95) and these techniques all have the potential to find applications in the analysis of archaeological organic residues.…”

Section: New Mass Spectrometric Techniquesmentioning

confidence: 99%

Organic Residues in Archaeology: The Highs and Lows of Recent Research

Steele

2013

ACS Symposium Series

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The analysis of organic residues from archaeological materials has become increasingly important to our understanding of ancient diet, trade and technology. Residues from diverse contexts have been retrieved and analysed from the remains of food, medicine and cosmetics to hafting material on stone arrowheads, pitch and tar from shipwrecks, and ancient manure from soils. Research has brought many advances in our understanding of archaeological, organic residues over the past two decades. Some have enabled very specific and detailed interpretations of materials preserved in the archaeological record. However there are still areas where we know very little, like the mechanisms at work during the formation and preservation of residues, and areas where each advance produces more questions rather than answers, as in the identification of degraded fats. This chapter will discuss some of the significant achievements in the field over the past decade and the ongoing challenges for research in this area.1341280_File000001_20903114.docPrinted 7/19/2013 2

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Section: New Mass Spectrometric Techniquesmentioning

confidence: 99%

Organic Residues in Archaeology: The Highs and Lows of Recent Research

Steele

2013

ACS Symposium Series

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“…20,21) This may be the long-sought-after solution to LC/MS analysis using the same buffer systems that are familiar to chromatographers.…”

Section: Resultsmentioning

confidence: 99%

What Is the Opposite of Pandora’s Box? Direct Analysis, Ambient Ionization, and a New Generation of Atmospheric Pressure Ion Sources

Cody

2013

Mass Spectrometry

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The introduction of DART and DESI sources approximately seven years ago led to the development of a new series of atmospheric pressure ion sources referred to as "ambient ionization" sources. These fall into two major categories: spray techniques like DESI or plasma techniques like DART. The selectivity of "direct ionization," meaning analysis without chromatography and with little or no sample preparation, depends on the mass spectrometer selectivity. Although high resolution and tandem mass spectrometry are valuable tools, rapid and simple sample preparation methods can improve the utility of ambient ionization methods. The concept of ambient ionization has led to the realization that there are many more ways to form ions than might be expected. An interesting example is the use of a flint-and-steel spark source to generate ions from compounds such as phenolphthalein and Gramicidin S.

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“…Klampfl [10,11] has recently reported an ion source where the mobile phase streaming from an LC column was transported through a capillary to a DART plasma plume for ionization in the form of a drop hanging from the transport capillary, or as a continuous liquid jet, depending on the liquid flow rate and capillary diameter. Liu et al [12], on the other hand, used a pneumatic sprayer to form aerosols from a CE effluent prior to DART ionization.…”

Section: Introductionmentioning

confidence: 99%

Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis

Kaylor

Dwivedi

Pittman

et al. 2014

J. Am. Soc. Mass Spectrom.

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A new ion generation method, named plasma-spray ionization (PLASI) for direct analysis of liquid streams, such as in continuous infusion experiments or liquid chromatography (LC), is reported. PLASI addresses many of the analytical limitations of electrospray ionization (ESI) and has potential for real time process stream analysis and reaction monitoring under atmospheric conditions in non-ESI friendly scenarios. In PLASI-mass spectrometry (MS), the liquid stream is pneumatically nebulized and partially charged at low voltages; the resultant aerosol is thus entrained with a gaseous plasma plume from a distal glow discharge prior to MS detection. PLASI-MS not only overcomes ESI-MS limitations but also generates simpler mass spectra with minimal adduct and cluster formation. PLASI utilizes the atomization capabilities of an ESI sprayer operated below the ESI threshold to generate gas-phase aerosols that are then ionized by the plasma stream. When operated at or above the ESI threshold, ionization by traditional ESI mechanisms is achieved. The multimodal nature of the technique enables readily switching between plasma and ESI operation. It is expected that PLASI will enable analyzing a wide range of analytes in complex matrices and less-restricted solvent systems, providing more flexibility than that achievable by ESI alone.

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High-performance liquid chromatography coupled to direct analysis in real time mass spectrometry: Investigations on gradient elution and influence of complex matrices on signal intensities

Cited by 38 publications

References 40 publications

Organic Residues in Archaeology: The Highs and Lows of Recent Research

Organic Residues in Archaeology: The Highs and Lows of Recent Research

What Is the Opposite of Pandora’s Box? Direct Analysis, Ambient Ionization, and a New Generation of Atmospheric Pressure Ion Sources

Plasma-Spray Ionization (PLASI): A Multimodal Atmospheric Pressure Ion Source for Liquid Stream Analysis

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