High-performance counter-current chromatography separation of extract from Peucedanum cervaria towards the isolation of coumarin derivatives

Skalicka‐Woźniak, Krystyna; Mroczek, Tomasz; Głowniak, Kazimierz

doi:10.1055/s-0033-1352191

Cited by 6 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different ratios of heptane, ethyl acetate, methanol, and water (HEMW) ( Table 1), being the most suitable for the separation of coumarins, were tested (Skalicka-Woź niak, Mroczek, & Kozioł, 2015). The composition of the two-phase solvent system was selected according to the partition coefficient (K) and peak resolution of the target compounds.…”

Section: Hpccc Separation Proceduresmentioning

confidence: 99%

Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography

et al. 2015

View full text Add to dashboard Cite

Section: Hpccc Separation Proceduresmentioning

confidence: 99%

Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography

et al. 2015

View full text Add to dashboard Cite

“…The development of suitable instrumentation for the separation analysis of organic compounds has been extensively applied to the detection, isolation, and structural elucidation of secondary metabolites. Notably, HPLC in conjunction with NMR and MS has the potential for the full structural elucidation of new substances without the need for conventional isolation . Nevertheless, the determination of the AC of such compounds can be a complex task due to the limited availability of chromatographic chiroptical techniques.…”

Section: Introductionmentioning

confidence: 99%

Enantiomeric high-performance liquid chromatography resolution and absolute configuration of 6β-benzoyloxy-3α-tropanol

2016

View full text Add to dashboard Cite

The absolute configuration of the naturally occurring isomers of 6β-benzoyloxy-3α-tropanol (1) has been established by the combined use of chiral high-performance liquid chromatography with electronic circular dichroism detection and optical rotation detection. For this purpose (±)-1, prepared in two steps from racemic 6-hydroxytropinone (4), was subjected to chiral high-performance liquid chromatography with electronic circular dichroism and optical rotation detection allowing the online measurement of both chiroptical properties for each enantiomer, which in turn were compared with the corresponding values obtained from density functional theory calculations. In an independent approach, preparative high-performance liquid chromatography separation using an automatic fraction collector, yielded an enantiopure sample of OR (+)-1 whose vibrational circular dichroism spectrum allowed its absolute configuration assignment when the bands in the 1100-950 cm(-1) region were compared with those of the enantiomers of esters derived from 3α,6β-tropanediol. In addition, an enantiomerically enriched sample of 4, instead of OR (±)-4, was used for the same transformation sequence, whose high-performance liquid chromatography follow-up allowed their spectroscopic correlation. All evidences lead to the OR (+)-(1S,3R,5S,6R) and OR (-)-(1R,3S,5R,6S) absolute configurations, from where it follows that samples of 1 isolated from Knightia strobilina and Erythroxylum zambesiacum have the OR (+)-(1S,3R,5S,6R) absolute configuration, while the sample obtained from E. rotundifolium has the OR (-)-(1R,3S,5R,6S) absolute configuration.

show abstract

“…In a study on the botanical origins of the Hakkari propolis samples, Bayram (2015) [38] reported that 71 plant taxa belonging to 34 families were determined to be present at different ratios in the propolis samples and the pollens of the plants belonging to the families of Apiaceae (2.7%-35%), Asteraceae (3.4%-35.4%) and Fabaceae (12%-66%). It has been reported that coumarins angelicin [39,40], bergapten [39,41,42], bergaptol [43,44], columbianetin [43], decursin [45], jatamansin [46], lomatin [47,48] methoxsalen [49], oroselone [50], osthole [51], oxypeucedanin [52,53,54], prangenin [55], psoralen [40,43], seselin [56], suberosin [57,58], xanthotoxol [59,60], 2-isopropenyl-2,3-dihydrofuro[3,2-g]chromen-7-one [61], 3-methyl-but-2-enoic acid, 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]chromen-3-yl ester [62], and 4-(3-methyl-2-oxobutoxy)-7H-furo[3,2-g][1]benzopyran-7-one (isooxypeucedanin) [63] are found in the chemical composition of different plants belonging to the Apiaceae family. Similarly, psoralen, angelicin [64], bergapten [65], and seselin [66] have been reported to be present in the Fabaceae family plants.…”

Section: Resultsmentioning

confidence: 99%

Chemical Characterization of 64 Propolis Samples from Hakkari, Turkey

Bayram¹,

Sorkun²,

Öz³

et al. 2018

Rec.Nat.Prod.

View full text Add to dashboard Cite

Propolis is a resinous substance produced by honey bees from various plants they visit. Sixty-four propolis samples were collected from different localities of four districts (Merkez, Yüksekova, Şemdinli, and Çukurca) in Hakkari territory. Ethanol extracts of the propolis samples were prepared, and their chemical contents were determined by gas chromatography-mass spectroscopy (GC-MS). Flavonoids were generally found in a high concentration in Şemdinli samples of Turkey. Twenty-seven coumarins were identified in the 28 propolis samples among studied 64 ones. Except suberosin, the coumarins were never reported before in any propolis sample with Turkish origin. The propolis samples belonging to Yüksekova were found to be richer in coumarins than the others, and the most richest one among the Yüksekova apiaries, was found to be Akocak sample (Y2) with 41.99% total yield, followed by Akçalı sample (Y5) (30.86%). This is a first comprehensive and original report about the chemical profile of propolis samples from Hakkari. The propolis samples from Hakkari exhibited a chemical content rich in flavonoids including coumarins and furocoumarins.

show abstract

High-performance counter-current chromatography separation of extract from Peucedanum cervaria towards the isolation of coumarin derivatives

Cited by 6 publications

References 0 publications

Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography

Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography

Enantiomeric high-performance liquid chromatography resolution and absolute configuration of 6β-benzoyloxy-3α-tropanol

Chemical Characterization of 64 Propolis Samples from Hakkari, Turkey

Contact Info

Product

Resources

About