High-performance liquid chromatographic analysis of bioactive triterpenes in Perilla frutescens

Chen, J.H.; Zhao, Xia; Tan, Ren Xiang

doi:10.1016/s0731-7085(03)00160-2

Cited by 94 publications

(57 citation statements)

References 11 publications

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“…Among the nine compounds (1-9) identified in this study, compounds 1, 5, and 7 have previously been detected in perilla leaves. 10,20,21) Eight triterpene acids, 1, 2, and 4-9, were evaluated with respect to their anti-inflammatory activity against TPA-induced inflammation in mice, and the inhibitory effects were compared with those of two commercially available anti-inflammatory drugs, indomethacin and hydrocortisone, as shown in Table 1. All of the triterpene acids tested markedly inhibited the TPAinduced inflammation at 0.03-0.3 mg/ear of the 50% inhibitory dose, this being almost comparable with or more inhibitory than indomethacin (ID 50 value = 0.3 mg/ear).…”

Section: Resultsmentioning

confidence: 99%

Triterpene Acids from the Leaves ofPerilla frutescensand Their Anti-inflammatory and Antitumor-promoting Effects

Banno

Akihisa

Tokuda

et al. 2004

Bioscience, Biotechnology, and Biochemistry

262

161

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Section: Resultsmentioning

confidence: 99%

Triterpene Acids from the Leaves ofPerilla frutescensand Their Anti-inflammatory and Antitumor-promoting Effects

Banno

Akihisa

Tokuda

et al. 2004

Bioscience, Biotechnology, and Biochemistry

262

161

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“…151 To evaluate the quality of Perilla frutescens, a simple HPLC method was developed for the assessment of ursolic acid. 152 See supplementary material 5.3.…”

Section: 1study On the Extracting Of Ursolic Acid By Uniform Designmentioning

confidence: 99%

Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product

Sultana

2011

Journal of Enzyme Inhibition and Medicinal Chemistry

100

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Medicinal plants are becoming an important research area for novel and bioactive molecules for drug discovery. Novel therapeutic strategies and agents are urgently needed to treat different incurable diseases. Many plant derived active compounds are in human clinical trials. Currently ursolic acid is in human clinical trial for treating cancer, tumor, and skin wrinkles. This review includes the clinical use of ursolic acid in various diseases including anticancer, antitumor, and antiwrinkle chemotherapies, and the isolation and purification of this tritepernoid from various plants to update current knowledge on the rapid analysis of ursolic acid by using analytical methods. In addition, the chemical modifications of ursolic acid to make more effective and water soluble derivatives, previous and current information regarding, its natural and semisynthetic analogs, focusing on its anticancer, cytotoxic, antitumor, antioxidant, antiinflammatory, anti-HIV, acetyl cholinesterase, α-glucosidase, antimicrobial, and hepatoprotective activities, briefly discussion is attempted here for its research perspectives. This review article contains fourteen medicinally important ursolic acid derivatives and 351 references.

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“…The follow-up extractions and HPLC analysis were carried out as described above. The recovery was determined as follows (Chen et al, 2003): Recovery (%) = (A -B)/C x 100% where, A is the amount detected, B is the amount of sample without added standards, and C is the amount of the standards added. Recovery studies were performed in 5 replicates for each concentration.…”

Section: Recovery Studiesmentioning

confidence: 99%

Quantitative determination by HPLC of ent-kaurenoic and grandiflorenic acids in aerial parts of Wedelia paludosa D.C.

Batista¹,

Braga²,

Oliveira³

2005

Rev. bras. farmacogn.

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There are several reports of biological activity for kaurenoic acid (1), which is found in the aerial parts of Wedelia paludosa D.C., a herbaceous plant of the Asteraceae family abundant in Brazil, and that contains grandifl orenic acid (2) also. Both of these diterpenes were shown to cause lysis of trypomastigotes of the protozoa Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanosomiasis). This paper reports the quantitative determination of these diterpene acids in the aerial parts of W. paludosa by an isocratic RP-HPLC method employing 60% acetonitrile in water and UV detection (220 nm). Kaurenoic acid (1) was found to be more abundant (0.85 ± 0.08%) while the amount of grandifl orenic acid (2) determined was almost three times lower (0.32 ± 0.02%). No signifi cant seasonal variation was observed for these compounds in W. paludosa growing in Belo Horizonte (MG, Brazil) what points out to the aerial parts of this species are a good source of these biologically active diterpenes along all the year.

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High-performance liquid chromatographic analysis of bioactive triterpenes in Perilla frutescens

Cited by 94 publications

References 11 publications

Triterpene Acids from the Leaves ofPerilla frutescensand Their Anti-inflammatory and Antitumor-promoting Effects

Triterpene Acids from the Leaves ofPerilla frutescensand Their Anti-inflammatory and Antitumor-promoting Effects

Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product

Quantitative determination by HPLC of ent-kaurenoic and grandiflorenic acids in aerial parts of Wedelia paludosa D.C.

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