High-Performance Liquid Chromatography Analysis of Spectrin Oligomerization

Löfvenberg, Lars; Backman, Lars

doi:10.1006/abio.2001.5036

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Cd4 Is the Receptor For Salp151

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2006

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“…2D). The overlapping peaks were resolved by Gaussian fit analysis (15), which showed the elution volume of the complex to be 26.38 ml, compared with 27.53 ml for the sCD4 peak (Fig. 2D).…”

Section: Cd4 Is the Receptor For Salp15mentioning

confidence: 99%

Cutting Edge: CD4 Is the Receptor for the Tick Saliva Immunosuppressor, Salp15

Garg¹,

Juncadella

Ramamoorthi

et al. 2006

The Journal of Immunology

112

127

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Salp15 is an Ixodes scapularis salivary protein that inhibits CD4+ T cell activation through the repression of TCR ligation-triggered calcium fluxes and IL-2 production. We show in this study that Salp15 binds specifically to the CD4 coreceptor on mammalian host T cells. Salp15 specifically associates through its C-terminal residues with the outermost two extracellular domains of CD4. Upon binding to CD4, Salp15 inhibits the subsequent TCR ligation-induced T cell signaling at the earliest steps including tyrosine phosphorylation of the Src kinase Lck, downstream effector proteins, and lipid raft reorganization. These results provide a molecular basis to understanding the immunosuppressive activity of Salp15 and its specificity for CD4+ T cells.

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“…2D). The overlapping peaks were resolved by Gaussian fit analysis (15), which showed the elution volume of the complex to be 26.38 ml, compared with 27.53 ml for the sCD4 peak (Fig. 2D).…”

Section: Cd4 Is the Receptor For Salp15mentioning

confidence: 99%