High Numbers of Interferon-.GAMMA.-Producing T Cells and Low Titers of Anti-Tuberculous Glycolipid Antibody in Individuals with Latent Tuberculosis

Guio, Heinner; Ashino, Yugo; Saitoh, Hiroki; Siddiqi, Umme Ruman; Mizusawa, Masako; Xiao, Peng; Soto, Alonso; Theo, Andros; Hattori, Toshio

doi:10.1620/tjem.220.21

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Moreover, by using ROC analysis, we found that anti-TDM-M and anti-TBGL IgG had similar area under the curve (AUC), but AUC of anti-TBGL IgG improved when MAC positive subjects were excluded. We also noticed that the average anti-TBGL titers and the proposed cut-off levels appear to vary according to severity of the disease and the origin of the studied subjects [6,7,[28][29][30][31].…”

Section: Accepted Manuscriptmentioning

confidence: 85%

Diagnostic value of antibody responses to multiple antigens from Mycobacterium tuberculosis in active and latent tuberculosis

Senoputra

Shiratori

Hasibuan

et al. 2015

Diagnostic Microbiology and Infectious Disease

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Section: Accepted Manuscriptmentioning

confidence: 85%

Diagnostic value of antibody responses to multiple antigens from Mycobacterium tuberculosis in active and latent tuberculosis

Senoputra

Shiratori

Hasibuan

et al. 2015

Diagnostic Microbiology and Infectious Disease

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“…The assay was performed as described previously (Guio et al 2010). Freshly isolated peripheral blood mononuclear cells (2.5 × 10 5 per well) were cultured on plates precoated with antibody against IFN-γ (IGRA ELISPOT.…”

Section: Igra Elispot Assaymentioning

confidence: 99%

Distinct Clinical Features in Nontuberculous Mycobacterial Disease with or without Latent Tuberculosis Infection

Siddiqi

Chagan-Yasutan

Nakajima

et al. 2012

Tohoku J. Exp. Med.

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Nontuberculous mycobacteria (NTM) diseases are in the face of a progressive increase even in immune-competent subjects, and the clinical features of NTM diseases are heterogenous. The decision to institute treatment of the patients should be made after a period of follow up, because therapy is often prolonged, and frequently ineffective. The reasons why some patients develop severe NTM diseases are not clear. Here we observed the involvement of latent tuberculosis infection (LTBI) in clinical and laboratory features of NTM diseases. We evaluated various tuberculosis-related inflammatory markers including osteopontin (OPN), pentraxin-3 (PTX-3), and soluble IL-2 receptor (sIL-2R) in NTM infected patients with or without LTBI. Eight NTM and 5 tuberculosis (TB) patients, and 5 healthy subjects were enrolled. Polymerase Chain Reaction (PCR) analysis confirmed the absence of tuberculosis specific gene (RD1 region), among clinical isolates from NTM patients. Interferon-γ (IFN-γ) release assay (IGRA) using Early Secreted Antigenic Target-6 (ESAT-6) and CFP-10, the RD1-encoded protein, was employed for determining LTBI. IGRA was positive in 4/8 NTM (NTM with LTBI, 50%) and 5/5 TB patients. Only 2 of 4 NTM with LTBI were under chemotherapy among all NTM patients, and others were followed up. The plasma levels of OPN, PTX3 and sIL-2R were significantly higher in NTM patients with LTBI than in those without LTBI (P < 0.05). The two patients under therapy showed the highest OPN levels that persisted after treatment. The increased inflammatory levels in NTM patients with LTBI indicate enhanced inflammatory reaction. Extensive therapy may be necessary in such patients.

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Inmunodiagnóstico y biomarcadores en tuberculosis

Guio¹,

Vilaplana²,

Cardona³

2011

Medicina Clínica

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High Numbers of Interferon-.GAMMA.-Producing T Cells and Low Titers of Anti-Tuberculous Glycolipid Antibody in Individuals with Latent Tuberculosis

Cited by 3 publications

References 30 publications

Diagnostic value of antibody responses to multiple antigens from Mycobacterium tuberculosis in active and latent tuberculosis

Diagnostic value of antibody responses to multiple antigens from Mycobacterium tuberculosis in active and latent tuberculosis

Distinct Clinical Features in Nontuberculous Mycobacterial Disease with or without Latent Tuberculosis Infection

Inmunodiagnóstico y biomarcadores en tuberculosis

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