High oncogenic risk human papillomavirus and urinary bladder cancer

Лоран, О Б; Sinyakova, L. A.; Гундорова, Л. В.; Kosov, V A; Косова, И В; Pogodina, I.E. Pogodina; Колбасов, Д Н

doi:10.18565/urol.2017.3.60-66

Cited by 3 publications

(3 citation statements)

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“…Other malignancies associated with HPV include SCC of the skin/nose tip and skin appendages [58][59][60][61][62]. Association between HPV and bladder cancer even though without uniform conclusions has also been reported in several studies [63][64][65][66][67][68][69].…”

Section: Hpv-associated Diseases In Menmentioning

confidence: 94%

Human Papillomavirus (HPV) Infection in Males: A Need for More Awareness

Manga¹,

Fowotade²,

Yahaya³

2019

Current Perspectives in Human Papillomavirus

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Globally, human papillomavirus (HPV) is the most common viral sexually transmitted pathogen, which is significantly associated with high morbidity and mortality in both sexes. Except those vaccinated, virtually all sexually active individuals will be infected with HPV in their lifetime. Although most HPV infections are transient, association with anogenital warts, cervical, penile, and other malignancies have been reported. HPV can be transmitted from one person to another through contact especially during sexual contact including anal, vaginal, or oral. Although HPV infection affects both males and females, its causal association with cervical cancer has made most literature to be mainly on females. In view of its sexual transmissibility and the increasing prevalence of HPV-related malignancies among males worldwide, there is need for more awareness on the infection in males. Most developed countries offer HPV vaccination for girls, but vaccine recommendations for boys are still relatively uncommon especially in developing countries where the burden of HPVrelated malignancies is still very high. The current discourse highlights the need for increased awareness on HPV vaccination among this neglected gender group.

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Section: Hpv-associated Diseases In Menmentioning

confidence: 94%

Human Papillomavirus (HPV) Infection in Males: A Need for More Awareness

Manga¹,

Fowotade²,

Yahaya³

2019

Current Perspectives in Human Papillomavirus

View full text Add to dashboard Cite

show abstract

“…In a cross‐sectional study assessing biopsy specimens of 16 patients with BC, HSV gene sequences were identified in 9% of all tissue specimens, guiding the stage for subsequent exploration of the relationship between HSV and BC 97 . Notably, HSV‐1 and HSV‐2 are broadly recognized to induce chronic and latent infections in the genitourinary tract, leading to cellular atrophy as well as pathological changes in the intranuclear inclusion bodies 98 . In addition, HPV has been found to potentially trigger HSV infection 99 ; moreover, both HSV and HPV have been detected in BC samples using polymerase chain reaction (PCR) in a study of BC 65,100 .…”

Section: Hsv and Bcmentioning

confidence: 99%

“…97 Notably, HSV-1 and HSV-2 are broadly recognized to induce chronic and latent infections in the genitourinary tract, leading to cellular atrophy as well as pathological changes in the intranuclear inclusion bodies. 98 In addition, HPV has been found to potentially trigger HSV infection 99 ; moreover, both HSV and HPV have been detected in BC samples using polymerase chain reaction (PCR) in a study of BC. 65,100 Therefore, the potential contribution of HSV infection in the development of BC cannot be ignored.…”

Section: Virusmentioning

confidence: 99%

Role of human papillomavirus and associated viruses in bladder cancer: An updated review

Yao,

Xu,

Duan

et al. 2023

Journal of Medical Virology

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Bladder cancer (BC) is a complex disease affecting the urinary system and is regulated by several carcinogenic factors. Viral infection is one such factor that has attracted extensive attention in BC. Human papillomavirus (HPV) is the most common sexually transmitted infection, and although multiple researchers have explored the role of HPV in BC, a consensus has not yet been reached. In addition, HPV‐associated viruses (e.g., human immunodeficiency virus, herpes simplex virus, BK virus, and JC virus) appear to be responsible for the occurrence and progression of BC. This study systematically reviews the relationship between HPV‐associated viruses and BC to elucidate the role of these viruses in the onset and progression of BC. In addition, the study aims to provide a greater insight into the biology of HPV‐associated viruses, and assess potential strategies for treating virus‐induced BC. The study additionally focuses on the rapid development of oncolytic viruses that provide a potentially novel option for the treatment of BC.

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Genetic and epigenetic characteristics of non-muscle invasive and muscle invasive bladder cancer in patients infected by human papillomavirus: literature review

et al. 2023

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Infectious diseases and chronic inflammation are important risk factors for the development of malignant tumors in humans. One of the key infectious agents involved in human oncogenesis is the human papillomavirus (HPV). Non-muscle invasive bladder cancer is defined as a superficial neoplasia limited to the mucosa, aggravated by recurrence in 80 % of cases and progression in 30 % of cases. The development of this disease is associated with the influence of various carcinogenic agents, including HPV. Currently, a direct relationship has been revealed between the presence of viral DNA in the tumor tissue of the bladder and markers of proliferative activity, angiogenesis, and apoptosis factors. More and more researchers believe in the involvement of the virus in the development of recurrent forms of bladder cancer and the emergence of its invasive/poorly differentiated forms. Improving the diagnosis and postoperative monitoring of non-muscle invasive and muscle invasive bladder cancer is not possible without the improvement of minimally invasive molecular methods, which requires an understanding of the molecular mechanisms of HPV-associated carcinogenesis.Therefore, this review focuses on the analysis of the molecular mechanisms of HPV effect on progression of non-muscle invasive and muscle invasive bladder cancer. The features of miRNA expression in patients with papillomavirus infection of high oncogenic risk types and non-muscle invasive or muscle invasive bladder cancer are considered in detail. In particular, the role of miR-34а, -218, -20a, -424, -200a, -205-5p, -944, -100, -99a, -202, -30a, -145-5p, -195 and -199a-5 is described in the development and progression of bladder cancer. The mechanisms of disruption in the functioning of key cell signaling pathways during HPV integration in patients with bladder cancer, including changes in gene copy number and methylation level, are also considered.However, the number of HPV-positive tumor specimens that have been comprehensively analyzed using genome-wide studies in the literature remains small. Larger patient cohorts would be useful to further refine HPV-associated integration events and genomic changes, as well as to study clinical manifestations of the consequences of these alterations. Further research on the clinical implications of the observed genomic changes is needed to accurately stratify patients for targeted therapy, radiation and chemotherapy.

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High oncogenic risk human papillomavirus and urinary bladder cancer

Cited by 3 publications

References 0 publications

Human Papillomavirus (HPV) Infection in Males: A Need for More Awareness

Human Papillomavirus (HPV) Infection in Males: A Need for More Awareness

Role of human papillomavirus and associated viruses in bladder cancer: An updated review

Genetic and epigenetic characteristics of non-muscle invasive and muscle invasive bladder cancer in patients infected by human papillomavirus: literature review

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