High-performance liquid chromatographic analysis of basic drugs on silica columns using non-aqueous ionic eluents

Jane, I.; McKinnon, Alan E.; Flanagan, Robert J.

doi:10.1016/s0021-9673(01)90384-x

Cited by 180 publications

(19 citation statements)

References 13 publications

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“…According to the authors' knowledge, there is no written information concerning electrochemical studies on phenylephrine, but on electrochemical detection with a glassy carbon electrode in LC procedures, 11,12 or by an anodic stripping voltammetric method for the determination of PE with a modified carbon paste electrode. 13 In our work, PE gave an obvious anodic wave on a glassy carbon electrode.…”

Section: Electrochemical Reaction Of Pe On Glassy Carbon Electrodementioning

confidence: 99%

An Electrochemical Sensor for Phenylephrine Based on Molecular Imprinting

et al. 2009

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Molecularly imprinted polymers (MIPs) were applied as molecular recognition elements to an electrochemical sensor for phenylephrine. A MIPs membrane was created on a glassy carbon electrode. SEM revealed a gradual change on the morphology of modified electrodes as the ratios of function monomer and cross-linking varied. When the ratio was 4:40, the surface morphology between the imprinted electrode (M-electrode) and the control electrode (N-electrode) became unambiguously different. This artificial receptor exhibited high selectivity for the template compared to closely related analogue. The response of the sensor varied in different concentration range might due to the heterogeneity of the MIPs membrane. This sensor was also used to determine phenylephrine in tablet samples.

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Section: Electrochemical Reaction Of Pe On Glassy Carbon Electrodementioning

confidence: 99%

An Electrochemical Sensor for Phenylephrine Based on Molecular Imprinting

et al. 2009

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“…However, several other basic drugs show similar extraction, chromatographic and detection properties and could be used as the internal standard if required (cf. Jane et al 1985). On analysis of the standard disopyramide solutions by HPLC and by REMEDi the ratio of the peak heights of the analytes to the peak heights of CM 7973 or chlorpheniramine (205 nm), when plotted against analyte concentration, were linear (Y = 0.99 in each case) and passed through the origins of the graphs (Fig.…”

Section: Resultsmentioning

confidence: 96%

Disopyramide analysis using REMEDi: Comparison with EMIT and conventional high performance liquid chromatographic methods

Patel

McCarthy

Flanagan

1991

Biomedical Chromatography

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REMEDi (Rapid EMErgency Drug identification; Bio-Rad) is an automated high performance liquid chromatographic (HPLC) system designed to detect, identify and measure a range of basic and neutral drugs in 0.5-1.0 mL of urine or plasma/serum. We have evaluated REMEDi in the analysis of the antiarrhythmic drug disopyramide in patient samples. The specimens were also analysed by a conventional HPLC method, based on solvent extraction and UV detection (254 nm), and by EMIT. There were good correlations between the results obtained with each method (r = 0.91 or greater). REMEDi gave a lower mean result than EMIT [means +/- SD (mg/L): REMEDi 2.64 +/- 1.10, EMIT 3.14 +/- 1.51; t = 4.0, p less than 0.01; n = 25], but there were no other significant differences in mean results. The principal disopyramide metabolite, mono-N-desalkyldisopyramide, did not interfere in any method. Clearly REMEDi can be used for therapeutic drug monitoring of disopyramide provided enough sample is available.

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“…1 maximal response at + 1.2-1.3 V although a potential of +l.OV was chosen for routine use since this gave a reasonable signal-to-noise ratio for meptazinol, and potential interference from secondary aliphatic amines was minimized (Jane et aL, 1985). Hydrodynamic voltammograms obtained using the eluent advocated by Storey et al (1985) are also shown in Fig.…”

Section: Resultsmentioning

confidence: 99%