High levels of plasma selenium are associated with metabolic syndrome and elevated fasting plasma glucose in a Chinese population: A case-control study

Correlates of toenail selenium and its cross‐sectional association with metabolic syndrome

“…In a French study conducted on 5220 men and women over a 7.5‐year period, there was no correlation between serum selenium levels and the prevalence of metabolic syndrome, which is consistent with the results of the present study . By contrast, other studies in Europe and China have reported different results depending on sex . Arnaud et al .…”

“…In the present study, no significant relationship was observed between toenail selenium levels and the prevalence of metabolic syndrome and its components. To date, the literature has reported inconsistent results regarding the association between selenium level and metabolic syndrome ( . In a French study conducted on 5220 men and women over a 7.5‐year period, there was no correlation between serum selenium levels and the prevalence of metabolic syndrome, which is consistent with the results of the present study .…”

“…Multivariable logistic regression analyses were used to estimate ORs and 95% confidence intervals (CIs) for the associations of toenail selenium levels with metabolic syndrome and its components. Potential confounding factors that could affect the associations were selected based on preliminary analyses and previous studies ( . Possible effect modification was tested using multiplicative terms for multiple demographic and lifestyle variables, although no significant effect‐modification was identified.…”

“…Although numerous in vivo and in vitro studies have investigated the antioxidative effects of selenium, the results of epidemiological studies remain inconsistent across countries and regions, with some studies even suggesting that selenium increases the risk of chronic diseases . Few studies have examined the link between selenium and metabolic syndrome in Koreans, and research on the effects of long‐term selenium exposure remains limited.…”

The Effect of Selenium Supplementation on Glucose Homeostasis and the Expression of Genes Related to Glucose Metabolism

“…Results of this large and well-designed, randomized, placebo-controlled trial generated much controversy and up to now, no clear conclusion have been made with respect to the potentially diabetogenic properties of Se. Several observational studies, as well as Se supplementation trials, in which the association between Se status/Se intake and the risk of diabetes or markers of glucose metabolism has been investigated, generated inconsistent results [4,9,10,11,12]. On the other hand, animal studies indicated that Se supplementation may lead to hyperinsulinemia, insulin resistance, and glucose intolerance [13].…”