“…Certain drugs are reported to inhibit HMGB1, including TNF-alpha inhibitors, corticosteroids, chloroquine, statins, and anticancer drugs cisplatine, daunomycine, methothrexate, which show their action towards humoral, cellular immune response or both. Antiagregant clopidogrel, anticoagulants heparin, thrombomodulin, danaparoid, antithrombin and activated protein C are also demonstrated to inhibit HMGB1 expression, release or activity [2][3][4][5][6][7][8][9][10][11][12][13][14]24]. Though the number of patients in our cohort is limited, we observed a very good response to corticosteroids in patients who have high HMGB1 levels.…”