High mobility group box 1 is increased in the sera of psoriatic patients with disease progression

Bergmann, Christoph; Strohbuecker, Lisa; Lotfi, Ramin; Sucker, Antje; Joosten, Irma; Koenen, Hans J. P. M.; Körber, Andreas

doi:10.1111/jdv.13564

Cited by 29 publications

(41 citation statements)

References 35 publications

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“…The present study found higher levels of HMGB1 in the patients than in the controls (p < 0:05). In concordance with our results, Strohbuecker et al and Bergmann et al previously showed that HMGB1 is significantly increased in the serum of patients with psoriasis; they have also suggested that the presence of HMGB1 may impact the composition of chronic inflammation in psoriasis which might have implications for Treg and Th17cells [15,28]. Unlike their study, we have not found any relationship between the severity of disease (PASI) and HMGB1.…”

Section: Discussionsupporting

confidence: 92%

Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris

Borský

Fiala

Andrýs

et al. 2020

Mediators of Inflammation

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Background. Psoriasis vulgaris is a chronic autoimmune disease associated with systemic inflammation. Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic patients. Alarmins, also known as danger signals, are intracellular proteins, which are released to an extracellular space after infection or damage. They are the markers of cell destructive processes. Objective. The aim of the present study was to evaluate the suitability of selected alarmins (HMGB1, IL-33, S100A7, and S100A12) as potential biomarkers of severity of psoriasis and to explore possible relationships between these proteins for the purpose of better understanding their roles in the immunopathology of psoriasis. Methods. The serum levels of selected alarmins were measured in 63 psoriatic patients and 95 control individuals. The levels were assessed by the ELISA technique using commercial kits. The data were statistically processed with MedCalc version 19.0.5. Results. In psoriatic patients, we found significantly increased levels of HMGB1 (p<0.05), IL-33 (p<0.01), S100A7 (p<0.0001), and S100A12 (p<0.0001). In addition, we found a significant relationship between HMGB1 and S100A7 (Spearman’s rho=0.276, p<0.05) in the patients and significant relationship between HMGB1 and IL-33 in the controls (Spearman’s rho=0.416, p<0.05). We did not find any relationship between observed alarmins and the disease severity. Conclusions. The alarmins HMGB1, IL-33, S100A7, and S100A12 were significantly elevated in the serum of patients, which states the hypothesis that they play specific roles in the immunopathology of psoriasis. However, we have not yet found a relationship between observed alarmins and the disease severity. The discovery of the relationship between HMGB1 and S100A7 is a novelty that should be studied in the future to further clarify its role and importance.

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Section: Discussionsupporting

confidence: 92%

Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris

Borský

Fiala

Andrýs

et al. 2020

Mediators of Inflammation

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“…35,36 HMGB1, a signalling mediator, has been studied extensively in many spheres, including arthritis, SLE and myositis. In cutaneous diseases, HMGB1 is implicated in pathogenetic aspects of psoriasis 37 involving keratinocytes or fibroblasts. However, the impact of HMGB1 on melanin synthesis and survival of melanocytes has yet to be established.…”

Section: Discussionmentioning

confidence: 99%

Impact of high-mobility group box 1 on melanocytic survival and its involvement in the pathogenesis of vitiligo

et al. 2017

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“…However, when cells are under exogenous or endogenous stress, HMGB1 can be released into the cytoplasm and subsequently into the extracellular space, and then acts as a damage‐associated molecular pattern molecule to promote the immune response by binding to pattern recognition receptors (PRRs) . It has been reported that HMGB1 is secreted from epidermal keratinocytes in psoriatic lesions, and the serum HMGB1 level is correlated with disease severity, which implies the involvement of HMGB1 in the pathogenesis of psoriasis . Moreover, as cells with innate immune functions, keratinocytes express membrane PRRs .…”

Section: Introductionmentioning

confidence: 99%

“…Blocking the proinflammatory function of the HMGB1-IL-18 axis may be useful for psoriasis treatment in the future.No conflicts of interest were declared. secreted from epidermal keratinocytes in psoriatic lesions, and the serum HMGB1 level is correlated with disease severity, which implies the involvement of HMGB1 in the pathogenesis of psoriasis [11,12].…”

mentioning

confidence: 98%

Proinflammatory effect of high-mobility group protein B1 on keratinocytes: an autocrine mechanism underlying psoriasis development

Zhang

Guo

et al. 2016

J. Pathol.

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Psoriasis is an autoimmune skin disease, in which keratinocytes play a crucial pathogenic role. High-mobility group protein B1 (HMGB1) is an inflammatory factor that can be released from keratinocyte nuclei in psoriatic lesions. We aimed to investigate the proinflammatory effect of HMGB1 on keratinocytes and the contribution of HMGB1 to psoriasis development. Normal human keratinocytes were treated with recombinant human HMGB1, and the production of inflammatory factors and the intermediary signalling pathways were examined. Furthermore, the imiquimod-induced psoriasis-like mouse model was used to investigate the role of HMGB1 in psoriasis development in vivo. A total of 11 inflammatory factors were shown to be upregulated by HMGB1 in keratinocytes, among which interleukin (IL)-18 showed the greatest change. We then found that activation of the nuclear factor-κB signalling pathway and inflammasomes accounted for HMGB1-induced IL-18 expression and secretion. Moreover, HMGB1 and downstream IL-18 contributed to the development of psoriasiform dermatitis in the imiquimod-treated mice. In addition, T-helper 17 immune response in the psoriasis-like mouse model could be inhibited by both HMGB1 and IL-18 blockade. Our findings indicate that HMGB1 secreted from keratinocytes can facilitate the production and secretion of inflammatory factors such as IL-18 in keratinocytes in an autocrine way, thus promoting the development of psoriasis. Blocking the proinflammatory function of the HMGB1-IL-18 axis may be useful for psoriasis treatment in the future. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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High mobility group box 1 is increased in the sera of psoriatic patients with disease progression

Abstract: Our data provide insights into a possible role of HMGB1 for inflammation in PV.

Cited by 29 publications

References 35 publications

Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris

Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris

Impact of high-mobility group box 1 on melanocytic survival and its involvement in the pathogenesis of vitiligo

Proinflammatory effect of high-mobility group protein B1 on keratinocytes: an autocrine mechanism underlying psoriasis development

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