High Neutrophil Percentage-To-Albumin Ratio Can Predict Occurrence of Stroke-Associated Infection

Zhang, Haipeng; Wu, Ti; Tian, Xiaolin; Lyu, Panpan; Wang, Jianfei; Cao, Yang

doi:10.3389/fneur.2021.705790

Cited by 23 publications

(27 citation statements)

References 32 publications

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“…NPAR was discovered to be a new indicator for systemic infection and inflammation in humans 14,29 . The elevated NPAR levels are caused by an increase in neutrophil percentage and/or a reduction in albumin concentrations.…”

Section: Discussionmentioning

confidence: 99%

The neutrophil percentage‐to‐albumin ratio is related to the occurrence of diabetic retinopathy

Dai

Zhang

Pan

2022

Clinical Laboratory Analysis

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Background Among patients with diabetic retinopathy (DR), no proof was available to confirm the prognostic significance of the neutrophil percentage‐to‐albumin ratio (NPAR). We hypothesized that NPAR plays a role in the incidence of DR in diabetic patients. Methods We extracted all diabetes mellitus (DM) data from the National Health and Nutrition Examination Survey (NHANES) database between 1999 and 2018, NPAR was expressed as neutrophil percentage/albumin. Multivariable logistic regression and generalized additive model were utilized for the purpose of examining the correction between NPAR levels and DR. Subgroup analysis of the associations between NPAR and DR was carried out to investigate if the impact of the NPAR varied among different subgroups. Results An aggregate of 5850 eligible participants were included in the present research. The relationship between NPAR levels and DR was positive linear. In the multivariate analysis, following the adjustment for confounders (gender, white blood cell, age, monocyte percent, red cell distribution width, eosinophils percent, bicarbonate, body mass index, iron, glucose, basophils percent, total bilirubin, creatinine, and chloride), higher NPAR was an independent risk factor for DR compared to lower NPAR (OR, 95% CI: 1.18, 1.00–1.39; 1.24, 1.04–1.48). For the purpose of sensitivity analysis, we found a trend of consistency (p for trend: 0.0190). The results of the subgroup analysis revealed that NPAR did not exert any statistically significant interactions with any of the other DR risk variables. Conclusions Elevated NPAR is associated with an elevated risk of occurrence of DR in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

The neutrophil percentage‐to‐albumin ratio is related to the occurrence of diabetic retinopathy

Dai

Zhang

Pan

2022

Clinical Laboratory Analysis

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“…In 6 cohort studies [ 11 , 20 , 22 , 24 , 27 , 31 ] with 2,416 patients with stroke, NLR levels in the PSI group were compared to those in the nonpoststroke infection (NPSI) group, with 876 patients diagnosed with PSI after the follow-up period. Because the included studies were statistically heterogeneous ( I 2 = 89.7%, P value < 0.001), the analysis was conducted using the random effect model ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…In the subgroup analysis, according to study design, three were retrospective studies [ 22 , 24 , 31 ] with 779 patients with stroke, 164 of whom developed PSI. Three were prospective studies [ 11 , 20 , 27 ] with 1,637 patients with stroke, 712 of whom developed PSI.…”

Section: Resultsmentioning

confidence: 99%

“…[10, 12, 14, 18, 22-25, 28, 30-32] and 13 were prospective [4, 9, 11, 13, 15-17, 19-21, 26, 27, 29]. Among 25 studies, 15 were included in the meta-analysis; nine were retrospective [10,14,22,24,25,28,[30][31][32], and six were prospective [11,13,20,26,27,29]. In terms of document language, all of the documents were written in the English language.…”

Section: Statistical Analysis Standard Mean Differences (Smds)mentioning

confidence: 99%

“…In addition, the scale named NOS was used to assess the quality of the included research (Tables 1 and 2). In total, six studies compared NLR levels in PSI patients and controls [11,20,22,24,27,31], and nine studies reported NLR levels in the PSP group against controls [10,13,14,25,26,[28][29][30]32].…”

Section: Statistical Analysis Standard Mean Differences (Smds)mentioning

confidence: 99%

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The Neutrophil to Lymphocyte Ratio in Poststroke Infection: A Systematic Review and Meta-Analysis

et al. 2022

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Ischemic and hemorrhagic strokes have multiple downstream consequences for patients. One of the most critical is poststroke infection (PSI). The goal of this systematic review and meta-analysis was to critically evaluate the literature regarding the use of the neutrophil to lymphocyte ratio (NLR) as a reliable means to detect early PSI development, particularly poststroke pneumonia (PSP) development to help clinicians institute early interventions and improve outcomes. The following were the inclusion criteria: (1) cross-sectional, case-control, and cohort studies; (2) studies comparing NLR data from PSI or PSP patients to controls; and (3) studies with a control group of stroke patients without infection. There was not any language or publication preference. The Newcastle-Ottawa Scale was used by two writers to assess the quality of the included studies. We assessed the certainty of the associations with GRADE methods. Web of Science, PubMed, and Scopus were searched, and 25 studies were included in the qualitative review. Among them, 15 studies were included in the meta-analysis. Standardized mean difference (SMD) was reported with a 95% confidence interval (CI) for the NLR levels. Patients with PSI had significantly higher NLR levels than stroke patients without infection ( SMD = 1.08 ; CI 95 % = 0.78 ‐ 1.39 , P value < 0.001). In addition, the NLR levels of the stroke patients with pneumonia were significantly higher than those without pneumonia ( SMD = 0.98 ; CI 95 % = 0.81 ‐ 1.14 , P value < 0.001). However, data extracted from the qualitative review suggested that NLR could not predict urinary tract infection, sepsis, or ventriculitis in stroke patients. Our study indicated that NLR could be recommended as an inexpensive biomarker for predicting infection, particularly pneumonia, in stroke patients. It can help clinicians institute early interventions that can reduce PSI and improve outcomes.

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Therapeutic effect and study of human umbilical cord blood mononuclear cells in patients with ischaemic bowel disease

Cai,

Li,

Gao

et al. 2024

Sci Rep

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Ischaemic bowel disease (ICBD) is a group of intestinal ischaemia syndromes caused by various aetiologies of reduced intestinal blood flow or vascular occlusion. ICBD can present as abdominal pain, bloody stool, and diarrhoea. This disease often occurs in middle-aged and elderly individuals with cardiovascular and cerebrovascular diseases. The incidence of ischaemic bowel disease has been increasing for decades, and it is difficult to diagnose, resulting in rapid disease progression and a high mortality rate. Therefore, fully understanding this disease, improving the diagnosis rate of this disease, and finding appropriate treatment methods are urgently needed to improve the condition and prognosis of patients. Umbilical cord blood stem cells are accessible, have weak immunogenicity, and have various biological functions, such as angiogenesis, inflammation and immune regulation. Many studies have confirmed that cord blood stem cells can relieve ischaemia, and these cells have attracted tremendous amounts of attention in regenerative medicine in recent years. In this paper, we discuss the clinical characteristics of ICBD, analyse the characteristics of human umbilical cord blood mononuclear cells (HUCB-MNCs), and use its to treat ischaemic bowel disease. Additionally, we compare the clinical manifestations and related indicators before and after treatment to evaluate the efficacy and safety of these methods.

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High Neutrophil Percentage-To-Albumin Ratio Can Predict Occurrence of Stroke-Associated Infection

Cited by 23 publications

References 32 publications

The neutrophil percentage‐to‐albumin ratio is related to the occurrence of diabetic retinopathy

The neutrophil percentage‐to‐albumin ratio is related to the occurrence of diabetic retinopathy

The Neutrophil to Lymphocyte Ratio in Poststroke Infection: A Systematic Review and Meta-Analysis

Therapeutic effect and study of human umbilical cord blood mononuclear cells in patients with ischaemic bowel disease

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