High neuroticism and depressive temperament are associated with dysfunctional regulation of the hypothalamic–pituitary–adrenocortical system in healthy volunteers

Zobel, Astrid; Barkow, Katrin; Schulze-Rauschenbach, Svenja; Widdern, Olrik von; Metten, Martin; Pfeiffer, U.; Schnell, Susanne; Wagner, Michael; Maier, Wolfgang

doi:10.1111/j.1600-0447.2004.00313.x

Cited by 90 publications

(77 citation statements)

References 26 publications

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“…In the current study, our volunteers were two times stimulated within the same time schedule and during our HF-rTMS protocol all subjects performed standard cognitive tasks before T 1 and also between T 2 and T 3 . Our AUCi results are in line with healthy volunteer studies incorporating individual information which observed a stronger HPAsystem reactivity in individuals scoring higher on neuroticism or harm avoidance, both personality features closely linked to anxiety proneness (Zobel et al, 2004;Tyrka et al, 2008).…”

Section: Discussionsupporting

confidence: 78%

“…It has to be noticed that in our sample no participants were diagnosed with any anxiety or mood disorders and of course it remains questionable whether rTMS effects observed in healthy volunteers can be transferred to neurobiological rTMS effects found in psychiatric patients (Zwanzger et al, 2009). Other individual differences, such as state anxiety and personality features (Boudarene et al, 2002;Zobel et al, 2004;Tyrka et al, 2007Tyrka et al, , 2008Hauner et al, 2008) might be involved in the HF-rTMS related HPAsystem reactivity.…”

Section: Discussionmentioning

confidence: 99%

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Baseline ‘state anxiety’ influences HPA-axis sensitivity to one sham-controlled HF-rTMS session applied to the right dorsolateral prefrontal cortex

Baeken¹,

Vanderhasselt²,

Raedt³

2011

Psychoneuroendocrinology

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2 SummaryAlthough negative results have been reported, an important aspect of the physiology of repetitive Transcranial Magnetic Stimulation (rTMS) could be related to the endocrinological response of the hypothalamic-pituitaryadrenal (HPA) axis, such as cortisol secretion. Because endocrinological responses are influenced by anxiety states, this could influence the effect of rTMS in healthy individuals. In this sham-controlled, "single blind" crossover study, we examined whether one session of HF-rTMS could affect the HPA-system, when taking into account individual state anxiety scores based on the State-Trait Anxiety Inventory (STAI). Twenty-four healthy rTMS naïve females received one sham-controlled high frequency (HF)-rTMS session delivered on the right dorsolateral prefrontal cortex (DLPFC). The Profile of Mood States (POMS) questionnaire, together with salivary cortisol samples, was collected before, just after and 30 minutes post HF-rTMS. To examine whether state anxiety could influence endocrinological outcome measurements, we administered the STAI-state just before each HF-rTMS experiment started. Based on the POMS questionnaire, no mood changes were observed.Without taking individual state anxiety scores into account, one sham-controlled right-sided HF-rTMS session did not influence the HPA-system. When taking into account individual STAI-state scores, we found that healthy women scoring higher on the STAI-state displayed a significantly more sensitive HPA-system, resulting in salivary cortisol concentration increases after real HF-rTMS, compared to those scoring lower on this anxiety scale. Our results indicate that healthy women scoring high on state anxiety display a more sensitive HPAsystem when receiving one right-sided HF-rTMS session. Our findings suggest that the incorporation of individual anxiety states in experimental rTMS research could add further information about its neurobiological influences on the HPA-system.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Baseline ‘state anxiety’ influences HPA-axis sensitivity to one sham-controlled HF-rTMS session applied to the right dorsolateral prefrontal cortex

Baeken¹,

Vanderhasselt²,

Raedt³

2011

Psychoneuroendocrinology

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“…These findings can be seen to be in keeping with other research, such as the work of Habra and colleagues, who also observed an association between neuroticism and an index of HPA reactivity, as measured by cortisol reactivity to a mental arithmetic task (Habra et al, 2003). Similarly, Zobel et al (2004) reported an association between neuroticism and reactivity of the HPA axis, as measured by cortisol responses to the dexamethasone suppression test.…”

Section: Discussionsupporting

confidence: 78%

“…In contrast, neuroticism is among the most widely investigated trait measures in this area (Roy, 1996;Schommer et al, 1999;Hanson et al, 2000;Habra et al, 2003;Zobel et al, 2004). Although, here too, the evidence is equivocal.…”

Section: Discussionmentioning

confidence: 82%

Psychosocial factors associated with indices of cortisol production in women with breast cancer and controls

Vedhara

Tuinstra

Miles

et al. 2006

Psychoneuroendocrinology

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Psychosocial factors associated with indices of cortisol production in women with breast cancer and controls Vedhara, K.; Tuinstra, Jolanda; Miles, J.N.V.; Sanderman, Robbert; Ranchor, Adelita V. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. SummaryThe present study was designed to (i) explore which psychosocial factors were associated with indices representing the early morning peak, diurnal cortisol rhythm and area under the curve (AUC); (ii) examine whether the relationships between psychosocial functioning and these cortisol indices were consistent and (iii) explore whether these relationships were influenced by the clinical status of the participant. Newly diagnosed breast cancer patients (nZ85) and healthy control women (nZ59) were recruited. State and trait measures of psychosocial functioning (i.e. anxiety, depression, distress, neuroticism, extraversion, marital satisfaction and mastery) were undertaken. In addition, all participants provided four saliva samples (on waking, 30 min later, between 11 and 1 p.m., before lunch and between 8 and 10 p.m., at least 2 h after evening meal) over two consecutive days to assess cortisol levels. The results highlighted the divergent nature of the four cortisol indices; revealed the presence of some significant relationships between the psychosocial measures and the cortisol indices; but highlighted inconsistencies in the relationships evident for patients and those observed for control women. Q

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“…This behavioral trait may be analogous to certain human personality traits associated with naturally-elevated glucococorticoid production in certain individuals (Arranz et al, 2007;Zobel et al, 2004). The results of the current study suggest that females with such personalities may physiologically mimic the effects of chronic environmental stress.…”

Section: Discussionmentioning

confidence: 73%

Female temperament, tumor development and life span: Relation to glucocorticoid and tumor necrosis factor α levels in rats

Cavigelli

Bennett

Michael

et al. 2008

Brain, Behavior, and Immunity

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Behavioral characteristics closely associated with specific physiological profiles present an important area of research in understanding health disparities. In particular, glucocorticoid overproduction may be an important factor moderating disease progression; natural variance in production of this steroid has been proposed as one mechanism underlying individual differences in health and disease. In the current paper, we examined immune parameters in female rats of two different behavioral types previously shown to have differential glucocorticoid production and life spans. We categorized young female rats according to their behavioral response to novelty (high-or low-locomotion), and compared their glucocorticoid production, adrenal size, thymus size, tumor necrosis factor-α (TNF-α) production, tumor development and life span. As expected, high-locomotion females produced more glucocorticoids and had larger adrenal glands during young adulthood than did low-locomotion females. High-locomotion females had significantly smaller thymuses and reduced TNF-α levels compared to low-locomotion, suggesting altered immune function in young adulthood. Finally, highlocomotion females had shorter life spans than did low-locomotion females, and this was particularly true in females that developed pituitary tumors, but not in those that developed mammary tumors. These results, along with other published findings, suggest that high-locomotion rodent females experience life-long elevations in glucocorticoid responses to novelty, and that these elevated levels may be comparable to chronic stress. This naturally-occurring endocrine profile may influence immune responses which in turn could affect disease susceptibility. Variance in immune function across personality types may be partially moderated by natural variance in glucocorticoid production.

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High neuroticism and depressive temperament are associated with dysfunctional regulation of the hypothalamic–pituitary–adrenocortical system in healthy volunteers

Abstract: This constellation may propose that HPA dysregulation is the endocrinological basis for neuroticism and depressive temperament; this result supports the view that distinct personality factors and HPA vulnerability interact in mediating depression.

Cited by 90 publications

References 26 publications

Baseline ‘state anxiety’ influences HPA-axis sensitivity to one sham-controlled HF-rTMS session applied to the right dorsolateral prefrontal cortex

Baseline ‘state anxiety’ influences HPA-axis sensitivity to one sham-controlled HF-rTMS session applied to the right dorsolateral prefrontal cortex

Psychosocial factors associated with indices of cortisol production in women with breast cancer and controls

Female temperament, tumor development and life span: Relation to glucocorticoid and tumor necrosis factor α levels in rats

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