High levels of serum β2-microglobulin predict severity of coronary artery disease

Abstract

BackgroundThe identification of new risk factors for coronary artery disease (CAD) is increasingly sought in an effort to tackle this threatening disease. β2-microglobulin (B2M) is reported to associate with peripheral arterial disease and adverse cardiovascular outcomes. However, the association between B2M and cardiovascular disease remains under-researched. This study evaluated the effects of B2M on CAD without renal dysfunction.MethodsOne thousand seven hundred sixty-two subjects (403 non-CAD subjects and 1,359 CAD subjects) were investigated. Fasting samples were collected to determine B2M level. The Gensini and SYNTAX scores were used to assess the severity of CAD.ResultsCAD subjects were significantly higher in serum B2M level comparing with non-CAD subjects (1.25 ± 0.46 vs 1.14 ± 0.28 mg/L, p < 0.001). Serum B2M level was a risk factor of CAD after adjusting potential confounders (Odds Ratio (OR) = 2.363, 95% confidence interval (CI): 1.467–3.906, p = 0.001). Receiver operating characteristics (ROC) showed B2M level moderately predicted diagnosis of CAD (the area under the ROC curve (AUC) = 0.608, 95% CI: 0.577–0.639, p < 0.001). Furthermore, serum B2M level was positively associated with Gensini score system, SYNTAX score system and the number of disease vessels (NDV ≥ 2).ConclusionsThe significant association between serum B2M and CAD suggests that B2M could be a biomarker for CAD.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-017-0502-9) contains supplementary material, which is available to authorized users.

Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

“…For example, we found decreased SH2B3 expression to be causal for higher circulating B2M levels. This extends prior knowledge of the associations of SH2B3 24 and B2M 25 with hypertension as we demonstrate a unidirectional causal association between SH2B3 expression and plasma B2M levels, and thus provide plausible evidence for a causal role of the SH2B3 -B2M axis in hypertension (Supplementary Fig. 2b ).…”

Serum β2-Microglobulin Is Closely Associated With the Recurrence Risk and 3-Month Outcome of Acute Ischemic Stroke

“…As a novel biological marker associated with inflammation, β2M has been studied extensively in autoimmune diseases, cancer, infection, kidney disease, peripheral artery disease, and cardiovascular disease (CVD) (20,21). More importantly, β2M is a potential initiator that promotes the development of an inflammatory reaction (8).…”

IRF1-mediated downregulation of PGC1α contributes to cardiorenal syndrome type 4

“…Several water-soluble toxins have emerged as hallmarks of CKD 12 , 13 and risk factors for CVD in CKD patients 14 , such as high phosphate (HP), fibroblast growth factor 23 (FGF23), and trimethylamine- N -oxide (TMAO). Middle-molecules can be used to predict the severity of coronary artery disease, such as β2-microglobulin (B2M) 15 . Protein-bound toxins are associated with CKD progression and increased cardiovascular mortality, such as Indoxyl sulfate (IS) and p -cresyl sulfate (PCS) 16 .…”