High microRNA-28-5p expression in colorectal adenocarcinoma predicts short-term relapse of node-negative patients and poor overall survival of patients with non-metastatic disease

Tsiakanikas, Panagiotis; Kontos, Christos K.; Kerimis, Dimitrios; Papadopoulos, Iordanis N.; Scorilas, Andreas

doi:10.1515/cclm-2017-0430

Cited by 28 publications

(25 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prognostic and predictive value improves by the synergy of more than two miRNAs, encouraging the development of multipurpose miRNA signatures as diagnostic or prognostic tools (46)(47)(48). For instance, combination of miR-15a-5p, miR-16, miR-24-3p, miR-28-5p, miR-34a, miR-96, miR-182, and miR-224, which have been proposed as molecular biomarkers with significant prognostic value in colorectal cancer (CRC); has already been proposed as a prognostic signature in this malignancy (49)(50)(51)(52)(53)(54)(55)(56)(57); another very important miRNA that could be added in this molecular signature is miR-21, a predictor of metastatic tumor potential in this cancer (58). Similar signatures consisting of miRNAs have been proposed in prostate cancer (59,60), laryngeal squamous cell carcinoma (61), and other human malignancies (62).…”

Section: Introductionmentioning

confidence: 99%

Non-coding RNAs: the riddle of the transcriptome and their perspectives in cancer

Diamantopoulos¹,

Tsiakanikas²,

Scorilas³

2018

Ann. Transl. Med.

Self Cite

100

View full text Add to dashboard Cite

Non-coding RNAs (ncRNAs) constitute a heterogeneous group of RNA molecules in terms of biogenesis, biological function as well as length and structure. These biological molecules have gained attention recently as a potentially crucial layer of tumor cell progression or regulation. ncRNAs are expressed in a broad spectrum of tumors, and they play an important role not only in maintaining but also in promoting cancer development and progression. Recent discoveries have revealed that ncRNAs may act as key signal transduction mediators in tumor signaling pathways by interacting with RNA or proteins. These results reinforce the hypothesis, that ncRNAs constitute therapeutic targets, and point out their clinical potential as stratification markers. The major purpose of this review is to mention the emergence of the importance of ncRNAs, as molecules which are correlated with cancer, and to discuss their clinical implicit as prognostic diagnostic indicators, biomarkers, and therapeutic targets.

show abstract

Section: Introductionmentioning

confidence: 99%

Non-coding RNAs: the riddle of the transcriptome and their perspectives in cancer

Diamantopoulos¹,

Tsiakanikas²,

Scorilas³

2018

Ann. Transl. Med.

Self Cite

100

View full text Add to dashboard Cite

show abstract

“…Among the evaluated studies, 49 demonstrated the downregulation of miR-199b 47, 48 , miR-6852 106 , miR-302c 67 , miR-466 68 , miR-650 123 , miR-196b-5p 70 , miR-944 71 , miR-30d 72 , miR-296 73 , miR-187 124 , let-7a-5p 98 , miR-132 99 , miR-206 100 , miR-148a 125 , miR-33b 76 , miR-99b-5p 120 , miR-154 78 , miR-217 126 , miR-149 79 , miR-194 80 , miR-7 56 , miR-24-3p 54 , miR-29b 127 , miR-15a 34 , miR-16 34, 36 , miR-204-5p 128 , miR-96-5p 121 , miR-193a-5p 108 , miR-100 81 , miR-133a 41 , miR-139-5p 129 , miR-124-5p 130 , miR-335 82 , miR-378 101 , miR-126 40 , miR-378a-3p 58 , miR-378a-5p 58 , miR-218 83 , miR-138 110 , miR-625 111 , miR-212 112 , miR-124 131 , miR-22 49 , miR-133b 39 , miR-193a-3p 104 , miR-195 113 and miR-30c 103 associated with worse prognosis (lower overall survival) of CRC patients. Fifty-six studies identified the upregulation of miR-181a 31–33 , miR-182 43, 44 , miR-1296 84 , miR-888 64 , miR-28-5p 132 , miR-183 45, 46 , miR-200c 114 , miR-34a 133 , miR-15a-5p 134 , miR-181c 135 , miR-24-3p 53 , miR-16 35 , miR-7 55 , miR-96 86 , miR-1260b 115 , miR-20a-5p 63 , miR-517a 87 , miR-503 136 , miR-106b 88 , miR-211 137 , miR-320e 89 , miR-592 90 , miR-196a 57 , miR-196b 57 , miR-376a …”

Section: Resultsmentioning

confidence: 99%

“…In total, 17 studies demonstrated the downregulation of 18 miRs associated with worse disease free-survival such as miR-196b-5p 70 , miR-944 71 , miR-30d 72 , miR-22 50 , miR-296 73 , miR-199b 47 , miR-187 124 , let-7a-5p 98 , miR-132 99 , miR-29b 127 , miR-15a 34 , miR-16 34 , miR-34a-5p 65 , miR-193a-5p 108 , miR-138 110 , miR-126 8 , miR-212 112 and miR-124 131 . Twenty-one studies associated the upregulation of miR-888 64 , miR-28-5p 132 , miR-183 45 , miR-200c 114 , miR-34a 133 , miR-15a-5p 134 , miR-181c 135 , miR-24-3p 53 , miR-16 35 , miR-96 86 , miR-1260b 115 , miR-20a-5p 63 , miR-517a 87 , miR-503 136 , miR-106b 88 , miR-320e 89 , miR-196a 57 , miR-196b 57 , miR-224 51 , miR-494 61 , miR-181a 32 , miR-21 25, 26, 30 and miR-155 30 with worse disease free-survival.…”

Section: Resultsmentioning

confidence: 99%

Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review

Santos

Penna

Carneiro

et al. 2019

Preprint

View full text Add to dashboard Cite

Colorectal cancer (CRC) is a multifactorial disease commonly diagnosed worldwide, with high mortality rates. Several studies demonstrate important associations between differential expression of micro-RNAs (miRs) and the prognosis of CRC. However, only a few systematic reviews emphasize the most relevant miRs able to contribute to the establishment of new prognostic biomarkers in CRC patients. The present study aimed to identify differentially expressed tissue miRs associated with prognostic factors in CRC patients, through a systematic review of the Literature. Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. All the included studies used RT-PCR (Taqman or SYBR Green) for miR expression analysis and the period of publication was from 2009 to 2018. A total of 115 articles accomplished the inclusion criteria and were included in the review. The studies investigated the expression of 102 different miRs associated with prognostic aspects in colorectal cancer patients. The most frequent oncogenic miRs investigated were miR-21, miR-181a, miR-182, miR-183, miR-210 and miR-224 and the hyperexpression of these miRs was associated with distant metastasis, lymph node metastasis and worse survival in patients with CRC. The most frequent tumor suppressor miRs were miR-126, miR-199b and miR-22 and the hypoexpression of these miRs was associated with distant metastasis, worse prognosis and a higher risk of disease relapse (worse disease-free survival). Specific tissue miRs are shown to be promising prognostic biomarkers in patients with CRC, given their strong association with the prognostic aspects of these tumors, however, new studies are necessary to establish the sensibility and specificity of the miRs in order to use them in clinical practice.

show abstract

“…miR-28 was shown to regulate T-cell exhaustion via controlling the expression of inhibitory receptors such as PD-1 and T-cell immunoglobulin domain and mucin domain 3. Furthermore, the upregulation of miR-28-5p was linked to poor overall survival and shorter disease-free periods in patients with CRC, independent from the clinicopathological features of the tumor or the therapeutic protocol [60]. Furthermore, the upregulation of miR-28-5p was linked to poor overall survival and shorter disease-free periods in patients with CRC, independent from the clinicopathological features of the tumor or the therapeutic protocol [60].…”

Section: Mirnas Regulation Of Pd-1 Checkpoint Proteinmentioning

confidence: 94%

“…The inhibition of miR-28 led to the upregulated expression of such inhibitory receptors [59]. Furthermore, the upregulation of miR-28-5p was linked to poor overall survival and shorter disease-free periods in patients with CRC, independent from the clinicopathological features of the tumor or the therapeutic protocol [60]. Wei et al [61] have indicated that miR-138 targets the 3 0 UTRs of PD-1 and CTLA-4, inhibiting their expression.…”

Section: Mirnas Regulation Of Pd-1 Checkpoint Proteinmentioning

confidence: 99%

Immunomodulatory MicroRNAs in cancer: targeting immune checkpoints and the tumor microenvironment

et al. 2019

View full text Add to dashboard Cite

Cancer immunotherapy represents a promising new era in cancer management due to the relatively high safety margins and selectivity, compared to the classical cancer chemotherapeutic agents. However, there is an imperative need to overcome tumor resistance in order to improve clinical outcomes and maximize the benefits of cancer immunotherapy. The interaction between the programmed cell death‐1 (PD‐1) receptor and its ligand PD‐L1 is a vital immune checkpoint that is often adopted by cancer cells to undergo immune evasion. PD‐1/PD‐L1 signaling is regulated at multiple levels through the crosstalk with other immune targets or relevant signaling partners involved in the cancer progression. Among the significant epigenetic players that are implicated in modulating the immune system are microRNAs (miRNAs). A complex system of these noncoding RNAs regulates the gene expression at the post‐transcriptional level and plays a significant role in the modulation of both innate and the adaptive immune systems. The expression profile of immune‐modulatory miRNAs might be useful as a predictive biomarker for the response and clinical outcomes in cancer immunotherapy. Therefore, in the current review, we highlighted the role of miRNAs in cancer immune evasion through a critical discussion of their impact on key immune checkpoints as well as the role of miRNAs in cancer progression and resistance.

show abstract

High microRNA-28-5p expression in colorectal adenocarcinoma predicts short-term relapse of node-negative patients and poor overall survival of patients with non-metastatic disease

Abstract: High miR-28-5p expression predicts poor DFS and OS of colorectal adenocarcinoma patients, independently of clinicopathological prognosticators and standard patient treatment, including radiotherapy and chemotherapy.

Cited by 28 publications

References 48 publications

Non-coding RNAs: the riddle of the transcriptome and their perspectives in cancer

Non-coding RNAs: the riddle of the transcriptome and their perspectives in cancer

Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review

Immunomodulatory MicroRNAs in cancer: targeting immune checkpoints and the tumor microenvironment

Contact Info

Product

Resources

About