High- or low-salt diet from weaning to adulthood: Effect on body weight, food intake and energy balance in rats

Reduced rat plasma lysophosphatidylglycerol or lysophosphatidic acid level as a biomarker of aristolochic acid-induced renal and adipose dysfunctions

“…LS feeding, however, significantly lower the body weight in AA-untreated rats compared to those of corresponding rats fed NS and HS. In contrast to our results, Coelho et al showed that feeding a low salt chow induced higher body weight gains in rats compared to those fed normal or high salt chows despite low energy expenditure [12]. The extreme restriction of dietary salt intake in our study may cause reduced body weight, but its mechanism remains unclear.…”

“…However, prolonged intake of a low-salt chow from weaning to adulthood increased the body weight of rats despite their lower food intake compared to rats fed a normal or high-salt chow [12]. In this study, we examined whether AA treatment and differences of dietary salt consumption affect plasma levels of LPLs including LPA as a possible …”

Safety evaluation of main alkaloids from Rhizoma Coptidis

“…Because the ALT and AST in females had a more significant increase than that in males in the RC group as compared with the controls. But body weight change is related to gender, diet patterns, daily exercise, the types of species and energy balance (Gray et al, 1995;Cortright et al, 1997;Baptista et al, 2002;Coelho et al, 2006;Geer and Shen, 2009). Specially designed experiments are further needed for providing a definite answer to this question.…”

Avaliação do sistema renina - angiotensina tecidual e circulante em prole de ratas que receberam sobrecarga ou restrição de sal na dieta durante a gestação e amamentação

“…Talvez isto não tenha acontecido pelo fato de que a infusão de angiotensina II exógena não simula aquilo que ocorre quando há um estímulo fisiológico tal como a restrição crônica de sal na dieta. Tal possibilidade encontra suporte em um estudo anterior do nosso laboratório [27]. Neste estudo foi observado que na vigência de dieta hipossódica, não há aumento generalizado de angiotensina II circulante e tecidual em ratos machos.…”

“…Em ratos alimentados com dieta hipossódica verificou-se desenvolvimento de obesidade [27] e o oposto em animais que foram infundidos com angiotensina II [28].…”