The authors report high temperature continuous-wave ͑cw͒ operations of broad-gain quantum cascade lasers based on the anticrossed dual-upper-state to multiple-lower-state design. The devices exhibit extremely wide electroluminescence ͑Ͼ600 cm −1 ͒ and subthreshold amplified spontaneous emission ͑ϳ570 cm −1 ͒ spectra at room temperature. Despite showing such broad electroluminescence spectra, the high-reflection coated, buried heterostructure lasers operating at 6.8 m demonstrate a low threshold current density of ϳ1.5 kA/ cm 2 and a high power of Ͼ500 mW with a high slope efficiency of ϳ1.6 W / A in cw mode at 300 K. The maximum cw operating temperature of above 100°C is achieved.Quantum cascade ͑QC͒ lasers 1 are promising light sources for many chemical sensing applications in the midinfrared spectral range. For industrial application, broadband wavelength tuning of external-cavity QC lasers with very broad gain-width ͑⌬ / 0 Ͼ 0.3͒ has been demonstrated. 2,3 For instance, a five wavelength stack laser 2 demonstrates a wide wavelength tuning of 432 cm −1 and another two wavelength stack laser 3 also did a tuning range of 292 cm −1 both at room temperature. The latter laser was achieved cw operation above room temperature by using the combination of junction down mounting with diamond heat-sink and buried hetero structure.However, for multiple-stack approach, it may raise problems such as inhomogeneous spectral behavior owing to spatial heterogeneity of active region 4 in which it takes a longer time ͑Ͼ1 ps͒ for electron transfer between spatially separated wavelength stacks. The following fact was clarified on longitudinal mode-stability in bipolar lasers. When the intraband relaxation time is longer than 3 ϫ 10 −13 s, the gain shows strong nonuniformity across the spectral or energy distributions and at the same time the gain of some resonating modes is increased; 5 this hinders the single mode operation under wavelength tuning. Although the short relaxation lifetime 1 ϫ 10 −13 s in cases of bipolar lasers is reported, 6 even shorter relaxation times would be required for modestability in QC lasers due to very high stimulated emission rates. 7 On this issue, in an identical-stack ͑homogeneous cascade͒ QC laser, depression of electron population in a upper subband, induced by stimulated emissions can be compensated quickly by relaxation from other subbands in the same space, in an anticrossed dual-upper-state ͑DAU͒ design 8 because of sufficient spatial overlapping of wave functions of both subbands. Thus, gain spectrum of an identical-stack DAU QC laser would be viewed as spectrally homogeneous one. Obviously, an inherently broad and spectrally homogeneous gain profile of the laser medium with translational symmetry is preferable for single mode operation in the external cavity application of QCLs. Recently we have reported broad-gain ͑⌬ / 0 ϳ 0.4, ϳ500 cm −1 full width at half maximum, FWHM͒ and temperature insensitive ͑T 0 ϳ 510 K͒ operations of QC lasers based on the active region with translational symmetry....