High-performance liquid chromatographic determination of clobazam and one of its pharmaceutical formulations

Abounassif, Mohammad A.; Kariem, Elrasheed A. Gad; Aboul‐Enein, Hassan Y.

doi:10.1016/0731-7085(87)80051-1

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1989

2020

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Today majority of marketed antiepileptic dosage forms are of clobazam e.g. Frisium, Urbanyl, etc., There are several research papers which illustrates the method for estimation of clobazam by colorimetry and HPLC in bulk and pharmaceutical dosage form [6][7]. Also, there are several bio-analytical methods developed for clobazam in biological fluids containing clobazam, like serum and plasma [8].…”

Section: Introductionmentioning

confidence: 99%

Method development and validation of clobazam in bulk and pharmaceutical dosage forms by using high performance thin layer chromatographic method

Chaithra

et al. 2020

IJAC

View full text Add to dashboard Cite

In the present research a simple, accurate, precise and cost-effective High-performance thin layer chromatographic method for the estimation of clobazam, in bulk and pharmaceutical dosage form was illustrated. The RF value of the drug was found to be 0.74 in the mobile phase, acetone: toluene: formic acid (1: 1: 0.05 v/v/v). A linear response was observed in the range of 100-700 ng with a regression coefficient of 0.999. Validation parameters were carried out as per the guidelines of International Conference for Harmonization (ICH). This method can be used in the industries for determination of clobazam to analyze the quality of formulation without interference of the excipients.

show abstract

Section: Introductionmentioning

confidence: 99%