High &lt;i&gt;Toxoplasma gondii&lt;/i&gt; Seropositivity among Brain Tumor Patients in Korea

Jung, Byung Mun; Song, Hyemi; Kim, Min Jae; Cho, Jaeeun; Shin, Eun Hee; Chai, Jong Yil

doi:10.3347/kjp.2016.54.2.201

Cited by 20 publications

(18 citation statements)

References 22 publications

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“…ELISA was used for detection of anti-T. gondii IgG and IgM antibodies in tumor patients and approved the association between T. gondii infection and nasopharyngeal carcinoma [6]. Jung et al revealed 18.3% T. gondii seropositivity among brain tumor patients in Korea (p < 0.05) using ELISA [18]. Conversely, Wang et al reported a positive rate of 8.38% in cancer patients for toxoplasmosis [15].…”

Section: Discussionmentioning

confidence: 99%

The relationship between toxoplasmosis and different types of human tumors

Mostafa

Hamed

Rashed

et al. 2018

J Infect Dev Ctries

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Introduction: Toxoplasma gondii is an intracellular protozoan that may disrupt the traditional cell barriers against cancer, allowing the accumulation of oncogenic mutations over time. Our research aimed to explore the relationship between T. gondii infection and tumor development. Methodology: The anti-T. gondii IgG and IgM antibodies were tested for156 patients with tumors (51 with breast cancer, 20 with hepatoma, 20 with larynx carcinoma, 20 with squamous cell carcinoma of bone, 16 with lymphoma, 13 with brain tumor, 4 with bladder cancer and 12 with benign uterine tumor) and 90 healthy controls by using electrochemiluminescence immunoassay. Tissue specimens were collected from T. gondii seropositive cases for histological and immunohistochemistry (IHC) examinations. Results: The seroprevalence of human toxoplasmosis in the Sharkia Governorate, Egypt is significantly correlated with various types of tumors: breast cancer in 49 subjects (96.1%), and squamous cell carcinoma of bone in 16 subjects (80%). It was also present in nine cases of brain tumors. Anti-Toxoplasma IgG was detected in seven cases of liver tumors and one-quarter of bladder cancer. The anti- Toxoplasma IgM was present in three patients with benign uterine tumors, one patient with a bone tumor and two patients with breast cancer. Toxoplasma cysts were detected in immunostained brain sections. Conclusion: The correlation between T. gondii infection and tumors was established by this study indicating a significant emerging role of human toxoplasmosis in the etiology or existence of particular types of tumors.

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Section: Discussionmentioning

confidence: 99%

The relationship between toxoplasmosis and different types of human tumors

Mostafa

Hamed

Rashed

et al. 2018

J Infect Dev Ctries

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“…Cancer patients who are seronegative for T. gondii infection could benefit from advice on precautionary measures, to avoid seroconversion that may induce active severe toxoplasmosis [15]. Therefore, potential associations between T. gondii infection and cancer have attracted a lot of attention [3,4,[16][17][18][19][20][21][22][23][24][25][26]. Oral cancer is one of the most common malignant tumours.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study

Zhou

Zhang

et al. 2018

Epidemiol. Infect.

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Over the recent years, potential associations between Toxoplasma gondii (T. gondii) infection and cancer risk have attracted a lot of attention. Nevertheless, the association between T. gondii infection and oral cancer remains relatively unexplored. We performed a case-control study of 861 oral cancer patients and 861 control subjects from eastern China with the aim to detect antibodies to T. gondii by enzyme-linked immunosorbent assay (ELISA) in these patients. The results showed that oral cancer patients (21.72%, 187/861) had a significantly higher seroprevalence than control subjects (8.25%, 71/861) (P < 0.001). Among them, 144 (16.72%) oral cancer patients and 71 (8.25%) control subjects were positive for IgG antibodies to T. gondii, while 54 (6.27%) oral cancer patients and 9 (1.05%) controls were positive for IgM antibodies to T. gondii. In addition, multiple logistic analysis showed that T. gondii infection in oral cancer patients was associated with blood transfusion history, keeping cats at home, and oyster consumption. To our knowledge, this is the first study that provided a serological evidence of an association between T. gondii infection and oral cancer patients. However, further studies are necessary to elucidate the role of T. gondii in oral cancer patients.

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“…Based on current knowledge, the anti-tumour effects observed are attributable to modifications to the host immune response, and thus their characteristics and locations within the host can be highly diverse. It must also be emphasized that, similarly to Plasmodium, T. gondii and E. granulosus, which exhibits certain antitumours effects, may also promote tumour development (Chookami et al 2015;Turhan et al 2015;Daneshpour et al 2016;Jung et al 2016).…”

Section: Types Of Cancer In Which Eukaryotic Parasites Potentially Exmentioning

confidence: 99%

Puzzling and ambivalent roles of malarial infections in cancer development and progression

Faure

2016

Parasitology

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Scientific evidence strongly suggests that parasites are directly or indirectly associated with carcinogenesis in humans. However, studies have also indicated that parasites or their products might confer resistance to tumour growth. Plasmodium protozoa, the causative agents of malaria, exemplify the ambivalent link between parasites and cancer. Positive relationships between malaria and virus-associated cancers are relatively well-documented; for example, malaria can reactivate the Epstein-Barr Virus, which is the known cause of endemic Burkitt lymphoma. Nevertheless, possible anti-tumour properties of malaria have also been reported and, interestingly, this disease has long been thought to be beneficial to patients suffering from cancers. Current knowledge of the potential pro- and anti-cancer roles of malaria suggests that, contrary to other eukaryotic parasites affecting humans, Plasmodium-related cancers are principally lymphoproliferative disorders and attributable to virus reactivation, whereas, similar to other eukaryotic parasites, the anti-tumour effects of malaria are primarily associated with carcinomas and certain sarcomas. Moreover, malarial infection significantly suppresses murine cancer growth by inducing both innate and specific adaptive anti-tumour responses. This review aims to present an update regarding the ambivalent association between malaria and cancer, and further studies may open future pathways to develop novel strategies for anti-cancer therapies.

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High <i>Toxoplasma gondii</i> Seropositivity among Brain Tumor Patients in Korea

Cited by 20 publications

References 22 publications

The relationship between toxoplasmosis and different types of human tumors

The relationship between toxoplasmosis and different types of human tumors

Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study

Puzzling and ambivalent roles of malarial infections in cancer development and progression

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