High Levels of Psychological Distress, Sleep Disturbance, and Alcohol Use Disorder in Adults With Atopic Dermatitis

Gilhooley, Eimear; O’Grady, Ciara; Roche, Darren; Mahon, Julie Mac; Hambly, Róisín; Kelly, A.; Dhonncha, Eilis Nic; Moriarty, B.; Connolly, Maureen; Kirby, Brian; Tobin, Anne‐Marie; Ryan, Caitriona

doi:10.1097/der.0000000000000687

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…Likewise, our research found that, in ESRD patients, a diagnosis of alcohol dependence was associated with an increased risk of AD. In a study of 100 patients, 25% of those with moderate to severe AD met criteria for an alcohol-use disorder [48]. Alcohol has been found to induce a primarily Th2-focused response in the immune system and to increase IgE levels [49], which may explain the increased risk of AD observed here.…”

Section: Demographic and Other Clinical Risk Factorsmentioning

confidence: 64%

Atopic Dermatitis and the Risk of Infection in End-Stage Renal Disease

Momin,

Baer,

Waller

et al. 2023

Medicina

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Background and Objectives: Atopic dermatitis (AD), also known as eczema, is a common chronic inflammatory skin condition affecting 16.5 million adults in the United States. AD is characterized by an impaired epidermal barrier that can predispose individuals to infection. End-stage renal disease (ESRD) is also commonly complicated by infections due to chronic vascular access and immune-system dysfunction, possibly related to uremia. Multiple studies have reported that renal disease is a common comorbidity in adults with atopic dermatitis. The aim of this study was to determine whether AD is a risk factor for certain infections in patients with ESRD. Materials and Methods: Using the United States Renal Data System, a retrospective cohort analysis was conducted on adult ESRD patients initiating dialysis between 2004 and 2019 to investigate associations between infections and AD in this population. Results: Of 1,526,266 patients, 2290 were identified with AD (0.2%). Infectious outcomes of interest were bacteremia, septicemia, cellulitis, herpes zoster, and conjunctivitis. In all infectious outcomes except for conjunctivitis, patients with the infectious outcomes were more likely to carry a diagnosis of AD. After controlling for demographic and clinical covariates, AD was associated with an increased risk of cellulitis (adjusted relative risk (aRR) = 1.39, 95% confidence interval (CI) = 1.31–1.47) and herpes zoster (aRR = 1.67, CI = 1.44–1.94), but not with bacteremia (aRR = 0.96, CI = 0.89–1.05), septicemia (aRR = 1.02, CI = 0.98–1.08), or conjunctivitis (aRR = 0.97, CI = 0.740–1.34). Conclusions: Overall, after controlling for demographic and clinical covariates and adjusting for person-years-at-risk, AD was associated with an increased risk for some, but not all, infections within the population of patients with ESRD.

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Section: Demographic and Other Clinical Risk Factorsmentioning

confidence: 64%

Atopic Dermatitis and the Risk of Infection in End-Stage Renal Disease

Momin,

Baer,

Waller

et al. 2023

Medicina

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“…Atopic dermatitis (AD) is characterized by chronic eczematous eruptions with flares, significant pruritus and profound impact on quality of life. [9][10][11] Although the visibility of clinical signs can be used to define the severity of skin diseases, clinician-determined severity may not reflect the impact of the disease on patients' quality of life. 12,13 Moreover, evaluation of therapeutic success relying merely on skin examination may unsatisfactorily address patient-related needs and symptoms, 14 with potentially significant discordance between patients and physicians in disease severity assessments, 15,16 especially in patients with depression and anxiety.…”

Section: Introductionmentioning

confidence: 99%

“…Atopic dermatitis (AD) is characterized by chronic eczematous eruptions with flares, significant pruritus and profound impact on quality of life 9–11 . Although the visibility of clinical signs can be used to define the severity of skin diseases, clinician‐determined severity may not reflect the impact of the disease on patients' quality of life 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Treat‐to‐target in dermatology: A scoping review and International Eczema Council survey on the approach in atopic dermatitis

Renert‐Yuval,

Del Duca,

Arents

et al. 2023

Acad Dermatol Venereol

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Treat‐to‐Target (T2T) is a pragmatic therapeutic strategy being gradually introduced into dermatology after adoption in several other clinical areas. Atopic dermatitis (AD), one of the most common inflammatory skin diseases, may also benefit from this structured and practical therapeutic approach. We aimed to evaluate existing data regarding the T2T approach in dermatology, with a specific focus on AD, as well as the views of International Eczema Council (IEC) members on the potential application of a T2T approach to AD management. To do so, we systematically searched for peer‐reviewed publications on the T2T approach for any skin disease in the PubMed and Scopus databases up to February 2022 and conducted a survey among IEC members regarding various components to potentially include in a T2T approach in AD.We identified 21 relevant T2T‐related reports in dermatology, of which 14 related to psoriasis, five to AD, one for juvenile dermatomyositis and one for urticaria. In the IEC member survey, respondents proposed treatable traits (with itch, disease severity, and sleep problems getting the highest scores), relevant comorbidities (with asthma being selected most commonly, followed by anxiety and depression in adults), recommended specialists that should define the approach in AD (dermatologists, allergists, and primary care physicians were most commonly selected in adults), and applicable assessment tools (both physician‐ and patient‐reported), in both adult and pediatric patients, for potential future utilization of the T2T approach in AD.In conclusion, while the T2T approach may become a useful tool to simplify therapeutic goals and AD management, its foundation in AD is only starting to build. A multidisciplinary approach, including a wide range of stakeholders, including patients, is needed to further define the essential components needed to utilize T2T in AD.

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“…The burden of skin diseases such as AD is well documented, in addition to physical discomfort, AD patients suffer considerable social and psychological repercussions, so their quality of life is significantly diminished. [1][2][3] Indeed, Beattie and Lewis-Jones have shown that AD was among the chronic diseases in children that had a major negative influence on their quality of life. 4 Furthermore, it is known that AD can persist into adulthood, or the onset of disease can occur later in life.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the breaking points in the global care pathway of patients with atopic dermatitis

Aroman

Carballido

Jean‐Decoster

et al. 2023

JEADV Clinical Practice

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Background Atopic dermatitis (AD) is a chronic pruritic skin disease with flare‐ups. All age groups can be affected. The quality of life of AD patients can be altered if their medical follow‐up is not optimal. Objectives The aim of this study is to identify the breakpoints in the care pathway for patients with atopic dermatitis. Methods We carried out an analysis of care pathways based on responses from healthcare professionals and patients with AD using anonymized questionnaires designed by a steering committee of expert patients and health care professionals. Results At the end of this survey, we collected 260 responses to the questionnaires from the patients and 57 responses from the healthcare professionals. Three break points were identified. Firstly, a large majority of patients admitted to not having enough social support and especially paramedical support. The second breaking point is patient compliance with treatment. 20% of patients discontinue their treatment, and a vast majority express a lack of information about their disease. The last point of rupture between patients and healthcare professionals is the appointment for their initial consultation; delays are underestimated or under‐reported by practitioners. Conclusions This study shows that some points need to be improved in the patient care process on both sides, patients, and health professional. A dialogue between the two parts should be open to focus on solutions to improve the care pathway of patients with AD.

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High Levels of Psychological Distress, Sleep Disturbance, and Alcohol Use Disorder in Adults With Atopic Dermatitis

Cited by 6 publications

References 30 publications

Atopic Dermatitis and the Risk of Infection in End-Stage Renal Disease

Atopic Dermatitis and the Risk of Infection in End-Stage Renal Disease

Treat‐to‐target in dermatology: A scoping review and International Eczema Council survey on the approach in atopic dermatitis

Evaluation of the breaking points in the global care pathway of patients with atopic dermatitis

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