High mobility group box 1 knockdown inhibits EV71 replication and attenuates cell pyroptosis through TLR4/NF‐κB/NLRP3 axis
Yufeng Zhang,
Jing Li,
Huiling Deng
et al.
Abstract:Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD) in children. Nowadays, there are still no effective antiviral drugs for EV71 infection. High mobility group box 1 (HMGB1) is reported to be highly expressed in HFMD patients. However, the role and underlying mechanism of HMGB1 in EV71‐associated HFMD are still unclear. HMGB1 expression was detected using RT‐qPCR and western blot assays. Loss‐ and gain‐function experiments were performed to evaluate the effects of HMGB1 on … Show more
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