High-performance acetone gas sensor based on Pt–Zn2SnO4 hollow octahedra for diabetic diagnosis

Hạnh, Nguyễn Hồng; Duy, Lai Van; Hung, Chu Manh; Xuan, C.T.A.; Duy, Nguyễn Văn; Hòa, Nguyễn Đức

doi:10.1016/j.jallcom.2021.161284

Cited by 59 publications

(22 citation statements)

References 91 publications

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“…The response to one ppm, two ppm, and five ppm acetone was 3.81, 4.82, and 6.64 folds, respectively, and thus, a clear resolution existed between lower concentrations of acetone. Hanh et al utilized the synergetic effect of the hollow structure of Zn 2 SO 4 (ZTO) and the high catalytic activity of the Pt catalyst to develop a highly sensitive and stable acetone sensor with a limit of detection at the ppb level [ 93 ]. The Pt10-ZTO sensor, that is, the sensor with a Pt loading amount of 1 wt%, performed best amongst the sensors with different compositions.…”

Section: Sensing Methodologies For Breath Analysismentioning

confidence: 99%

Exhaled Breath Analysis for Diabetes Diagnosis and Monitoring: Relevance, Challenges and Possibilities

et al. 2021

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With the global population prevalence of diabetes surpassing 463 million cases in 2019 and diabetes leading to millions of deaths each year, there is a critical need for feasible, rapid, and non-invasive methodologies for continuous blood glucose monitoring in contrast to the current procedures that are either invasive, complicated, or expensive. Breath analysis is a viable methodology for non-invasive diabetes management owing to its potential for multiple disease diagnoses, the nominal requirement of sample processing, and immense sample accessibility; however, the development of functional commercial sensors is challenging due to the low concentration of volatile organic compounds (VOCs) present in exhaled breath and the confounding factors influencing the exhaled breath profile. Given the complexity of the topic and the skyrocketing spread of diabetes, a multifarious review of exhaled breath analysis for diabetes monitoring is essential to track the technological progress in the field and comprehend the obstacles in developing a breath analysis-based diabetes management system. In this review, we consolidate the relevance of exhaled breath analysis through a critical assessment of current technologies and recent advancements in sensing methods to address the shortcomings associated with blood glucose monitoring. We provide a detailed assessment of the intricacies involved in the development of non-invasive diabetes monitoring devices. In addition, we spotlight the need to consider breath biomarker clusters as opposed to standalone biomarkers for the clinical applicability of exhaled breath monitoring. We present potential VOC clusters suitable for diabetes management and highlight the recent buildout of breath sensing methodologies, focusing on novel sensing materials and transduction mechanisms. Finally, we portray a multifaceted comparison of exhaled breath analysis for diabetes monitoring and highlight remaining challenges on the path to realizing breath analysis as a non-invasive healthcare approach.

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Section: Sensing Methodologies For Breath Analysismentioning

confidence: 99%

Exhaled Breath Analysis for Diabetes Diagnosis and Monitoring: Relevance, Challenges and Possibilities

et al. 2021

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“…Although MOx micro/nanostructures such as SnO 2 , ZnO, and TiO 2 have been used as gas-sensing materials for several decades due to their unique physicochemical properties, the lack of selectivity and high operating temperatures (200–600 °C) of these oxides [ 45 ] has led to the development of special MOx sensors. Improvements include doping/decoration with noble metals (for example, Pd, Ag, Pt, and Au) [ 83 , 84 ], surface functionalization [ 85 , 86 ], composite production (for example, MOx–MOx, polymer–MOx, and MOx–carbon nanotubes, among other compositions) [ 87 ].…”

Section: Description Of Gas Sensorsmentioning

confidence: 99%

“…The lowest measurements for acetone, ethanol, and toluene vapors in humid environments (10–30% relative humidity) were performed at 1 ppm. Hanh et al [ 45 ] developed an acetone gas sensor using Pt–Zn 2 SnO 4 hollow octahedra for exhaled breath analysis to diagnose diabetes. Zn 2 SnO 4 hollow octahedra prepared by a hydrothermal method were decorated with different amounts of Pt nanoparticles through a simple mixing process to optimize the Pt content to enhance the acetone-sensing performance.…”

Section: Description Of Gas Sensorsmentioning

confidence: 99%

Metal Oxide Gas Sensors to Study Acetone Detection Considering Their Potential in the Diagnosis of Diabetes: A Review

2023

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Metal oxide (MOx) gas sensors have attracted considerable attention from both scientific and practical standpoints. Due to their promising characteristics for detecting toxic gases and volatile organic compounds (VOCs) compared with conventional techniques, these devices are expected to play a key role in home and public security, environmental monitoring, chemical quality control, and medicine in the near future. VOCs (e.g., acetone) are blood-borne and found in exhaled human breath as a result of certain diseases or metabolic disorders. Their measurement is considered a promising tool for noninvasive medical diagnosis, for example in diabetic patients. The conventional method for the detection of acetone vapors as a potential biomarker is based on spectrometry. However, the development of MOx-type sensors has made them increasingly attractive from a medical point of view. The objectives of this review are to assess the state of the art of the main MOx-type sensors in the detection of acetone vapors to propose future perspectives and directions that should be carried out to implement this type of sensor in the field of medicine.

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“…Highly porous thin-wall SnO 2 fibers of hierarchical structure composed of Pt NPs-decorated SnO 2 NTs, have been investigated for acetone and toluene detection as diabetes and LC biomarkers respectively; increased sensor responses for both analytes were permitted, due to MNPs-functionalization [ 58 ]. More recently, Pt-decorated Zn 2 SnO 4 hollow octahedra were used for enhanced selective detection of acetone, in ppb levels, adequate for breath analysis applications and diabetes diagnosis [ 79 ]. In another application, Au NPs-decorated SWCNTs were used for selective detection of H 2 S (halitosis biomarker) in the presence of NH 3 and NO, with a LOD of 3 ppb [ 80 ].…”

Section: Types Of Nanomaterial-based Sensors In Breath Analysismentioning

confidence: 99%

Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors

Kaloumenou

Skotadis

Lаgopati

et al. 2022

Sensors

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Early-stage disease diagnosis is of particular importance for effective patient identification as well as their treatment. Lack of patient compliance for the existing diagnostic methods, however, limits prompt diagnosis, rendering the development of non-invasive diagnostic tools mandatory. One of the most promising non-invasive diagnostic methods that has also attracted great research interest during the last years is breath analysis; the method detects gas-analytes such as exhaled volatile organic compounds (VOCs) and inorganic gases that are considered to be important biomarkers for various disease-types. The diagnostic ability of gas-pattern detection using analytical techniques and especially sensors has been widely discussed in the literature; however, the incorporation of novel nanomaterials in sensor-development has also proved to enhance sensor performance, for both selective and cross-reactive applications. The aim of the first part of this review is to provide an up-to-date overview of the main categories of sensors studied for disease diagnosis applications via the detection of exhaled gas-analytes and to highlight the role of nanomaterials. The second and most novel part of this review concentrates on the remarkable applicability of breath analysis in differential diagnosis, phenotyping, and the staging of several disease-types, which are currently amongst the most pressing challenges in the field.

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High-performance acetone gas sensor based on Pt–Zn2SnO4 hollow octahedra for diabetic diagnosis

Cited by 59 publications

References 91 publications

Exhaled Breath Analysis for Diabetes Diagnosis and Monitoring: Relevance, Challenges and Possibilities

Exhaled Breath Analysis for Diabetes Diagnosis and Monitoring: Relevance, Challenges and Possibilities

Metal Oxide Gas Sensors to Study Acetone Detection Considering Their Potential in the Diagnosis of Diabetes: A Review

Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors

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