High manganese exposure decreased the risk of high triglycerides in workers: a cross-sectional study

Abstract

Background: Manganese (Mn) participates in lipid metabolism. However, the associations between Mn exposure and dyslipidaemia is unclear. Methods: This was a cross-sectional study. Data were collected from the 2017 the Mn-exposed workers healthy cohort (MEWHC). Finally, 803 occupationally Mn-exposed workers included in the study. The workers were divided into two groups. The grouping of this study was based on Mn-Time Weighted Averages (Mn-TWA). The highexposure group included participants with Mn-TWA greater than 0.15 mg/m 3 . The low-exposure group included participants with Mn-TWA less than or equal to 0.15 mg/m 3 . Mn-TWA levels and dyslipidaemia were assessed. Results: After adjustment for seniority, sex, cigarette consumption, alcohol consumption, high-fat diet frequency, medicine intake in the past two weeks, egg intake frequency, drinking tea, WHR, and hypertension, Mn-TWA levels was negatively correlated with high triglycerides (TG) risk in workers overall (OR = 0.51; 95% CI: 0.36, 0.73; p < 0.01). The results of males and females were consistent (OR = 0.53; 95% CI: 0.34, 0.81; p < 0.01) and (OR = 0.47; 95% CI: 0.24, 0.94; p < 0.01), respectively. By performing interactions analyses of workers overall, we observed no significant interactions among confounders. Mn-TWA levels and pack-years on high TG risk (relative excess risk for the interactions (RERI = 2.29, 95% CI: − 2.07, 6.66), (RERI) = 2.98, 95% CI: − 2.30, 8.26). Similarly, smoking status, drinking status, high-fat diet frequency, and Waist-to-Hip Ratio (WHR) showed non-significant interactions with Mn-TWA levels on high TG risk. Conclusions: This research indicates that high Mn exposure was negatively related to high TG risk in workers.

Association between serum manganese levels and diabetes in Chinese adults with hypertension

“…8 Besides, Mn is strongly associated with risks of many NCDs including cardiovascular disease, dyslipidemia, chronic kidney disease and diabetes. [8][9][10][11][12] However, as a potential toxicant, overexposure to manganese can also be dangerous because of its neurotoxicity, reproductive toxicity, and cardiovascular toxicity. 13,14 Additionally, excessive manganese can result in higher oxidative stress and inflammation levels by disrupting the antioxidative activity of MnSOD and promoting the production of ROS.…”

“…Not only does manganese play an important role in many biological functions, 7 but also the key component of manganese‐dependent enzymes in the body 8 . Besides, Mn is strongly associated with risks of many NCDs including cardiovascular disease, dyslipidemia, chronic kidney disease and diabetes 8–12 . However, as a potential toxicant, overexposure to manganese can also be dangerous because of its neurotoxicity, reproductive toxicity, and cardiovascular toxicity 13,14 .…”

Sirt3-Sod2-mROS-Mediated Manganese Triggered Hepatic Mitochondrial Dysfunction and Lipotoxicity in a Freshwater Teleost

“…The quantification of cytoplasmic vacuolations and lipid droplets in the H&E and ORO staining further confirmed these observations (Figure H,I). Similarly, Luo et al pointed out that higher Mn intake increased the liver TG content …”

“…In vertebrates, the liver is a central metabolic organ that responds to adverse environmental conditions by changing lipid metabolism. , Lipid metabolism has been extensively used as new biomarkers for monitoring and assessing the risk of toxic pollutants in the aquatic environment. , Lipotoxicity refers to the state in which lipids were accumulated in tissues and cells and cannot adequately be metabolized . Growing evidence suggests that hepatic lipotoxicity is highly dependent on toxicants and diet style. ,, Among these factors, Mn affects lipid metabolism in humans and fish. , Mn-induced liver injury could contribute to lipotoxicity by accelerating the progression of hepatic lipid accumulation. Importantly, heat stress proteins (HSPs) are involved in oxidative stress-mediated liver damage in excess Mn-treated chicken and fish, but the regulatory mechanisms of HSPs on lipotoxicity remain unclear.…”

Recent advances in the application of ionomics in metabolic diseases

“…On the other hand, several studies have either confirmed previous observations or revealed additional elements that are associated with hyperlipidemia. For example, high Mn exposure could decrease the risk of high triglycerides ( 225 ), while elevated blood/serum levels of toxic heavy metals (such as Hg, As, and Pb) may increase the risk of different types of hyperlipidemia ( 226 – 228 ). Very recently, Barragán et al examined the associations of plasma essential trace elements with hyperlipidemia in a Mediterranean population, which demonstrated that plasma Mg concentrations and combined effect of plasma Zn, Cu, and Se levels had a positive association with hypercholesterolemia whereas plasma Mn concentrations would have negative effects on the amount of plasma lipids ( 229 , 230 ).…”