High-performance liquid chromatographic method for the determination of amineptine and its main metabolite in human plasma

Nicot, G; Lachâtre, Gérard; Gonnet, C.; Valette, Jean-Paul; Merle, Louis; Nouaille, Y.; Bromet, Norbert

doi:10.1016/s0378-4347(00)80890-7

Cited by 11 publications

(5 citation statements)

References 6 publications

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“…Amineptine and its principal metabolite were assayed in plasma by the HPLC technique of Nicot involving inverse phase polarity and ion-pairing (Nicot et al, 1984). The products were extracted as ion-pairs in a heptane-octanol-tetraheptyl-ammonium bromide mixture (98/2/0.5 ; vol/vol/wt).…”

Section: Assay Methodsmentioning

confidence: 99%

Single‐dose Pharmacokinetics of Amineptine and of Its Main Metabolite in Healthy Young Adults

Lachâtre

Piva

Riche³

et al. 1989

Fundamemntal Clinical Pharma

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The pharmacokinetics of the tricyclic antidepressant amineptine (Survector) and its main metabolite were studied in 12 young healthy adults (6 men, 6 women; mean age 35.8 yr). Plasma samples were taken over 24 h following a single oral dose of 100 mg amineptine chloryhdrate. Plasma levels of both compounds were determined by means of high performance liquid chromatography. Amineptine was rapidly absorbed. Mean peak plasma concentrations of amineptine and its metabolite occurred 1 h and 1.5 h, respectively, after product administration. The mean apparent volume of distribution was large: 2.4 l.kg-1. Elimination was rapid; the mean half-lives of the 2 compounds were short: 0.8 h for amineptine and 2.5 h for the metabolite. The mean apparent plasma clearance of amineptine was high (124.8 l.h-1). When the results were adjusted for body weight and surface area, no significant difference in pharmacokinetic parameters was found between men and women. Given its pharmacokinetic characteristics there is no risk of amineptine accumulation and thus it is a particularly easy drug to manage. A standard dosage of amineptine was defined for use in healthy young adults.

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Section: Assay Methodsmentioning

confidence: 99%

Single‐dose Pharmacokinetics of Amineptine and of Its Main Metabolite in Healthy Young Adults

Lachâtre

Piva

Riche³

et al. 1989

Fundamemntal Clinical Pharma

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“…Three electro-analytical methods based on DPP, SWP and ASV had been developed. These methods are quick and relatively cheap to operate compared with alternative HPLC methods [5][6][7]. They are suitable for routine analysis in quality control laboratories, to be applied for the analysis of TIA in pure form and in tablets.…”

Section: Resultsmentioning

confidence: 99%

“…Spectrofluorimetric assays have been used for the analysis of TIA in tablets [3,4]. Few chromatographic studies concerned with the quantification of TIA simultaneously with its metabolites in human plasma have been reported [5][6][7]. The analytical reviews of TIA revealed no voltammetric studies concerning the reduction at the mercury electrode has been reported.…”

Section: Introductionmentioning

confidence: 99%

Differential pulse, square wave and adsorptive stripping voltammetric quantification of tianeptine in tablets

Gazy

Mahgoub

Khamis

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

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“…2) Various methods have been reported in the literature for the analysis of Tia including spectrofluorimetry 3,4) and voltametry. 5) Reverse-phase high performance liquid chromatography/ fluorescence detection, 6) UV detection 7,8) and gas chromatography 9) are also reported for determination of Tia from human biological fluids.…”

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confidence: 99%

“…According to the literature research, [3][4][5][6][7][8][9] Tia has been ionpair associated with bromophenol blue (BPB), bromocresol green (BCG), bromothymol blue (BTB), methyl orange (MO) and determined by a spectrophotometric method for the first time. The proposed method for tianeptine determination has many advantages over other analytical methods due to its rapidity, lower cost and environmental safety.…”

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A New Spectrophotometric Method for the Determination of Tianeptine in Tablets Using Ion-Pair Reagents

Ulu

Aydoğmuş

2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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1635Tianeptine (Tia); 7- [(3-chloro-6,11]-dihydro-6-methyldibenzo [c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,Sdioxide ( Fig. 1) 1) is an antidepressant agent with a novel neurochemical profile. It increases serotonin (5-hydroxytryptamine; 5-HT) uptake in the brain (in contrast to most antidepressant agents) and reduces stress-induced atrophy of neuronal dendrites. Like the selective serotonin reuptake inhibitors (SSRIs) and in contrast with most tricyclic antidepressant agents, tianeptine does not appear to be associated with adverse cognitive, psychomotor, sleep, cardiovascular or bodyweight effects and has a low propensity for abuse. 2)Various methods have been reported in the literature for the analysis of Tia including spectrofluorimetry 3,4) and voltametry. 5)Reverse-phase high performance liquid chromatography/ fluorescence detection, 6) UV detection 7,8) and gas chromatography 9) are also reported for determination of Tia from human biological fluids.According to the literature research, 3-9) Tia has been ionpair associated with bromophenol blue (BPB), bromocresol green (BCG), bromothymol blue (BTB), methyl orange (MO) and determined by a spectrophotometric method for the first time. The proposed method for tianeptine determination has many advantages over other analytical methods due to its rapidity, lower cost and environmental safety. Unlike the gas chromatographic and HPLC procedures, the instrument is simple and is not costly. All statistical values (percentage recoveries, RSD, confidence limits of the slope and intercept, LOD and LOQ) were within the acceptable limits. Economically, all the analytical reagents are inexpensive and available in any analytical laboratory. The proposed method reports a new for the determination of Tia in pharmaceuticals.The present paper thus describes fast, simple, sensitive and validated spectrophotometric method for the determination of Tia. ExperimentalMaterials Tia and 12.5 mg tablets (Stablon ® ) were gifts from Servier (Istanbul, Turkey). BPB, BCG, BTB, and MO were purchased from Merck (Darmstadt, Germany). All chemicals and solvents used were of analytical and pharmaceutical grades. Water was always distilled.Solutions A stock solution of 1.0 mg ml Ϫ1 was prepared by dissolving 100 mg of Tia in 100 ml of water. Working standard solutions of Tia of 100 mg ml Ϫ1 were prepared by appropriate dilution of the stock solution with water and were stored 4°C. A 0.02% (w/v) of BPB, BCG, BTB and MO solutions was prepared by dissolving the accurately weighed amount of 20 mg in 100 ml of distilled water.Phthalate buffer was prepared by dissolving 2.042 g of potassium hydrogen phthalate in 50 ml of water. The pH was adjusted to 3.0 with 0.2 M HCl solution and the volume was made up to 200 ml with water.Apparatus A Shimadzu UV-160A UV-VIS spectrophotometer with 1 cm quartz cells was used. UV-Visible spectra were automatically obtained by Shimadzu UV-160A system software.Methods. General Procedure Into a series of 15 ml glass tubes 1 ml buffer solution of pH 3.0 and 1 ml ...

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High-performance liquid chromatographic method for the determination of amineptine and its main metabolite in human plasma

Cited by 11 publications

References 6 publications

Single‐dose Pharmacokinetics of Amineptine and of Its Main Metabolite in Healthy Young Adults

Single‐dose Pharmacokinetics of Amineptine and of Its Main Metabolite in Healthy Young Adults

Differential pulse, square wave and adsorptive stripping voltammetric quantification of tianeptine in tablets

A New Spectrophotometric Method for the Determination of Tianeptine in Tablets Using Ion-Pair Reagents

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