High-performance liquid chromatographic bioanalysis of anthracycline cytostatic drugs

Quantitative liquid chromatographic analysis of anthracyclines in biological fluids

“…It has been demonstrated that heparin may directly interact with anthracyclines, interfering with their analysis, especially when starting from aqueous solutions or from plasma samples with high anthracycline concentrations. Therefore EDTA tubes are recommended [19,25,26]. Although data are scarce, no significant instability was reported in saliva and oral fluid.…”

“…Firstly, they adsorb to a variety of materials such as glass and polystyrene [3,18]. Polypropylene is recommended [19]. Secondly, anthracyclines are photolabile [20].…”

Liquid chromatography‐mass spectrometry for the quantitative bioanalysis of anticancer drugs

“…Examples of anthracycline derivatives are epirubicin, doxorubicin, daunorubicin, idarubicin, mitoxantron, and the still investigational agent nemorubicin. Several assays employing LC with fluorescence detection have been described as was reviewed in (Beijnen & Unger, 1988). These methods were very suitable for support of pharmacokinetic studies.…”

On-line simultaneous deproteinization of biological samples and trace enrichment of three dipine series using a poly(N-isopropylacrylamide-co-ethyleneglycol dimethacrylate) monolith

“…The complex matrix components such as non-volatile endogenous substances in the biological samples can interfere with the analysis of the requisite drug in the process of HPLC analysis [2,3]. Therefore, sample pretreatment is a prerequisition prior to the HPLC analysis.…”