High-performance liquid chromatographic determination of 2-aminoethylphosphonic acid and 2-amino-3-phosphonopropionic acid in seawater matrix using precolumn fluorescence derivatization with o-phthalaldehyde-ethanethiol

Wang, Shu; Deng, Yao; Li, Baomin; Li, Xin; Lin, Xin; Yuan, Dongxing; Ma, Jian

doi:10.1016/j.chroma.2018.08.016

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…OPA with 2-mercaptoethanol derivatization of glufosinate. 19 A third method of derivatization for glufosinate uses 5-(dimethylamino)naphthalene-1-sulfonyl chloride (dansyl chloride) which is a pre-column derivatization method that decreases the polarity for reversed phase liquid chromatography (LC). 20 Up to 50 L of glufosinate was added to 2 mL of water and 3 mL of 10% aqueous ethylenediaminetetraacetic acid disodium salt dihydrate then shaken for 10 minutes and centrifuged at 4500 rpm.…”

Section: List Of Tablesmentioning

confidence: 99%

Trimethylation Enhancement using Diazomethane (TrEnDi) Enhances Mass Spectrometry-Based Analysis of Glufosinate and 3-(Methylphosphinico)propionic Acid in Complex Matrices

Sheedy¹

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Glufosinate is the second most commonly used herbicide worldwide; it inhibits glutamine synthetase, which results in increased ammonia levels in plants and mammals. Due to their high polarity, low volatility, small size and lack of chromophores and fluorophores, glufosinate and its breakdown product 3-(methylphosphinico) propionic acid (3-MPPA) are difficult to detect at trace levels. Using the chemical derivatization strategy trimethylation enhancement using diazomethane (TrEnDi), glufosinate and 3-MPPA react with diazomethane and tetrafluoroboric acid to become permethylated, thus reducing their polarity and forming a fixed permanent positive charge on the amine group of glufosinate.When using reversed-phase high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS), analyte retention and sensitivity are increased after derivatization, 6.7-fold for glufosinate and 6.3-fold for 3-MPPA. TrEnDi methodology was applied to canola samples from two separate fields sprayed with Liberty®. Prior to derivatization, the analysis showed no signal associated with unmodified glufosinate or 3-MPPA; however, TrEnDi modification resulted in quantifiable signals for both permethylated species.

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Section: List Of Tablesmentioning

confidence: 99%

Trimethylation Enhancement using Diazomethane (TrEnDi) Enhances Mass Spectrometry-Based Analysis of Glufosinate and 3-(Methylphosphinico)propionic Acid in Complex Matrices

Sheedy¹

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Effects of salt matrices on the determination of glyphosate, glufosinate, aminomethylphosphonic acid and 2-aminoethylphosphonic acid using reversed-phase liquid chromatography after fluorescence derivatization

Shu

Wang²,

Li³

et al. 2022

Microchemical Journal

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Chromatography and hyphenated techniques in quality-based standardization of medicinal plants: Current scenario and future perspectives

Sharma

Yadav

2023

South African Journal of Botany

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High-performance liquid chromatographic determination of 2-aminoethylphosphonic acid and 2-amino-3-phosphonopropionic acid in seawater matrix using precolumn fluorescence derivatization with o-phthalaldehyde-ethanethiol

Cited by 4 publications

References 39 publications

Trimethylation Enhancement using Diazomethane (TrEnDi) Enhances Mass Spectrometry-Based Analysis of Glufosinate and 3-(Methylphosphinico)propionic Acid in Complex Matrices

Trimethylation Enhancement using Diazomethane (TrEnDi) Enhances Mass Spectrometry-Based Analysis of Glufosinate and 3-(Methylphosphinico)propionic Acid in Complex Matrices

Effects of salt matrices on the determination of glyphosate, glufosinate, aminomethylphosphonic acid and 2-aminoethylphosphonic acid using reversed-phase liquid chromatography after fluorescence derivatization

Chromatography and hyphenated techniques in quality-based standardization of medicinal plants: Current scenario and future perspectives

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