The problems arising due to massive data storage and data analysis can be handled by recent technologies, like cloud computing and parallel computing. MapReduce, MPI, CUDA, OpenMP, OpenCL are some of the widely available tools and techniques that use multithreading approach. However, it is a challenging task to use these technologies effectively to handle the compute intensive problems in the fields like life science, environment, fluid dynamics, image processing, etc. In this paper, we have used many core platforms with graphics processing units (GPU) to implement one of very important and fundamental problem of sequence alignment in the field of bioinformatics. Dynamic and concurrent kernel features offered by graphics card are used to speed up the performance. With these features, we achieved a speed up of around 120X and 55X. We have coupled well-known tiling technique with these features and observed a performance improvement up to 4X and 2X, as compared to non-tiling execution. The paper also analyses resource parameters, GPU occupancy and proposes their relationship with the design parameters for the chosen algorithm. These observations have been quantified and the relationship between the parameters is presented. The results of study can be extended further to study similar algorithms in this area. 285 | P a g e www.ijacsa.thesai.org Algorithms that are based on dynamic programming methodology giving accurate results but taking exponential time to produce the output. For example, Needleman and Wunsch [NW] [1], Smith and Waterman [SW], [2] proposed the algorithm for global and sequence alignment, respectively.