High Performance Fine-Grained Biodegradable Mg-Zn-Ca Alloys Processed by Severe Plastic Deformation

Vinogradov, Alexei; Васильев, Е. В.; Копылов, В. И.; Linderov, Mikhail; Brilevesky, Alexander; Мерсон, Д. Л.

doi:10.3390/met9020186

Cited by 44 publications

(34 citation statements)

References 91 publications

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“…Подробно режимы обработки и получающиеся микроструктуры будут описаны в специально посвященной публикации. Краткую информацию об использованных технологиях можно найти в указанных статьях [14][15][16][17].…”

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Investigation of the cytotoxic effects of magnesium alloys on cell cultures

Фролова

Boykov

Таркова

et al. 2019

PKiK

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Background. Metallic stent implantation is associated with an increased risk of adverse events, such as prolonged endothelial dysfunction, constant traumatisation of the vessel wall, chronic local inflammation and thrombosis. Thus, the development and manufacturing of bioresorbable stents, which maintain the required support during the vessel healing period and completely dissolve without any side effects, is highly relevant. At present, magnesium alloys are regarded the most applicable for this purpose due to their low corrosion resistance and high biocompatibility. Aim. To assess the cytotoxicity of different magnesium alloys in vitro. Methods. Using strain tempering, seven samples with different yield stress levels were produced: sample 1, MgZnZr (ZK60) 310 МPа; sample 2, MgZnCa (ZX10) 60 МPа; sample 3, MgZnCa (ZX40) 130 МPа; sample 4, MgYZn (WZ31) 300 МPа; sample 5, MgYZn (WZ31) 275 МPа; sample 6, MgYZn (WZ20) 340 МPа and sample 7, MgZnZr (ZK60) 180 МPа. The samples were incubated in a culture medium to obtain the extract, which was further tested on immortalised human fibroblasts. The cytotoxicity of the obtained extract was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, optical microscopy and pH test. Results. In MTT assay, sample 7 was significantly cytotoxic (mean cell survival: 48% [2% ± 1%]), whereas sample 5 was slightly cytotoxic (mean cell survival: 81% [4% ± 14%]). In optical microscopy, the same samples showed the lowest cell density. In flow cytometry, the number of necrotic cells significantly increased in sample 7 (8.25%) and only slightly increased in samples 1 and 5 (3.449% and 3.626%, respectively). Furthermore, samples 5 and 7 showed the highest medium pH. Conclusion. The composition and strain tempering method magnesium alloys are directly correlated with the degree of cell necrosis, change in morphology and medium pH in vitro.Received 7 June 2019. Revised 28 October 2019. Accepted 6 November 2019.Funding: The work is supported by the Ministry of Science of Russian Federation (project RFMEFI58317X0070).Conflict of interest: Authors declare no conflict of interest.

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Section: методыunclassified

Investigation of the cytotoxic effects of magnesium alloys on cell cultures

Фролова

Boykov

Таркова

et al. 2019

PKiK

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“…Besides the chemical composition, the biomedical properties profile of Mg alloys can be manipulated by tailoring the microstructure by various thermomechanical treatments, of which severe plastic deformation (SPD) is one of the recently emerged tools [29]. What can be stated safely at this stage is that enhancement of mechanical performance (particularly, the ductility and fatigue properties [30,31]) can be achieved with Mg alloys by SPD processes without a loss in their resistance to biocorrosion [32][33][34][35]. Among the procedures devised for deformation processing of wrought Mg alloys, conventional rolling and direct extrusion are the most popular, though they tend to produce the alloys with a strong texture and, therefore, a strongly asymmetrical mechanical response.…”

Section: Introductionmentioning

confidence: 99%

“…Different techniques render different results for different needs and should be used accordingly. For example, the alloys with the LPSO structure benefit strongly from the fibre-like composite structure produced by direct extrusion, whereas many alloys like ZK60, AZ31, Mg-Zn-Ca, etc., exhibit outstanding properties profiles after a combination of various deformation processes such as equal channel angular pressing (ECAP) and extrusion [40,41], or ECAP/extrusion and swaging [31,42], multiaxial forging and rolling [43], etc., [44]. In addition to tremendous hardening, the microstructure refinement often exerts a beneficial effect on the corrosion resistance of many structural materials [45], including Mg alloys [46][47][48].…”

Section: Introductionmentioning

confidence: 99%

The Functional Properties of Mg–Zn–X Biodegradable Magnesium Alloys

et al. 2020

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The implantation of metallic devices in orthopaedic surgical procedures and coronary angioplasty is associated with the risk of various adverse events: (i) mechanical (premature failure), (ii) chemo-mechanical (corrosion and corrosion-fatigue degradation) and (iii) biomedical (chronic local inflammatory reactions, tissue necrosis, etc.). In this regard, the development of biodegradable implants/stents, which provide the necessary mechanical support for the healing period of the bone or the vessel wall and then are completely resorbed, has bright prospects. Magnesium alloys are the most suitable candidates for that purpose due to their superior mechanical performance, bioresorbability and biocompatibility. This article presents the results of the comparative research on several wrought biodegradable alloys, assessing their potential for biomedical applications. The Mg–Zn–X alloys with different chemical compositions and microstructures were produced using severe plastic deformation techniques. Functional properties pivotal for biomedical applications—mechanical strength, in vitro corrosion resistance and cytotoxic activity—were included in the focus of the study. Excellent mechanical performance and low cytotoxic effects are documented for all alloys with a notable exception for one of two Mg–Zn–Zr alloys. The in vitro corrosion resistance is, however, below expectations due to critical impurities, and this property has yet to be drastically improved through the cleaner materials fabrication processing before they can be considered for biomedical applications.

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“…In general, in wrought Mg alloys, beside a hexagonal close packed (hcp) lattice, deformation texture and the formation of precipitates contributes to the tension-compression yield asymmetry with higher strength values in tension than that in compression [4]. The grain refinement and/or texture weakening achieved by, for example, severe plastic deformation techniques or the twin-roll casting process also can lead to a lower yield asymmetry in Mg-Zn-Ca alloys [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Grain Size-Related Strengthening and Softening of a Precompressed and Heat-Treated Mg–Zn–Ca Alloy

et al. 2020

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The impact of precompression, thermal treatment and its combination on the deformation behaviour of an extruded Mg–Zn–Ca (ZX10) alloy was studied with respect to a varied average grain size. The Hall–Petch plot was used to highlight the impact in a wide grain size interval. The initial texture of the wrought alloy was characterized by X-ray diffraction. Moreover, the evolution of microstructure and texture was provided by the electron backscatter diffraction (EBSD) technique. The obtained results indicate the strong contribution of deformation-thermal treatment on the resulting deformation behaviour. Particularly, after precompression and heat treatment, higher strengthening effect was observed in the reversed tensile loaded compared to compressed samples without any change in the Hall–Petch slope throughout the grain size interval. Unlike this strengthening effect, a reversed tension–compression yield asymmetry with higher strength values in compression has been obtained.

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High Performance Fine-Grained Biodegradable Mg-Zn-Ca Alloys Processed by Severe Plastic Deformation

Cited by 44 publications

References 91 publications

Investigation of the cytotoxic effects of magnesium alloys on cell cultures

Investigation of the cytotoxic effects of magnesium alloys on cell cultures

The Functional Properties of Mg–Zn–X Biodegradable Magnesium Alloys

Grain Size-Related Strengthening and Softening of a Precompressed and Heat-Treated Mg–Zn–Ca Alloy

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