High-Molecular-Weight Hypromellose from Three Different Suppliers: Effects of Compression Speed, Tableting Equipment, and Moisture on the Compaction

Grdešič, Peter; Paudel, Amrit; Ilić, Ilija

doi:10.1208/s12249-020-01688-y

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…The bulk (0.24–0.31 g/cm 3 ), tap (0.36–0.45 g/cm 3 ), and true densities (0.30–0.33 g/cm 3 ) of all the tested polymers were relatively similar. These values were similar to that reported by others [ 18 ]. Bonucel had the lowest bulk density (0.24 g/cm 3 ), followed closely by the Methocel DC and CR grades (0.25 g/cm 3 ).…”

Section: Resultssupporting

confidence: 93%

“…Given that chemistry and viscosity grades are equivalent, it could be considered that the polymer hydration and consequent drug release rate will be equivalent, hence, that behaviour has not been investigated in this work. Recently, the mechanical properties of HPMC from K4M and K100M from three vendors have been investigated, with a focus on compression speed [ 18 ]. The DC and CR grades were investigated for one vendor only (Methocel grades of K4M and K100M).…”

Section: Introductionmentioning

confidence: 99%

“…The DC and CR grades were investigated for one vendor only (Methocel grades of K4M and K100M). The authors found the Benecel and Methocel K100M grades had the best compaction properties [ 18 ]. The material attributes of HPMC from two different vendors with a focus on viscosity grades (K4M, K15M, and K100M) have also been explored.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Evaluation of the Powder and Tableting Properties of Regular and Direct Compression Hypromellose from Different Vendors

Mawla,

Alshafiee,

Gamble

et al. 2023

Pharmaceutics

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Hypromellose, a widely used polymer in the pharmaceutical industry, is available in several grades, depending on the percentage of substitution of the methoxyl and hydroxypropyl groups and molecular weight, and in various functional forms (e.g., suitable for direct compression tableting). These differences can affect their physicomechanical properties, and so this study aims to characterise the particle size and mechanical properties of HPMC K100M polymer grades from four different vendors. Eight polymers (CR and DC grades) were analysed using scanning electron microscopy (SEM) and light microscopy automated image analysis particle characterisation to examine the powder’s particle morphology and particle size distribution. Bulk density, tapped density, and true density of the materials were also analysed. Flow was determined using a shear cell tester. Flat-faced polymer compacts were made at five different compression forces and the mechanical properties of the compacts were evaluated to give an indication of the powder’s capacity to form a tablet with desirable strength under specific pressures. The results indicated that the CR grades of the polymers displayed a smaller particle size and better mechanical properties compared to the DC grade HPMC K100M polymers. The DC grades, however, had better flow properties than their CR counterparts. The results also suggested some similarities and differences between some of the polymers from the different vendors despite the similarity in substitution level, reminding the user that care and consideration should be given when substitution is required.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%