High molecular weight adiponectin reduces glucolipotoxicity-induced inflammation and improves lipid metabolism and insulin sensitivity via APPL1-AMPK-GLUT4 regulation in 3T3-L1 adipocytes

Pandey, Gautam Kumar; Vadivel, Sangeetha; Raghavan, Srividhya; Mohan, Viswanathan; Balasubramanyam, Muthuswamy; Gokulakrishnan, Kuppan

doi:10.1016/j.atherosclerosis.2019.07.011

Cited by 31 publications

(18 citation statements)

References 39 publications

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“…In addition, adiponectin, an adipose‐tissue‐derived hormone plays an important role in the regulation of lipid metabolism and insulin sensitivity and also possesses anti‐inflammatory properties. [ 33 ] As per previous reports, adiponectin‐activated AdipoR2 activates both AMPK signaling and PPARα. [ 34 ] As a result, restorative effects of adiponectin against lipo‐inflammation have been reported by inhibiting the release of plethora of pro‐inflammatory cytokines, notably TNF‐α and IL‐6.…”

Section: Discussionsupporting

confidence: 67%

Anti‐Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy

Subramanian

Shanmugamprema

Subramani

et al. 2021

Molecular Nutrition Food Res

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Occurrence of obesity and its associated metabolic disorders continues to escalate. The present study evaluates the anti-obesity effects of ethanolic fruit extract of Terminalia chebula (EETC) on high fat diet induced obese mice. The bioactive compounds present in the EETC is evaluated by Fourier-transform infrared (FT-IR), Gas chromatography-mass spectrometry (GC-MS), and Liquid chromatography-mass spectrometry (LC-MS) analysis. The effects of EETC on energy intake, glucose tolerance, and various biochemical parameters were analyzed using laboratory mice. Relative gene expression of Fatty acid synthase (FAS), Peroxisome proliferator-activated receptors (PPAR ), Carnitine palmitoyltransferase-1 (CPT-1), Tumor necrosis factor alpha (TNF-) as well as Interleukin 6 (IL-6) were analyzed in liver and adipose tissues. The findings reveal the hypolipidemic and anti-obesity potential of EETC on high fat fed obese mice. EETC exerts its anti-obesity effects by suppressing lipogenesis through reduction in lipogenic enzyme (FAS) expression, increased fatty acid oxidation via PPAR and CPT-1 and by triggering the anti-inflammatory responses. To our knowledge, this is the first report of the effect of EETC on PPAR and CPT-1 in in vivo.

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Section: Discussionsupporting

confidence: 67%

Anti‐Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy

Subramanian

Shanmugamprema

Subramani

et al. 2021

Molecular Nutrition Food Res

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“…This suggested that HMW decreases inflammation and oxidative stress. HMW treatment improved glucose homeostasis and reduced inflammation by regulating APPL1-AMPK-GLUT4 signaling in 3T3-L1 adipocytes subjected to glucolipotoxicity [132]. In addition, some studies indicated that HMW has a negative relationship with inflammatory markers in type 2 diabetic patients [133][134][135] and obese people [136].…”

Section: Issues Related To Hmw: Pro-inflammatory or Anti-inflammatorymentioning

confidence: 99%

Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases

Choi

Doss

Kim

2020

IJMS

282

231

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Adiponectin is the richest adipokine in human plasma, and it is mainly secreted from white adipose tissue. Adiponectin circulates in blood as high-molecular, middle-molecular, and low-molecular weight isoforms. Numerous studies have demonstrated its insulin-sensitizing, anti-atherogenic, and anti-inflammatory effects. Additionally, decreased serum levels of adiponectin is associated with chronic inflammation of metabolic disorders including Type 2 diabetes, obesity, and atherosclerosis. However, recent studies showed that adiponectin could have pro-inflammatory roles in patients with autoimmune diseases. In particular, its high serum level was positively associated with inflammation severity and pathological progression in rheumatoid arthritis, chronic kidney disease, and inflammatory bowel disease. Thus, adiponectin seems to have both pro-inflammatory and anti-inflammatory effects. This indirectly indicates that adiponectin has different physiological roles according to an isoform and effector tissue. Knowledge on the specific functions of isoforms would help develop potential anti-inflammatory therapeutics to target specific adiponectin isoforms against metabolic disorders and autoimmune diseases. This review summarizes the current roles of adiponectin in metabolic disorders and autoimmune diseases.

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“…It has been found that, under subacute Cd exposure, Cd-treated rats showed a significant reduction in GLUT4 mRNA and GLUT4 Protien levels in adipocytes (Han et al 2003). To investigate the adiponectin effects, dysfunctional 3T3-L1 adipocytes (with low expression level of AdipoR2, GLUT4, and high inflammation) was treated with adiponectin (Pandey et al 2019). As a result, adiponectin treatment showed an advantageous effect in enhancing glucose homeostasis and reducing inflammation.…”

Section: Cadmium and Adiponectinmentioning

confidence: 99%

“…As a result, adiponectin treatment showed an advantageous effect in enhancing glucose homeostasis and reducing inflammation. This is mediated via the key signaling molecule of adiponectin signals transduction (APPL-1) that regulates AMPK phosphorylation (Pandey et al 2019). Altogether, this reflects the importance and the beneficial role of adiponectin in the maintenance of glucose homeostasis and fat storage function.…”

Section: Cadmium and Adiponectinmentioning

confidence: 99%

Cadmium: An Emerging Role in Adipose Tissue Dysfunction

et al. 2021

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Cadmium (Cd) is a toxic heavy metal that is widespread in the environment due to the substantial anthropogenic inputs from the agriculture and industrial sectors. The toxic impact of Cd adversely affects human health and is linked with endocrine disruption, carcinogenicity, diabetes-related diseases, and metabolic disorder. One of the main characterizations of Cd is bioaccumulation where its half-life reaches 40 years with an unknown biological role. Several organs were found to be targets for Cd accumulation such as the liver, kidneys, and adipose tissue. Adipose tissue (AT) is a dynamic organ that plays a significant role in the body’s homeostasis through the maintenance of energy storage. Another vital function for AT is the secretion of adipokines which provides a metabolic cross-talk with the whole body’s organs. Cd is found to adversely impact the function of AT. This includes the disruption of adipogenesis, lipogenesis, and lipolysis. As a consequence, dysfunctional AT has disruptive patterns of adipokines secretions. The main adipokines produced from AT are leptin and adiponectin. Both were found to be significantly declined under the Cd exposure. Additionally, adipose tissue macrophages can produce either anti-inflammatory markers or pro-inflammatory markers depending on the local AT condition. Cadmium exposure was reported to upregulate pro-inflammatory markers and downregulate anti-inflammatory markers. However, the exact mechanisms of Cd’s adverse role on AT structure, function, and secretion patterns of adipokines are not totally clarified. Therefore, in this review, we present the current findings related to Cd detrimental effects on adipose tissues.

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High molecular weight adiponectin reduces glucolipotoxicity-induced inflammation and improves lipid metabolism and insulin sensitivity via APPL1-AMPK-GLUT4 regulation in 3T3-L1 adipocytes

Cited by 31 publications

References 39 publications

Anti‐Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy

Anti‐Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy

Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases

Cadmium: An Emerging Role in Adipose Tissue Dysfunction

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