1991
DOI: 10.1007/bf00261685
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High levels of recombination induced by homologous P elements in Drosophila melanogaster

Abstract: P element transposons in Drosophila melanogaster are capable of mobilizing incomplete P elements elsewhere in the genome, and of inducing recombination. This recombination is usually only of the order of 1% or less. We show that two P elements, located at exactly homologous sites, induce levels of recombination of 20% or higher. The recombination appears to be exact, as determined by the lack of phenotypic effects in recombinant products and the lack of size changes detectable by Southern hybridization. Female… Show more

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Cited by 37 publications
(32 citation statements)
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“…The results are consistent with the previous conclusion (18) that strand exchange does not occur in most gap-repair events. However, the data cannot rule out the possibility that there is a small amount of crossing over in order to explain the enhanced male recombination seen at P element-containing intervals (27,28). Mismatches of each whd-R allele used and corresponding reversion rates.…”
Section: Experiments and Resultsmentioning
confidence: 96%
“…The results are consistent with the previous conclusion (18) that strand exchange does not occur in most gap-repair events. However, the data cannot rule out the possibility that there is a small amount of crossing over in order to explain the enhanced male recombination seen at P element-containing intervals (27,28). Mismatches of each whd-R allele used and corresponding reversion rates.…”
Section: Experiments and Resultsmentioning
confidence: 96%
“…Production of the ring-X chromosome containing the P element: Female recombination in the absence of transposase was used to recombine the P element from the rod-X chromosome containing a P[CaSpeR] insertion at 17C (Ca120.10; see Sved et al 1990) to the ring-X chromosome. Male progeny of female flies heterozygous for the ring-X chromosome and for the Ca120.10 chromosome were screened (Figure 1).…”
Section: Stocks Usedmentioning
confidence: 99%
“…P elements induce male recombination at a low rate in crosses between wild and laboratory strains of Drosophila melanogaster (Hiraizumi 1971). Comparable levels of recombination can be produced by a single incomplete P element when activated by a transposase source (Sved et al 1990). Furthermore, the level of recombination rises from ,1% to 20% if P elements are present at homologous sites on the two chromosomes (Sved et al 1991).…”
Section: Introductionmentioning
confidence: 99%
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“…The results from combinations of elements (classes (3)-(11) of Figure 4) reveal that with two exceptions, the rates of recombination are in the range 13-20%, comparable to that given by homologous unaltered elements (Sved et al, 1991). The exceptions, classes (4) and (7), are in the range 5-6%.…”
Section: Discussionmentioning
confidence: 85%