High-performance inulin and oligofructose prebiotics increase the intestinal absorption of iron in rats with iron deficiency anaemia during the growth phase

Freitas, Karine de Cássia; Amâncio, Olga Maria Silvério; Morais, Mauro Batista de

doi:10.1017/s0007114511006301

Cited by 43 publications

(49 citation statements)

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“…For confirmation of the induction of anemia, values below 11 g/dL were considered [10]. Therefore, after the induction of anemia, two groups with 12 animals each were formed; the animals were fed the following diets in the subsequent two weeks, as follows: (1) Partially hydrolyzed guar gum group (PHGG): A diet containing 75g of partially hydrolyzed guar gum (100g of Nutrisource Fiber—Nestlé ® , American Medical of Brasil Ltd., São Paulo, Brazil) and (2) control group: a diet without dietary fiber, which was replaced by 100 g of corn starch, as suggested in the literature [14].…”

Section: Methodsmentioning

confidence: 99%

“…As described in the literature, prebiotics act on the absorption of minerals by generating short-chain fatty acids forming soluble complexes, increasing the surface absorption, the number of receptors, and the intestinal beneficial bacterial populations, among other mechanisms [10,11]. …”

Section: Introductionmentioning

confidence: 99%

“…It is used on a large scale in enteral feeding, as a dietary fiber supplement, in drinks and foods, and in the food industry in general [12]. However, little is known about the effect of PHGG on the absorption of minerals and its mechanisms, but recent studies have shown the benefits associated with prebiotic intake on mineral absorption [10,12,13], with no damage to the body growth of the animals. The present study aimed to analyze the effect of PHGG intake on the food intake, body growth, intestinal weight, and ferroportin expression in the intestine and liver of anemic growing rats.…”

Section: Introductionmentioning

confidence: 99%

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Partially Hydrolyzed Guar Gum Increases Ferroportin Expression in the Colon of Anemic Growing Rats

et al. 2017

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Studies have reported a positive effect of prebiotics on the bioavailability of iron. This study evaluated the effect of partially hydrolyzed guar gum (PHGG) on iron absorption mechanisms in anemic rats. Male Wistar rats were fed 75g American Institute of Nutrition Rodent Diets for growth, pregnancy and lactation (AIN93-G) without iron for three weeks in order to induce iron deficiency anemia. Then they were fed a control diet (n = 12; without fiber) or a diet with 7.5% of PHGG (n = 12), both without iron. Food intake, body growth and the feed efficiency coefficient (FEC) were measured. The animals were euthanized after two weeks of treatment. The weight of the organs, the pH of the cecal content, and the hepatic iron and ferroportin expression in the cecum, duodenum, and liver were assessed. The intake of PHGG reduced food intake without affecting body growth, and there was a difference between the groups regarding the FEC (p = 0.026), with the highest value found in the PHGG group. The weight of the cecal content increased (p ≤ 0.001) and the pH of the cecal content was significantly lower in the PHGG group. The intake of PHGG significantly increased ferroportin expression in the cecum;however, the difference was not significant in the duodenum and the liver. PHGG seems to have a positive influence on iron absorption through transporter expression, and structural and physiological changes in the colon of anemic growing animals.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Partially Hydrolyzed Guar Gum Increases Ferroportin Expression in the Colon of Anemic Growing Rats

et al. 2017

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“…O peso dos animais foi aferido semanalmente. A partir desses dados foi calculado o ganho de peso semanal e o Coeficiente de Eficiência Alimentar (CEA), por meio da equação: CEA= ganho de peso (g) semanal/consumo alimentar (g) semanal 12 . Ao final das 12 semanas, foi realizado o Teste Oral de Tolerância à Glicose (TOTG) 13 .…”

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Ganho de peso e alterações metabólicas em camundongos submetidos à dieta hiperlipídica

et al. 2018

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“…Similarly, Yasuda et al [15] demonstrated improvement in hemoglobin repletion efficiency in young anemic pigs fed corn soybean meal supplemented with 4% dietary inulin. Recently, Freitas et al [23] showed the benefit of inulin and oligofructose prebiotics on the regeneration of haemoglobinic mass and increased intestinal Fe absorption in anaemic rats. However, to date, the comparison of the effect of prebiotics (with different fructan and arabinoxylan content) both from raw and processed wheat on Fe absorption has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

The effect of wheat prebiotics on the gut bacterial population and iron status of iron deficient broiler chickens

Tako

Glahn

Knez

et al. 2014

Nutr J

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BackgroundCurrently, there is a lot of interest in improving gut health, and consequently increasing Fe absorption, by managing the colonic microbial population. This is traditionally done by the consumption of probiotics, live microbial food supplements. However, an alternative, and often very effective approach, is the consumption of food ingredients known as prebiotics. Fructans and arabinoxylans are naturally occurring non-digestible oligosaccharides in wheat that exhibit prebiotic properties and may enhance intestinal iron (Fe) absorption. The aim of this study was to assess the effect of prebiotics from wheat on Fe bioavailability in vitro (Caco-2 cells) and in vivo (broiler chickens, Gallus gallus).MethodsIn the current study, the effect of intra-amniotic administration of wheat samples extracts at 17 d of embryonic incubation on the Fe status and possible changes in the bacterial population in intestinal content of broiler hatchlings were investigated. A group of 144 eggs were injected with the specified solution (1 ml per egg) into the amniotic fluid. Immediately after hatch (21 d) and from each treatment group, 10 chicks were euthanized and their small intestine, liver and cecum were removed for relative mRNA abundance of intestinal Fe related transporters, relative liver ferritin amounts and bacterial analysis of cecal content, respectively.ResultsThe in vivo results are in agreement with the in vitro observations, showing no differences in the hatchling Fe status between the treatment groups, as Fe bioavailability was not increased in vitro and no significant differences were measured in the intestinal expression of DMT1, Ferroportin and DcytB in vivo. However, there was significant variation in relative amounts of bifidobacteria and lactobacilli in the intestinal content between the treatments groups, with generally more bifidobacteria being produced with increased prebiotic content.ConclusionsIn this study we showed that prebiotics naturally found in wheat grains/bread products significantly increased intestinal beneficial bacterial population in Fe deficient broiler chickens. With this short-term feeding trial we were not able to show differences in the Fe-status of broilers. Nevertheless, the increase in relative amounts of bifidobacteria and lactobacilli in the presence of wheat prebiotics is an important finding as these bacterial populations may affect Fe bioavailability in long-term studies.

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High-performance inulin and oligofructose prebiotics increase the intestinal absorption of iron in rats with iron deficiency anaemia during the growth phase

Cited by 43 publications

References 52 publications

Partially Hydrolyzed Guar Gum Increases Ferroportin Expression in the Colon of Anemic Growing Rats

Partially Hydrolyzed Guar Gum Increases Ferroportin Expression in the Colon of Anemic Growing Rats

Ganho de peso e alterações metabólicas em camundongos submetidos à dieta hiperlipídica

The effect of wheat prebiotics on the gut bacterial population and iron status of iron deficient broiler chickens

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