High morbidity and mortality of chronic viral liver disease in HIV-infected individuals in Spain

Soriano, Vincent; García‐Samaniego, J.; Gutiérrez, M.; Bravo, R.; González-Lahoz, Juan

doi:10.1016/s0163-4453(94)94440-7

Cited by 15 publications

(5 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seven papers provided data from eras pre- and post- HAART introduction [11, 17-22]. For pre-HAART analysis, 10 studies were excluded for one or more of the following reasons: 1) AIDS and overall mortality were combined as a single endpoint [17, 23, 24], 2) lack of HCV-negative control [21, 25, 26] or 3) data were not able to be pooled [22, 27-29]. As a result, data were extracted for 10 studies [11, 18-20, 30-35].…”

Section: Resultsmentioning

confidence: 99%

Meta‐Analysis: Increased Mortality Associated with Hepatitis C in HIV‐Infected Persons Is Unrelated to HIV Disease Progression

et al. 2009

View full text Add to dashboard Cite

Background It is unclear whether coinfection with HCV increases mortality in HIV patients in the HAART era. Using a meta-analysis, we estimated the effect of HCV on HIV disease progression and overall mortality in the pre- and HAART era. Method PubMed and EMBASE were searched for studies published until April 30, 2008. Additional studies were identified from cited references. Studies reporting disease progression or mortality in HCV/HIV coinfected patients were selected. Cross sectional studies, studies without HCV negative controls and studies among children and/or post-liver transplant were excluded. Two authors reviewed articles and extracted data on demographics of study populations and risk estimates. Meta-regression was used to explore heterogeneity. Results 10 pre-HAART studies and 27 HAART era studies were selected. In the pre-HAART era, the risk ratio for overall mortality among HCV/HIV coinfected patients was 0.68 (95% CI: 0.53~0.87) compared to patients with HIV infection alone. In the HAART era, the risk ratio was 1.12 (95% CI: 0.82~1.51) for AIDS-defining events and 1.35 (95% CI: 1.11~1.63) for overall mortality in coinfected patients compared to HIV monoinfection. Conclusions HCV coinfection did not increase mortality in HIV patients before the introduction of HAART. In contrast, HCV coinfection increases the risk of mortality but not AIDS-defining events compared to HIV infection alone in the HAART era. Future studies should determine whether successfully treated HCV could reduce this excess risk of mortality in coinfected patients.

show abstract

Section: Resultsmentioning

confidence: 99%

Meta‐Analysis: Increased Mortality Associated with Hepatitis C in HIV‐Infected Persons Is Unrelated to HIV Disease Progression

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Among HIV/HBV co-infected patients, the presence of HDV infection has been associated with an unfavorable effect on the severity of liver disease by various authors. [19][20][21] It has been suggested that patients co-infected with HIV and HBV should be tested for anti-HDV antibodies (IgG and IgM), particularly if they have lived in an area where HDV is endemic, and especially in countries where routine immunization against HBV is not common. Ideally, HDV RNA should be detected and the viral load level should be determined in patients who are positive for HDV antibody (anti-HD).…”

mentioning

confidence: 99%

Hepatitis delta in HIV/HBV co-infected patients in Brazil: is it important?

Mendes-Corrêa

Gomes‐Gouvêa

Alvarado-Mora

et al. 2011

International Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…In fact, associated liver failure in coinfected HIV positive patients is one of the leading causes of death in men between the ages of 25 and 44 years. 8,9 Whereas OLT is considered a standard therapeutic modality for the treatment of nearly all ESLD, patients with HIV generally have been excluded despite the improvement in survival since the implementation of the HAART regimen. This exclusion is a result of the pre-HAART fears of disease progression and the scarcity of organs.…”

mentioning

confidence: 99%

Orthotopic liver transplantation in patients with human immunodeficiency virus and end-stage liver disease

Neff

Bonham

Tzakis

et al. 2003

Liver Transplantation

152

View full text Add to dashboard Cite

High morbidity and mortality of chronic viral liver disease in HIV-infected individuals in Spain

Cited by 15 publications

References 3 publications

Meta‐Analysis: Increased Mortality Associated with Hepatitis C in HIV‐Infected Persons Is Unrelated to HIV Disease Progression

Meta‐Analysis: Increased Mortality Associated with Hepatitis C in HIV‐Infected Persons Is Unrelated to HIV Disease Progression

Hepatitis delta in HIV/HBV co-infected patients in Brazil: is it important?

Orthotopic liver transplantation in patients with human immunodeficiency virus and end-stage liver disease

Contact Info

Product

Resources

About