High-Performance Liquid Chromatographic Assay of Codeine in Acetaminophen with Codeine Dosage Forms

High-Pressure Liquid Chromatographic Assays for Ticarcillin in Serum and Urine

“…The use of structural analogs of I has been proposed (5,6) as a means of obviating these two effects; in this respect particular interest has been given to the proposed use of the esters of I and its 0and N-acetylated derivatives (7)(8)(9)(10)(11)(12)(13)(14). Although I given singly or in combination is now used extensively in the treatment of a variety of tumors (2,3), its clinical value is limited due to its acute myelotoxicity and to the frequent development of irreversible cardiomyopathy [normally observed when the accumulated dose is >550 mg m-2 (4)].…”

Simultaneous Assay of Hydrocodone Bitartrate and Acetaminophen in a Tablet Formulation

“…The chromatographic difficulty associated with the simultaneous quantitation of acetaminophen and codeine has been reported (12). The problem is even more severe in this dosage form.…”

“…For instance, iodometric titration (12)(13)(14)(15) cannot be applied to penicillins having unsaturated side chains. A microtitration method ( 1 0 , l l ) has been applied to broth.…”

Poly(ethyleneglycol) column for the determination of acetaminophen, phenylephrine and chlorpheniramine in pharmaceutical formulations

“…In a chemical derivatization [7] and by GC [8]. Acet-previous work we developed and validated a HPLC aminophen and chlorpheniramine in human plasma method for the simultaneous determination of acethave been determined by LC-MS-MS and by HPLC aminophen, phenylephrine and chlorpheniramine in in combination with codeine [9] and pheudoephed-pharmaceutical formulations such as capsules and rine [10,11]. Acetaminophen, phenylpropanolamine, sachets, including the separation of impurities and chlorpheniramine and dextromethorphan were sepa-excipients with a gradient elution in a Symmerated by MECC [12,13] in cold medicines.…”