High levels, partitioning and fish consumption based water guidelines of perfluoroalkyl acids downstream of a former firefighting training facility in Canada

Bhavsar, Satyendra P.; Fowler, Craig; Day, Sarah; Petro, Steve; Gandhi, Nilima; Gewurtz, Sarah B.; Hao, Chunyan; Zhao, Xiaoming; Drouillard, Ken G.; Morse, David G.

doi:10.1016/j.envint.2016.05.023

Cited by 26 publications

(11 citation statements)

References 22 publications

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“…PFASs are a family of fluorine‐containing chemicals that have unique hydrophobic and lipophobic properties. Owing to the chemical uniqueness of PFASs, these compounds have been integrated into a wide array of consumer and industrial products dating back to the 1950s (Bhavsar et al., ; Lau et al., ). PFASs and their derivatives are persistent chemicals that do not breakdown easily.…”

Section: Food Safety Issues With Recreational Fishing For Foodmentioning

confidence: 99%

The nexus of fun and nutrition: Recreational fishing is also about food

et al. 2017

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Recreational fishing is a popular activity in aquatic ecosystems around the globe using a variety of gears including rod and line and to a lesser extent handlines, spears, bow and arrow, traps and nets. Similar to the propensity to engage in voluntary catch‐and‐release, the propensity to harvest fishes strongly varies among cultures, locations, species and fisheries. There is a misconception that because recreational fishing happens during non‐work (i.e. leisure) time, the nutritional motivation is negligible; therefore, the role of recreational fishing in supporting nutrition (and thus food security) at regional, national or global scales is underappreciated. We consider the factors that influence whether fish will be harvested or released by examining the motives that underlie recreational fishing. Next, we provide an overview of the magnitude and role of recreational fishing harvest in supporting nutrition using regional case‐studies. Then, we address issues such as contaminants and parasites that constrain the ability of fish harvested by recreational fishers to be consumed. Although recreational fishing is foremost a leisure activity, the harvest of fish for personal consumption by recreational fishers has contributed and will continue to contribute to human nutrition by providing an accessible, affordable and generally highly sustainable food source, notwithstanding concerns about food safety and possibly overfishing. Attempts to better quantify the role of fish harvested by recreational fishers and the relative contribution to overall food security and personal nutrition will provide resource managers and policymakers the information needed to guide management activities and policy development.

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Section: Food Safety Issues With Recreational Fishing For Foodmentioning

confidence: 99%

The nexus of fun and nutrition: Recreational fishing is also about food

et al. 2017

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“…However, due to their chemical and thermal stability, PFOS can exist in the environment for a long time, and is highly resistant to microbial degradation [2]. Recent reports showed that concentrations of PFOS in fish reached the level of 15,000 ng/g [3]. PFOS, which is considered to be a new kind of persistent organic pollutant, has the potential adverse effect on the reproductive system, liver, heart, and lung [4].…”

Section: Introductionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor Mediated Perfluorooctane Sulfonate Induced-Neurotoxicity via Epigenetics Regulation in SK-N-SH Cells

Guo

et al. 2017

IJMS

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Perfluorooctane sulfonate (PFOS), a new kind of persistent organic pollutant, is widely distributed in the environment and exists in various organisms, where it is also a neurotoxic compound. However, the potential mechanism of its neurotoxicity is still unclear. To examine the role of epigenetics in the neurotoxicity induced by PFOS, SK-N-SH cells were treated with different concentrations of PFOS or control medium (0.1% DMSO) for 48 h. The mRNA levels of DNA methyltransferases (DNMTs) and Brain-derived neurotrophic factor (BDNF), microRNA-16, microRNA-22, and microRNA-30a-5p were detected by Quantitative PCR (QPCR). Enzyme Linked Immunosorbent Assay (ELISA) was used to measure the protein levels of BDNF, and a western blot was applied to analyze the protein levels of DNMTs. Bisulfite sequencing PCR (BSP) was used to detect the methylation status of the BDNF promoter I and IV. Results of MTT assays indicated that treatment with PFOS could lead to a significant decrease of cell viability, and the treated cells became shrunk. In addition, PFOS exposure decreased the expression of BDNF at mRNA and protein levels, increased the expression of microRNA-16, microRNA-22, microRNA-30a-5p, and decreased the expression of DNMT1 at mRNA and protein levels, but increased the expression of DNMT3b at mRNA and protein levels. Our results also demonstrate that PFOS exposure changes the methylation status of BDNF promoter I and IV. The findings of the present study suggest that methylation regulation of BDNF gene promoter and increases of BDNF-related-microRNA might underlie the mechanisms of PFOS-induced neurotoxicity.

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“…PFHxS has an exemption half-life time, which is longer than PFOS, however, a linear relationship between bioaccumulation factor (BAF) of PFSAs and carbon number was reported. The BAF value of PFHxS was lower than that of PFOS (Kwadijk, Korytár, and Koelmans 2010;Bhavsar et al 2016). In addition, BAF value was also both related to the exposure concentrations of PFAAs, and its relationship with length of the carbon chains has also been proved by experiment (Liu et al 2011).…”

Section: Bioaccumulation and Biological Magnificationmentioning

confidence: 79%

A review on perfluoroalkyl acids studies: Environmental behaviors, toxic effects, and ecological and health risks

Liu

et al. 2019

Ecosyst Health Sustain

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Perfluoroalkyl acids (PFAAs) are emerging persistent organic pollutants that are globally distributed in the environment. In the present review, the occurrence of PFAAs and their behavior in aquatic ecosystem were summarized, and the health and ecological risk assessment and the multimedia fate simulation were investigated. PFAAs are most likely to exist in the aqueous phase, and PFAAs in atmosphere are also able to enter water bodies through diffusion and wet and dry deposition and eventually become widely distributed in various environmental media. The air-solid partition is considered to be one of the major factors in the long-distance transportation of the pollutants. The pKa values and organic carbon fraction of the sediment could influence the partition of PFAAs between water and sediment. Otherwise, PFAAs have teratogenic, mutagenic and other toxic effects and they could be accumulated by biota, and magnified through trophic level. The ecological and health risks of PFOA and PFOS were assessment. In order to explore the partition mechanism and reduce the uncertainty of the simulation of the transport, transformation and fate, the experimental methods on physicochemical properties of PFAAs should be developed. Moreover, further studies on toxicities of PFAAs are necessary for health and ecological risk assessment.

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High levels, partitioning and fish consumption based water guidelines of perfluoroalkyl acids downstream of a former firefighting training facility in Canada

Cited by 26 publications

References 22 publications

The nexus of fun and nutrition: Recreational fishing is also about food

The nexus of fun and nutrition: Recreational fishing is also about food

Brain-Derived Neurotrophic Factor Mediated Perfluorooctane Sulfonate Induced-Neurotoxicity via Epigenetics Regulation in SK-N-SH Cells

A review on perfluoroalkyl acids studies: Environmental behaviors, toxic effects, and ecological and health risks

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