2014
DOI: 10.1189/jlb.0713412
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High-mobility group box-1 and its role in angiogenesis

Abstract: HMGB1 is an architectural chromatin-binding protein that can be released actively by activated cells or passively by dying cells and can serve as a DAMP molecule to drive the pathogenesis of inflammatory and angiogenic diseases. Through TLR4 and RAGE signaling pathways, HMGB1 could regulate vascular growth in vivo and in vitro through diverse mechanisms, including induction of proangiogenic cytokine release and activation of ECs, macrophages, EPCs, and mesoangioblasts, all of which could contribute to vessel f… Show more

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Cited by 82 publications
(71 citation statements)
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References 150 publications
(230 reference statements)
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“…Importantly, IRF5 occupancy on the CDH5 promoter was enhanced by TLR4 activation. Together with the evidence that TLR4 and its endogenous ligands have been implicated in angiogenesis (27,28), the present data provide a previously unidentified insight into the role of IRF5 in TLR4-mediated angiogenesis and suggest that the TLR4-IRF5 axis potentially regulates vascular features of SSc.…”
Section: Discussionmentioning
confidence: 79%
“…Importantly, IRF5 occupancy on the CDH5 promoter was enhanced by TLR4 activation. Together with the evidence that TLR4 and its endogenous ligands have been implicated in angiogenesis (27,28), the present data provide a previously unidentified insight into the role of IRF5 in TLR4-mediated angiogenesis and suggest that the TLR4-IRF5 axis potentially regulates vascular features of SSc.…”
Section: Discussionmentioning
confidence: 79%
“…Most of these evidences have been raised from the effects of HMGB1 on tumor cells themselves [26,40,41]. However, the effects of HMGB1 on other cellular components of tumor stroma and whether this stimulation may favor tumor-supporting processes have remained mostly elusive.…”
Section: Discussionmentioning
confidence: 98%
“…Two major signalling pathways are involved [26]: (i) MAP kinase signalling, including Erk and JNK, which ultimately lead to the activation of NF-κB, and (ii) the Rho-family small GTPase CDC42/Rac and MMP-2/-9 pathway, which is well known as a regulator of cell remodelling and motility. In several cancer models, it has been reported that HMGB1 is related to the expression of MMP-2/-9 [27][28][29].…”
Section: Discussionmentioning
confidence: 99%