High-mobility group box 1 protein (HMGB1) from Cherry Valley duck mediates signaling pathways and antiviral activity

Hou, Xiaolan; Liu, Gen; Zhang, Huihui; Hu, Xiaofang; Zhang, Xinyue; Han, Fei; Cui, Huizhen; Luo, Jinjian; Ru, Guo; Li, Rong; Li, Ning; Wei, Liangmeng

doi:10.1186/s13567-020-00742-8

Cited by 18 publications

(12 citation statements)

References 42 publications

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“…Meanwhile, NLRP3 and NLRC5 were found to be involved in DTMUV infection [82]. HMGB proteins including HMGB1 and HMGB3 have been reported to affect DTMUV replication as well [102,103]. Although various PRRs might be involved in DTMUV infection, only the expression changes of these PRRs were focused on, and their specific function needs further investigation.…”

Section: Other Prrs Relevant To Dtmuv Infectionmentioning

confidence: 99%

Innate immune responses to duck Tembusu virus infection

Zhao

Yang

et al. 2020

Vet Res

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The disease caused by duck Tembusu virus (DTMUV) is characterized by severe egg-drop in laying ducks. Currently, the disease has spread to most duck-raising areas in China, leading to great economic losses in the duck industry. In the recent years, DTMUV has raised some concerns, because of its expanding host range and increasing pathogenicity, as well as the potential threat to public health. Innate immunity is crucial for defending against invading pathogens in the early stages of infection. Recently, studies on the interaction between DTMUV and host innate immune response have made great progress. In the review, we provide an overview of DTMUV and summarize current advances in our understanding of the interaction between DTMUV and innate immunity, including the host innate immune responses to DTMUV infection through pattern recognition receptors (PRRs), signaling transducer molecules, interferon-stimulated genes (ISGs), and the immune evasion strategies employed by DTMUV. The aim of the review is to gain an in-depth understanding of DTMUV pathogenesis to facilitate future studies.

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Section: Other Prrs Relevant To Dtmuv Infectionmentioning

confidence: 99%

Innate immune responses to duck Tembusu virus infection

Zhao

Yang

et al. 2020

Vet Res

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“…Note: The SDHZYC strain was marked with filled circles hemorrhage and necrosis in the liver. There are several notable different properties between classical MDRV and NDRV, including different antigenicity by cross-neutralization tests, host species differences, pathogenic properties, protein profiles [27][28][29], electropherotypes, and genomic coding assignments [10-13, 16, 30]. As fatal pathogenic viruses that can kill ducklings within 72 h, NDRV had caused huge economic losses for the duck industry over the past several decades [31].…”

Section: Discussionmentioning

confidence: 99%

A TaqMan-based real-time PCR assay for specific detection of novel duck reovirus in China

Zhang

Liu

et al. 2020

BMC Vet Res

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Background: In China, Newly emerging duck reovirus (NDRV) variants have been causing major disease problems in cherry valley ducks. NDRV has the potential to cause high morbidity and 5-50% mortality rates. Severe hemorrhagic-necrosis in the liver and spleen were commonly seen in NDRV affected ducks. The availability of upgraded methods for rapid diagnosis of newly emerging DRV variants is crucial for successful DRV infection control and prevention. Results: In this study, we present a TaqMan-based real-time PCR assay (RT-qPCR) for the detection of NDRV infection. Using the conserved regions within the NDRV genome, we designed the specific primers and probe. The lower limit of detection for NDRV infection was 10 copies/μL (Ct values: 38.3) after the optimization of the RT-qPCR conditions. By cross-checking with other duck viral pathogens, no crossreactivity was observed confirming the assay was highly specific for the detection of NDRV. Reproducibility of the RT-qPCR was confirmed by intra-and inter-assay variability was less than 2.91%(Intra-assay variability of Ct values: 0.07-1.48%; Interassay variability of Ct values: 0.49-2.91%). This RT-qPCR and conventional PCR (cPCR) detected one hundred and twenty samples of NDRV infection from different regions. The result shows that the positive rates were 94.17 and 84.17% respectively. The detection rate of RT-qPCR rapid detection assay was 10% higher than that of the cPCR method. Conclusion: This research developed a highly sensitive, specific, reproducible and versatile of RT-qPCR for quantitatively detecting NDRV. It can be used to study the pathogenesis and epidemiology investigation of NDRV.

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“…Previous studies have shown that the release of these cytokines, such as TNF-α, IL-6, and IL-1β, was induced by LPS during Escherichia coli infection ( 30 , 31 ). Further, when Cherry Valley ducks are infected with certain viruses, such as the novel duck reovirus, duck tembusu virus, and duck plague virus, these factors will be increased ( 32 , 33 ). The regulatory cytokines are also seen as being up-regulated during fungal infections ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Cherry Valley Duck Galectin-2 Plays an Essential Role in Avian Pathogenic Escherichia coli Infection-Induced Innate Immune Response

Li¹,

Weng²,

Lin³

et al. 2020

Front. Vet. Sci.

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Galectins play important roles in the host's innate immunity as pattern recognition receptors. In this study, the coding sequences of galectin-2 were identified from Cherry Valley ducks. Tissue distribution of duck galectin-2 (duGal-2) in healthy ducks and ducks infected with avian pathogenic Escherichia coli (APEC) was studied, respectively. The results showed that duGal-2 expression was higher in the gut, kidney, and liver tissue, and weakly expressed in the lung and brain, in healthy ducks; however, the expression level of duGal-2 was detected as being up-regulated after infection with APEC. In addition, knockdown or overexpression of duGal-2 in DEFs was achieved by small interference RNA (siRNA) transfection and plasmid transduction, respectively. The knockdown of duGal-2 led to a decrease in the expression of some inflammatory cytokines such as IL-1β, IL-6, and IL-8, while the expression levels of anti-inflammatory factor IL-10 were up-regulated. At the same time, the bacterial load of APEC was increased after knockdown of duGal-2 in vitro . However, the opposite results were obtained in the duGal-2 overexpression group. Taken together, duGal-2 plays an important role in the host against APEC infection.

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High-mobility group box 1 protein (HMGB1) from Cherry Valley duck mediates signaling pathways and antiviral activity

Cited by 18 publications

References 42 publications

Innate immune responses to duck Tembusu virus infection

Innate immune responses to duck Tembusu virus infection

A TaqMan-based real-time PCR assay for specific detection of novel duck reovirus in China

Cherry Valley Duck Galectin-2 Plays an Essential Role in Avian Pathogenic Escherichia coli Infection-Induced Innate Immune Response

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