Keywords: InSb quantum well, quantum point contact, g-factor anisotropy, electron effective mass, conductance quantization 2 Due to a strong spin-orbit interaction and a large Landé g-factor, InSb plays an important role in research on Majorana fermions. To further explore novel properties of Majorana fermions, hybrid devices based on quantum wells are conceived as an alternative approach to nanowires. In this work, we report a pronounced conductance quantization of quantum point contact devices in InSb/InAlSb quantum wells. Using a rotating magnetic field, we observe a large in-plane( 1 26 g ) and out-of-plane ( 1 52 g ) g-factor anisotropy. Additionally, we investigate crossings of subbands with opposite spins and extract the electron effective mass from magnetic depopulation of one-dimensional subbands.Among the binary III-V semiconductors, InSb has the smallest effective mass and the highest room temperature mobility 1 . It further exhibits a strong spin-orbit interaction (SOI) and the largest Landé g-factor ( 51 g for the bulk), due to the strong coupling between the conduction band and the valence band resulting from the small energy gap [1][2][3] . Besides the continuously increasing interest in its various applications in spintronics 4 , InSb has been extensively investigated for Majorana fermions and topological quantum computing (TQC) 5,6 . Applying a magnetic field perpendicular to the spin-orbit field of a nanowire opens a Zeeman energy gap wells are yet to be established. In this work, we demonstrate ballistic transport through QPCs in an InSb 2DEG. In a rotating magnetic field, the Zeeman spin splitting is investigated and a large 4 in-plane and out-of-plane g-factor anisotropy is observed. Furthermore, crossings of subbands with opposite spins are studied and the electron effective mass is deduced using magnetic depopulation 34,35 .The InSb/InAlSb heterostructure used in this work is grown on a GaAs (100) By a comparison of the two types of QPCs, we find that the etch-defined QPC shows pronounced quantized conductance plateaus at zero magnetic field, while the fully gate-defined type requires a small perpendicular magnetic field to suppress backscattering and interference.Therefore, we focus on the former in the following and briefly present the results on the latter in the Supporting Information Fig. S1. At large Bz > 1 T (out-of-plane), as shown in Fig. 3a, in contrast to the case of Bx, all plateaus widen due to Zeeman splitting and magnetic depopulation of 1D subbands, as will be discussed below. For the case of By (in-plane but perpendicular to current flow), as displayed in Fig. 3b, the behavior is similar to that in Bx, although here the measured magnetic field range is smaller.To directly inspect the evolution of the spin splitting in a magnetic field along different orientations, the magnetic field is rotated in the x-z plane (Fig. 3c) and the x-y plane (Fig. 3d) 7 while keeping the amplitude fixed at 1.8 T and 1 T, respectively. The magnetoresistance from the adjacent InSb 2DEG i...