High-performance liquid chromatographic assay for melphalan in human plasma Application to pharmacokinetic studies

Generation Dependent Safety and Efficacy of Folic Acid Conjugated Dendrimer Based Anticancer Drug Formulations

“…The Melphalan concentration was determined in triplicate at different time points after appropriate dilutions by HPLC analysis (14).…”

Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis

“…Plasma levels of melphalan were determined by a HPLC method, as previously reported. 5 The method allows detection of about 20 mg/ml. Pharmacokinetic parameters were calculated with validated software, TOPFIT program, using two-compartment model.…”

Assays for the quantification of melphalan and its hydrolysis products in human plasma by liquid chromatography–tandem mass spectrometry

“…Assays for the determination of melphalan were mainly based on HPLC coupled with UV, fluorescence or electrochemical detection [7][8][9][10][11][12][13][14][15][16][17][18]. Melphalan was usually extracted from the matrix by protein precipitation.…”