High Performance Liquid Chromatographic Determination of Naproxen in Prepared Pharmaceutical Dosage Form and Human Plasma and its Application to Pharmacokinetic Study

Muneer, Saiqa; Muhammad, Iyad Naeem; Abrar, Muhammad

doi:10.4172/2157-7064.1000369

Cited by 13 publications

(8 citation statements)

References 14 publications

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“…The cut-off diameter for S1 is 6.5μm at 60L/min. Following each experiment, the Breezahaler® (includes capsule shells also), S1 and S2 compartments were rinsed individually with the solvent (50% ethanol), and drug particles deposited in different stages of TSI were measured using high performance liquid chromatographic method (HPLC-UV) [ 27 ]. The puerarin particle deposition from different formulations was assessed based on three parameters: the recovered dose (RD), the emitted dose (ED) and the fine particle fraction (FPF).…”

Section: Methodsmentioning

confidence: 99%

Puerarin dry powder inhaler formulations for pulmonary delivery: Development and characterization

et al. 2021

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This study aims at developing and characterizing the puerarin dry powder inhaler (DPI) formulations for pulmonary delivery. The inhalable particles size (<2 μm) was accomplished by micronization and its morphology was examined by scanning electron microscopy (SEM). The puerarin-excipient interaction in powder mixtures was analyzed by using Fourier transform infrared spectroscopy (FTIR), Raman confocal microscopy, X-Ray powder Diffraction (XRD), and differential scanning calorimetry (DSC) methods. Using a Twin stage impinger (TSI), the in-vitro aerosolization of the powder formulations was carried out at a flow rate of 60 L/min and the drug was quantified by employing a validated HPLC method. No significant interactions between the drug and the excipients were observed in the powder formulations. The fine particle fraction (FPF) of the drug alone was 4.2% which has increased five to six-fold for the formulations with aerosolization enhancers. Formulation containing lactose as large carriers produced 32.7% FPF, which further increased with the addition of dispersibility enhancers, leucine and magnesium stearate (40.8% and 41.2%, respectively). The Raman and FTIR techniques are very useful tool for understanding structural integrity and stability of the puerarin in the powder formulations. The puerarin was found to be compatible with the excipients used and the developed DPI formulation may be considered as an efficient formulation for pulmonary delivery for the management of various diseases at a very low dose.

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Section: Methodsmentioning

confidence: 99%

Puerarin dry powder inhaler formulations for pulmonary delivery: Development and characterization

et al. 2021

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“…As indicated by Figure S7 , the retention time of MPN was found to be 5.22 min. A calibration plot was established within the MPN concentration range of 0.25 µg/mL to 18 µg/mL ( Figure S7 ) [ 33 ]. The correlation between the area under the peak at 5.22 min and the concentration of the MPN followed the linear regression equation y = 1200.66 x + 2676.1 ( R 2 = 0.999) and LOQ was 0.25 µg/mL [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Gold-Deposited Nickel Foam as Recyclable Plasmonic Sensor for Therapeutic Drug Monitoring in Blood by Surface-Enhanced Raman Spectroscopy

et al. 2020

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A sensitive and recyclable plasmonic nickel foam sensor has been developed for surface-enhanced Raman spectroscopy (SERS). A simple electrochemical method was used to deposit flower-shaped gold nanostructures onto nickel foam substrate. The high packing of the gold nanoflowers onto the nickel foam led to a high enhancement factor (EF) of 1.6 × 1011. The new SERS sensor was utilized for the direct determination of the broad-spectrum β-lactam carbapenem antibiotic meropenem in human blood plasma down to one pM. The sensor was also used in High Performance Liquid Chromatography (HPLC)-SERS assembly to provide fingerprint identification of meropenem in human blood plasma. Moreover, the SERS measurements were reproducible in aqueous solution and human blood plasma (RSD = 5.5%) and (RSD = 2.86%), respectively at 200 µg/mL (n = 3), and successfully recycled using a simple method, and hence, used for the repeated determination of the drug by SERS. Therefore, the new sensor has a strong potential to be applied for the therapeutic drug monitoring of meropenem at points of care and intensive care units.

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“…A few methods for quantitative determination of Naproxen have been reported, these including HPLC (Wahbi et al,2009) (Tashtoush and Al-Taani, 2003) (Muneer et al, 2017), RP-HPLC (Pansara et al, 2013), LC-MS (Veeragoni et al, 2016), electrochemical method (Soltani et al, 2018), Ion selective electrode (Lenik et al, 2002), chemiluminescence (Yinhuan and Jiuru, 2006), Conductometric (Alhazmiand and Al Bratty, 2017), While other papers report a spectrophotometric assay of Naproxen at uv region (Nijhu et al,2011) (Maheshwari et al, 2010) (Sloka et al,2011) (Jain et al,2011). A colorimetric assay of naproxen tablets based on chemical derivatization with the chromogenic reagent 4-carboxyl-2,6-dinitrobenzene diazonium ion was developed.…”

Section: Naproxen Structurementioning

confidence: 99%

A Creative Indirect Spectrophotometric Determination of Naproxen

Mahmood¹,

Al-Sarraj²

2019

RJS

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A New, sensitive spectrophotometric method for determination of Naproxen (Nap) has been proposed. The method is based on a modification of Naproxen into a hydroxy analog (mNap). The modified compound is coupled with the diazotized p-aminobenzoic acid (PABA) in alkaline medium, the resulting orange azo dye exhibit a maximum absorption at 500 nm. Beer's law is obeyed over the concentration range from 10 to 650 µg/20 ml, (i.e. 0.5-32.5 µg/ ml) with a good sensitivity (molar absorptivity 2.14x10 4 l.mol -1 .cm -1 ), good precision (RSD% better than ±1.93%) and high accuracy (relative error % better than 0.43%), Sandell's sensitivity index is 0.0107µg.cm -2 and the limit of detection (LOD) is 0.024 µg/ml and the limit of quantitation (LOQ) is 0.082 µg/ml. The method has been applied successfully for determination of Naproxen in dosage forms after extraction of the active ingredient.

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High Performance Liquid Chromatographic Determination of Naproxen in Prepared Pharmaceutical Dosage Form and Human Plasma and its Application to Pharmacokinetic Study

Cited by 13 publications

References 14 publications

Puerarin dry powder inhaler formulations for pulmonary delivery: Development and characterization

Puerarin dry powder inhaler formulations for pulmonary delivery: Development and characterization

Gold-Deposited Nickel Foam as Recyclable Plasmonic Sensor for Therapeutic Drug Monitoring in Blood by Surface-Enhanced Raman Spectroscopy

A Creative Indirect Spectrophotometric Determination of Naproxen

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