High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorder

Breunis, M. Nadine; Kupka, Ralph; Nolen, Willem A.; Suppes, Trisha; Denicoff, Kirk D.; Leverich, Gabriele S.; Post, Robert M.; Drexhage, Hemmo A.

doi:10.1016/s0006-3223(02)01452-x

Cited by 129 publications

(92 citation statements)

References 46 publications

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“…Três encontraram níveis elevados em pacientes bipolares em quadros de mania 27,29,31 . Quatro estudos investigaram ní-veis de receptores solúveis de IL-6 e somente um observou alteração em relação aos controles 27 .…”

Section: Resultsunclassified

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Imunologia do transtorno bipolar

Barbosa

Huguet²,

Neves

et al. 2009

J. bras. psiquiatr.

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Palavras-chaveTranstorno bipolar, imunologia, citocinas, quimiocinas, interleucinas, interferon e fator de necrose tumoral-α. rEsumo objetivo: Pesquisas recentes têm implicado fatores imunes na patogênese de diversos transtornos neuropsiquiátricos. O objetivo do presente trabalho é revisar os trabalhos que investigaram a associação entre transtorno bipolar e alterações em parâmetros imunes. métodos: Artigos que incluíam as palavras-chave: "bipolar disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" e "tumor necrosis factor" foram selecionados em uma revisão sistemática da literatura. As bases de dados avaliadas foram MedLine e Scopus, entre os anos de 1980 e 2008. resultados: Foram identificados 28 trabalhos que estudaram alterações imunes em pacientes com transtorno bipolar. Seis artigos investigaram genes relacionados à resposta imune; cinco, autoanticorpos; quatro, populações leucocitárias; 13, citocinas e/ou moléculas relacionadas à resposta imune e seis, leucócitos de pacientes in vitro. Conclusões: Embora haja evidências na literatura correlacionando o transtorno bipolar a alterações imunes, os dados não são conclusivos. O transtorno bipolar parece estar associado a níveis mais elevados de autoanticorpos circulantes, assim como à tendência à ativação imune com produção de citocinas pró-inflamatórias e redução de parâmetros anti-inflamatórios. aBstraCt Objective: Emerging research has implicated immune factors in the pathogenesis of a variety of neuropsychiatric disorders. The objective of the present paper is to review the studies that investigated the association between bipolar disorder and immune parameters. Methods:Papers that included the keywords "bipolar to disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" and "tumor

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Section: Resultsunclassified

“…Segundo revisão da literatura, os estudos que avaliaram esses fatores antes do uso de medicamentos não apresentaram, em sua maioria, alterações dos parâmetros imunes, sugerindo que as alterações imunológicas seriam intrínsecas ao TB 27,28,[30][31][32]39,[40][41][42] . Entretanto, Padmos et al 21 …”

Section: Discussionunclassified

Imunologia do transtorno bipolar

Barbosa

Huguet²,

Neves

et al. 2009

J. bras. psiquiatr.

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“…Drexhage et al [17] reported an increased number of regulatory T cells in BD compared to controls. Changes in the number of circulating activated T cells and monocytes were also exhibited in BD patients when compared to healthy controls [5,15,16]. However, Karpiński et al [40] found no significant difference in the number of natural killer cells between BD patients and healthy controls.…”

Section: Discussionmentioning

confidence: 97%

“…It was shown that serum soluble IL-2 receptor, interferon-γ, and serum tumour necrosis factor (TNF)-α receptor 1 levels were increased in manic patients compared to euthymic patients and healthy controls [4,10,11]. Additionally, IL-6, TNF-α, and soluble IL-2 receptor were reported to be significantly increased in manic episodes compared to healthy controls [5,7]. On the other hand, Liu et al [18] found no relationship between manic patients and healthy controls regarding serum IL-2 levels.…”

Section: Discussionmentioning

confidence: 99%

“…The biological mechanisms of BD still remain unclear, but it can be effectively conceptualized as a multi-systemic inflammatory disease [3]. To date, changes in peripheral inflammatory markers have been reported in BD such as cytokine profiles [4][5][6][7][8][9][10][11], acute phase proteins [12][13][14], and lymphocyte cell activation [5,[15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder

Ayhan¹,

Çiçek²,

İnanlı³

et al. 2017

Psychiatry and Clinical Psychopharmacology

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Objectives: This study aims at researching the inflammatory cells and their ratios as inflammation markers in different phases of patients with bipolar disorder (BD). Methods: In this retrospective study, 79 manic, 61 depressed, 59 euthymic drug-naive patients with BD, and 86 control subjects have been evaluated for their complete blood count. Results: Neutrophil/lymphocyte ratio (NLR) was found to be significantly higher in manic, euthymic, and depressed patients with BD compared to control group. However, no difference was found between all patient and control groups regarding platelet/lymphocyte ratio (PLR). There was no difference among different phases of patient groups in terms of NLR and PLR. Conclusions: Our findings suggest that inflammatory process may have a role in all mood episodes of BD and NLR may be a useful trait inflammation marker for BD independent of mood episodes. However, further studies need to be conducted on the effect of inflammatory mechanisms on mood states of BD. ARTICLE HISTORY

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A subgroup of Tourette's patients overexpress specific natural killer cell genes in blood: A preliminary report

Lit

Gilbert

Walker

et al. 2007

American J of Med Genetics Pt B

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Gilles de la Tourette Syndrome (TS) is a heritable, neurodevelopmental disorder characterized by motor and vocal tics. As no single gene or region has emerged from standard linkage approaches, TS may result from several as-yet-unidentified genetic factors, and may also occur due to infection-triggered, autoimmune processes. Etiological or pathogenic differences might result in clinically indistinguishable TS subgroups. We have previously used whole genome human oligonucleotide microarrays in an attempt to identify patterns of gene expression in blood linked with TS. In this proof-of-principle study, we applied Principal Components Analysis to a previously collected set of 16 familial TS and 16 control blood samples to identify subgroups. Fourteen genes, primarily Natural Killer Cell (NK) genes, discriminated between TS and all controls. Granzyme B and NKG7 were confirmed using RT-PCR. Five probesets (four genes) reside in chromosomal regions previously linked to familial TS or obsessive-compulsive disorder. Using the 14 genes, a Principal Components Analysis as well as a cluster analysis identified a TS subgroup (n = 10/16) that overexpressed the NK genes. 7/10 subjects within this subgroup were diagnosed with attention-deficit hyperactivity disorder (ADHD), suggesting that this expression profile might be associated with TS and co-morbid ADHD. Principal Components Analysis of gene expression in blood may be useful for identifying subgroups of other complex neurodevelopmental diseases, and the gene expression profile identified in this study may provide a biomarker for at least one subgroup of heritable TS.

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High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorder

Cited by 129 publications

References 46 publications

Imunologia do transtorno bipolar

Imunologia do transtorno bipolar

Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder

A subgroup of Tourette's patients overexpress specific natural killer cell genes in blood: A preliminary report

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