High-performance liquid chromatographic determination of ketoprofen and naproxen in rat plasma

Lack of evidence of ketoprofen kinetic changes during the oestrous cycle in rats

“…If the mean values at the 3 different stages of the cycle are compared to data from the literature, our results agree with the findings of Foster and Jamali (1987) who reported on stereoselective pharmacokinetics of ketoprofen in the rat and found similar values of AUC (590 f 270 pg/ml) and T,,, p (1 1.2 & 1.63 h) for the active S-isomer after a 10 mg/kg ip single administration in male Sprague-Dawley rats. Also our results agree with data from Satterwhite and Boudinot (1988) after a single 25 mg/kg iv dose of ketoprofen in rats.…”

An LC–MS/MS procedure for the quantification of naproxen in human plasma: Development, validation, comparison with other methods, and application to a pharmacokinetic study

“…Until today, no liquid chromatography of naproxen has been reported with a run time of less than 5 min. More than 50% of the liquid chromatography based methods outlined in Table 3 report run times above 10 min (14 reports [21][22][23][24]27,28,31,32,35,36,38,40,44,56]). Due to UV and fluorescence detection, of which especially the former lacks additional analyte discrimination, extended run times are needed to achieve good chromatographic resolution and to avoid potential interferences from endogenous components, naproxen metabolites or co-administered drugs.…”

Impact of chronic inflammation on the pharmacokinetic–pharmacodynamic relationship of naproxen

“…Drug concentrations were analysed according to the method described by Satterwhite and Boudinot (Satterwhite and Boudinot, 1988). Briefly, plasma samples were spiked with 50 ll of internal standard (1000 mg/ml ketoprofen in methanol).…”