High-Molecular-Weight Adiponectin in Children Born Small- or Appropriate-for-Gestational-Age

Ibáñez, Lourdes; López‐Bermejo, Abel; Díaz, Marta; Angulo, Mario; Sebastiani, Giorgia; Zegher, Francis de

doi:10.1016/j.jpeds.2009.03.030

Cited by 18 publications

(11 citation statements)

References 10 publications

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“…We found a similar chromatographic pattern of adiponectin fractions in AGA and SGA subjects, during the first year of life, confirming the absence of modifications in total circulating adiponectin. Furthermore, in other recent studies by Ibanez et al [41,42], the authors show comparable levels of HMW adiponectin in AGA and SGA children at age two; the HMW adiponectin concentrations decrease and become significantly lower in SGA children only at age four.…”

Section: Discussionmentioning

confidence: 59%

“…At one year of age, no statistically significant difference is present in adiponectin levels between AGA and SGA infants, indicating that the long-term risk of diabetes, which has been reported to be associated with low adiponectin levels in prepubertal children [40], is the same in the two groups at this time. In fact, a recent study suggests that the negative correlation between high molecular weight (HMW) adiponectinaemia and fasting insulin levels emerges between two and six years of age and only during this period could a condition of insulin resistance be evidenced [41]. …”

Section: Discussionmentioning

confidence: 99%

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Role of adiponectin and leptin on body development in infants during the first year of life

et al. 2010

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BackgroundThe control of growth and nutritional status in the foetus and neonate is a complex mechanism, in which also hormones produced by adipose tissue, such as adiponectin and leptin are involved. The aim of this study was to evaluate levels of adiponectin, leptin and insulin in appropriate (AGA) and small for gestational age (SGA) children during the 1st year of life and to correlate these with auxological parameters.MethodsIn 33 AGA and 29 SGA infants, weight, length, head circumference, glucose, insulin, adiponectin and leptin levels were evaluated at the second day of life, and at one, six and twelve months, during which a portion of SGA could show catch-up growth (rapid growth in infants born small for their gestational age).ResultsBoth total and isoform adiponectin levels were comparable between AGA and SGA infants at birth and until age one year. These levels significantly increased from birth to the first month of life and then decreased to lower values at 1 year of age in all subjects. Circulating leptin concentrations were higher in AGA (2.1 ± 4.1 ng/ml) than in SGA neonates (0.88 ± 1.03 ng/ml, p < 0.05) at birth, then similar at the 1st and the 6th month of age, but they increased in SGA from six months to one year, when they showed catch-up growth. Circulating insulin levels were not statistically different in AGA and SGA neonates at any study time point. Insulin levels in both AGA and SGA infants increased over the study period, and were significantly lower at birth compared to one, six and 12 months of age.ConclusionsDuring the first year of life, in both AGA and SGA infants a progressive decrease in adiponectin levels was observed, while a difference in leptin values was correlated with the nutritional status.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Role of adiponectin and leptin on body development in infants during the first year of life

et al. 2010

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“…Other methods have been described (6)(7)(8)(9)(10)(11). In brief, birth weight and gestational age were obtained from hospital records.…”

Section: Methodsmentioning

confidence: 99%

“…Preliminary reports on this cohort disclosed the early development of insulin resistance and body adiposity (age 2, 3, and 4 years) (6) and the appearance of visceral adiposity and hypoadiponectinemia (age 2, 4, and 6 years) (7,8).…”

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confidence: 92%

Catch-up growth in girls born small for gestational age precedes childhood progression to high adiposity

Ibáñez

López‐Bermejo

Díaz

et al. 2011

Fertility and Sterility

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“…In parallel, we assessed circulating IGF-I, a prime endocrine marker for which levels are known to be lower in AGA infants receiving BRF than in those receiving FOF (10–12). Finally, we measured the circulating levels of high-molecular-weight (HMW) adiponectin, an adipokine that is abundantly present in the fetus (13,14) and is a sensitive marker of SGA-related features from early childhood onwards (15–17). …”

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confidence: 99%

Body Composition and Circulating High-Molecular-Weight Adiponectin and IGF-I in Infants Born Small for Gestational Age

et al. 2012

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Prenatal growth restraint, if followed by postnatal overweight, confers risk for adult disease including diabetes. The mechanisms whereby neonatal nutrition may modulate such risk are poorly understood. We studied the effects of nutrition (breast-feeding [BRF] vs. formula-feeding [FOF]) on weight partitioning and endocrine state (as judged by high-molecular-weight [HMW] adiponectin and IGF-I) of infants born small for gestational age (SGA). Body composition (by absorptiometry), HMW adiponectin, and IGF-I were assessed at birth and 4 months in BRF infants born appropriate for gestational age (AGA; n = 72) and SGA infants receiving BRF (n = 46) or FOF (n = 56), the latter being randomized to receive a standard (FOF1) or protein-rich formula (FOF2). Compared with AGA-BRF infants, the catchup growth of SGA infants was confined to lean mass, independently of nutrition. Compared with AGA-BRF infants, SGA-BRF infants had normal HMW adiponectin and IGF-I levels at 4 months, whereas SGA-FOF infants had elevated levels of HMW adiponectin (particularly SGA-FOF1) and IGF-I (particularly SGA-FOF2). In conclusion, neonatal nutrition seems to influence endocrinology more readily than body composition of SGA infants. Follow-up will disclose whether the endocrine abnormalities in SGA-FOF infants can serve as early markers of an unfavorable metabolic course and whether they may contribute to design early interventions that prevent subsequent disease, including diabetes.

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High-Molecular-Weight Adiponectin in Children Born Small- or Appropriate-for-Gestational-Age

Cited by 18 publications

References 10 publications

Role of adiponectin and leptin on body development in infants during the first year of life

Role of adiponectin and leptin on body development in infants during the first year of life

Catch-up growth in girls born small for gestational age precedes childhood progression to high adiposity

Body Composition and Circulating High-Molecular-Weight Adiponectin and IGF-I in Infants Born Small for Gestational Age

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