2019
DOI: 10.1177/0271678x19874770
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High long-term test–retest reliability for extrastriatal 11C-raclopride binding in healthy older adults

Abstract: In vivo dopamine D2-receptor availability is frequently assessed with 11C-raclopride and positron emission tomography. Due to low signal-to-noise ratios for 11C-raclopride in areas with low D2 receptor densities, the ligand has been considered unreliable for measurements outside the dopamine-dense striatum. Intriguingly, recent studies show that extrastriatal 11C-raclopride binding potential (BPND) values are (i) reliably higher than in the cerebellum (where D2-receptor levels are negligible), (ii) correlate w… Show more

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Cited by 17 publications
(14 citation statements)
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“…However, these studies have rarely included the amygdala or applied single scan bolus/infusion paradigms which arguably adds to the sensitivity of the measure. Moreover, test-retest reliability of amygdala [ 11 C]raclopride BP has been reported to be high (21). Also, here we found similar changes in [ 11 C]raclopride BP ND in the amygdala and the striatum, although amygdala release had higher variability, whereas our control region, the frontal cortex did not indicate dopamine release.…”
Section: Discussionsupporting
confidence: 82%
See 1 more Smart Citation
“…However, these studies have rarely included the amygdala or applied single scan bolus/infusion paradigms which arguably adds to the sensitivity of the measure. Moreover, test-retest reliability of amygdala [ 11 C]raclopride BP has been reported to be high (21). Also, here we found similar changes in [ 11 C]raclopride BP ND in the amygdala and the striatum, although amygdala release had higher variability, whereas our control region, the frontal cortex did not indicate dopamine release.…”
Section: Discussionsupporting
confidence: 82%
“…1). We used single scan bolus/infusion of [ 11 C]raclopride (20,21) to measure conditioning-related change in binding potential (i.e., dopamine release) (15), combined with functional magnetic resonance imaging (fMRI) to measure neural activity. We predicted that increased dopamine levels in the amygdala during fear conditioning would facilitate learning (8,13,14), with greater dopamine release related to superior cue discrimination and enhanced amygdala-located fear engram formation.…”
mentioning
confidence: 99%
“…Finally, we repeated the k ‐means clustering but instead of the [ 11 C]raclopride‐PET template, we used estimates of D 2/3 R availability obtained from a [ 18 F]fallypride‐PET template (Castrellon et al, 2019). This was done to ensure that the segmentation results are not affected by differences in presentation of striatal and extra‐striatal D 2/3 R availability with these two radiotracers (Karalija et al, 2020; Svensson et al, 2019).…”
Section: Methodsmentioning
confidence: 99%
“…where B is the quantity of bound ligand. The binding potential is defined as the ratio of the volumes of distribution of specifically bound ("displaceable") and non-specifically bound ("nondisplaceable") ligand quantities (14,15). To determine the binding potential of a radioligand, the volumes of distribution are entered into the relationship that defines the binding potential (2,5,16):…”
Section: Methodsmentioning
confidence: 99%