High number of tumour-infiltrating lymphocytes is associated with apoptosis in non-small cell lung carcinoma

Abstract

Our results showed an association between lymphocytic infiltration and extent of apoptosis in NSCLC, suggesting that an attempt to suppress the growth of transformed tumour cells exists even when the tumour has reached an advanced stage.

Immune activation status of CD8+ T cells infiltrating non-small cell lung cancer

“…It is therefore conceivable that the immune reactivity of CD8+ T cells present at the tumor-host interface, in comparison to the effector function of intratumoral T lymphocytes, may be less hampered. Our results display a significant CD8+ T cell infiltration within the majority of lung tumors, however, in concordance with other studies [2,14,31] we failed to demonstrate an association between CD8+ T cell counts and the tumor histologic type and grade.…”

“…In humans, local IFN-␥ secretion from activated CD8+ T cells is associated with their in vivo efficacy [5][6][7] and has been explored extensively in a variety of clinical settings [8][9][10]. Although reports indicate that lung cancer cells can be recognized by autologous cytotoxic T cells (CTLs) and might, therefore, be susceptible to specific immunotherapy [11,12], the significance of TILs in lung cancer remains controversial [13][14][15]. Given the fact that patients with NSCLC exhibit high recurrence rates and poor long-term survival, novel tools are of need to identify those patients who may respond to adjunctive therapies, such as immunotherapy.…”

Preoperative lymphocyte count is an independent prognostic factor in node-negative non-small cell lung cancer

“…An increased number of tumor-infiltrating lymphocytes (TILs) is correlated with a favorable prognosis in cancer [26]. Cluster-of-differentiation (CD)8 + T cells have a pivotal role in tumor growth control by cytotoxic T-cell killing and apoptosis [27,28], and CD4 + T cells play a central role in orchestrating the immune response to cancers [29]. In NSCLC, the role of TILs is still controversial.…”

Prognostic impact of CD8 and programmed death-ligand 1 expression in patients with resectable non-small cell lung cancer

“…37 Indeed, CD8+T cells are most likely to be functionally relevant in NSCLC, as the number of apoptotic tumour cells is significantly higher in tumours with a high number of CD3+ and CD8+T cells. 38 Therefore, CD8+T lymphocytes comprise a well-established group of effector T cells with potent cytotoxic effects in cancer. 39 In addition, PD-L1-negative tumour cells promote tumour-reactive CD8+T-cell infiltration and proliferation, increased cytokine production, and enhanced cytolytic activity.…”