High levels of vitamin D in relation to reduced risk of schizophrenia with elevated C-reactive protein

Zhu, Daomin; Liu, Yong; Zhang, Aiguo; Chu, Zhao-xue; Wu, Qing; Li, Hui; Ge, Jin‐Fang; Dong, Yi; Zhu, Peng

doi:10.1016/j.psychres.2015.05.051

Cited by 31 publications

(18 citation statements)

References 33 publications

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“…[7][8][9] A systematic review conducted in 2013 showed an overview of Vitamin D status globally and revealed that vitamin D deficiency is significantly present all over the world in all age groups, despite countries that have sun exposure all year-round including Hawaii, India, Turkey, Saudi Arabia and Iran. [9][10][11][12][13][14] There is a significant presence of Vitamin D deficiency in the Middle East, especially among females. 6 A qualitative study performed in UK reported limited knowledge about the health benefits of vitamin D and confusion about both the risks and benefits of sun exposure and vitamin D food sources.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Awareness, Knowledge, Attitude, and the Practice of Vitamin D among the General Public in Malaysia

Blebil

Dujaili

Teoh

et al. 2019

J. Karnali Acad. Health Sci.

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Background: Vitamin D deficiency is becoming a global epidemic, which is still undertreated despite increased treatment availability and increase in therapeutic options. This study aimed to explore the awareness, knowledge, attitude and practices regarding Vitamin D among the general public in Malaysia. Methods: A cross-sectional survey was carried out in a public area using a convenience samplingtechnique to recruit participants around Selangor and Kuala Lumpur shopping malls area. An anonymous self-administeredquestionnaire was used for data collection and it was circulated to 603 Malaysian. A total of 400 participants were completed and returned to the researchers. Result: Although 90.5% of the participants have heard/learnt about Vitamin D. About 78.0% of them showed limited knowledge about some aspects of Vitamin D with (mean ± SD = 1.78 ± 0.894). Additionally, there was a negative attitude towards Vitamin D and sunlight exposure. For instance, nearly 70.0% of the respondents did not like to expose themselves to sunlight. Only 30.0% of the participants had taken Vitamin D supplement before.There is a small, positive correlation between the knowledge score and education level, rho = 0.124, n = 400, P = 0.013, with a higher score associated with higher education level. Conclusion: The findings provided a piece of contemporary real-world evidenceon the lack of knowledge and practices about Vitamin D among the general public. Therefore, extensive health educational campaigns for the public should be implemented by the government to raise their knowledge on the importance of Vitamin D.

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Section: Introductionmentioning

confidence: 99%

Assessment of Awareness, Knowledge, Attitude, and the Practice of Vitamin D among the General Public in Malaysia

Blebil

Dujaili

Teoh

et al. 2019

J. Karnali Acad. Health Sci.

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“…Indeed, two cross-sectional studies have reported that vitamin-D is inversely associated with levels of C-reactive protein, a marker of inflammation, in psychosis (96, 104). …”

Section: Vitamin-d Studies In Schizophrenia Patientsmentioning

confidence: 99%

Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis, Schizophrenia, and Autism

et al. 2017

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In this short review, we want to summarize the current findings on the role of vitamin-D in multiple sclerosis (MS), schizophrenia, and autism. Many studies have highlighted hypovitaminosis-D as a potential environmental risk factor for a variety of conditions such as MS, asthma, cardiovascular disease, and, more recently, psychiatric diseases. However, whether hypovitaminosis-D is a potential causative factor for the development or activity in these conditions or whether hypovitaminosis-D may be due to increased vitamin-D consumption by an activated immune system (reverse causation) is the focus of intense research. Here, we will discuss current evidence exploring the role of vitamin-D in MS, schizophrenia, and autism and its impact on adaptive and innate immunity, antimicrobial defense, the microbiome, neuroinflammation, behavior, and neurogenesis. More work is needed to gain insight into its role in the underlying pathophysiology of these conditions as it may offer attractive means of intervention and prevention.

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“…Preliminary findings have suggested that vitamin D supplementation may improve cognition in schizophrenia , however the association of hypovitaminosis D with cognitive impairment has not been explored to date. Vitamin D insufficiency has been associated with metabolic syndrome in psychotic disorders (Yoo et al, 2018), with insulin resistance (Garbossa and Folli, 2017), with thyroid dysfunction (Kim, 2017;Wang et al, 2018) and high vitamin D blood levels have been suggested to reduce peripheral low-grade inflammation (Zhu et al, 2015). There is a current debate on the association between alcohol use disorder and vitamin D deficiency (Tardelli et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

Fond

Godin

Schürhoff

et al. 2018

Psychiatry Research

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High levels of vitamin D in relation to reduced risk of schizophrenia with elevated C-reactive protein

Cited by 31 publications

References 33 publications

Assessment of Awareness, Knowledge, Attitude, and the Practice of Vitamin D among the General Public in Malaysia

Assessment of Awareness, Knowledge, Attitude, and the Practice of Vitamin D among the General Public in Malaysia

Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis, Schizophrenia, and Autism

Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

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