High levels of plasma brain natriuretic peptide and interleukin-6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality in patients with congestive heart failure

Maeda, Keiko; Tsutamoto, Takayoshi; Wada, Atsuyuki; Mabuchi, Naoko; Hayashi, Meiso; Tsutsui, Takashi; Ohnishi, Masato; Sawaki, Masahide; Fujii, Masazumi; Matsumoto, Takehiro; Kinoshita, Masahiko

doi:10.1016/s0735-1097(00)00912-8

Cited by 375 publications

(284 citation statements)

References 33 publications

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“…This finding is in line with an earlier report in acute HF patients, in which levels of BNP measured at admission were found to hold equal predictive value for in‐hospital mortality and length of stay 12. Additionally, several key studies have evaluated the predictive value of BNP in Asian populations and showed that BNP is a key predictor of outcomes in these patients 30, 31, 32. Also, NT‐proBNP levels had equal predictive value in both HFpEF and HFrEF.…”

Section: Discussionsupporting

confidence: 89%

N‐terminal pro‐B‐type natriuretic peptide and prognosis in Caucasian vs. Asian patients with heart failure

et al. 2018

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AimsN‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) is the most frequently used biomarker in heart failure (HF), but its prognostic utility across ethnicities is unclear.Methods and resultsThis study included 546 Caucasians with HF from the Coordinating Study Evaluating Outcomes of Advising and Counseling in Heart Failure and 578 Asians with HF from the Singapore Heart Failure Outcomes and Phenotypes study. NT‐proBNP was measured at discharge after HF hospitalization. The studied outcome was a composite of all‐cause mortality and HF hospitalization at 18 months. Compared with Caucasian patients, Asian patients were younger (63 ± 12 vs. 71 ± 11 years); less often female (26% vs. 39%); and had lower body mass index (26 vs. 27 kg/m2), better renal function (61 ± 37 vs. 54 ± 20 mL/min/1.73 m2), lower rates of atrial fibrillation (25% vs. 46%), strikingly higher rates of diabetes (59% vs. 30%), and higher rates of hypertension (76% vs. 44%). Despite these clear inter‐group differences in individual drivers of NT‐proBNP, average levels were similar in Asians [2709 (1350, 6302) pg/mL] and Caucasians [2545 (1308, 5484) pg/mL] (P = 0.514). NT‐proBNP was strongly associated with outcome [hazard ratio 1.28 (per doubling), 95% confidence interval 1.18–1.39, P < 0.001], regardless of ethnicity (P interaction = 0.719). NT‐proBNP was similarly associated with outcome in HF with reduced and preserved ejection fraction in Asian (P interaction = 0.776) and Caucasian patients (P interaction = 0.558).ConclusionsNT‐proBNP has similar prognostic performance in Asians and Caucasians with HF despite ethnic differences in known clinical determinants of plasma NT‐proBNP.

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Section: Discussionsupporting

confidence: 89%

N‐terminal pro‐B‐type natriuretic peptide and prognosis in Caucasian vs. Asian patients with heart failure

et al. 2018

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“…IL-6 was found to predict long-term mortality 4,5,7 and long-term cardiac death 6 in chronic HF whereas, in the present study, IL-6 was not found to predict intermediateterm risk of ventricular arrhythmias among HF patients. Yet, none of the previous studies showed a correlation between IL-6 and sudden death, and the majority of the patients in the previous studies had NYHA class III-IV, whereas 81% of the patients in our study had NYHA class I-II.…”

Section: Il-6contrasting

confidence: 81%

“…So far, TNF-α was shown to predict cardiac mortality in patients with NYHA class III-IV, 6 and 1.1-2.7 years all cause mortality in stable HF patients and patients with NYHA III-IV. 7,20 These data together with the negative results of our study suggest that TNF-α may be related to nonarrhythmic death or may still be associated with arrhythmic death among unstable HF patients with NYHA III-IV.…”

Section: Tnf-αmentioning

confidence: 99%

“…3 Circulating levels of inflammatory cytokines have been shown to predict adverse outcome in HF patients. Increased plasma concentrations of interleukin-6 (IL-6), 4 -7 tumor necrosis alpha (TNF-α) 4,6,7 and Creactive protein (CRP) 8 -10 were all found to correlate with increased morbidity and mortality among patients with HF.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to these biomarkers, brain natriuretic peptide (BNP), released by ventricular cardiomyocytes in response to myocardial tension and increased intravascular volume, was consistently shown to predict poor outcome 6,11 including sudden death 12,13 among HF patients.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Biomarkers are not Predictive of Intermediate‐term Risk of Ventricular Tachyarrhythmias in Stable CHF Patients

Konstantino

Kusniec

Reshef

et al. 2007

Clinical Cardiology

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SummaryBackground: Elevated levels of inflammatory biomarkers and brain natriuretic peptide (BNP) are associated with increased mortality in patients with heart failure (HF).Hypothesis: The aim of the current study was to assess the correlation between circulating biomarkers and ventricular tachyarrhythmias among patients with HF.Methods: Blood samples from 50 stable ambulatory HF patients with moderate to severe systolic left ventricular (LV) dysfunction and an implantable cardioverter defibrillator (ICD) were analyzed for interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), high-sensitivity C-reactive protein (hsCRP) and BNP. Thereafter, the patients were followed for a mean period of 152 ± 44 days, during which ventricular tachyarrhythmias were recorded by the ICDs.Results: Follow-up data were obtained from 47 patients. Of them, 45 (96%) had ischemic cardiomyopathy, 38 (81%) had New York Heart Association class I-II, 43 (91%) were males, and the mean age was 68.6 ± 11.1 years. During follow-up, 5 patients (11%) had nonsustained ventricular tachycardia (NSVT), 6 patients (13%) had sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) and 36 patients

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Role of Erythropoietin in the Correction of Anemia in Patients with Heart Failure

Streeter¹,

Mancini²

2006

Heart Failure: Pharmacologic Management

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High levels of plasma brain natriuretic peptide and interleukin-6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality in patients with congestive heart failure

Cited by 375 publications

References 33 publications

N‐terminal pro‐B‐type natriuretic peptide and prognosis in Caucasian vs. Asian patients with heart failure

N‐terminal pro‐B‐type natriuretic peptide and prognosis in Caucasian vs. Asian patients with heart failure

Inflammatory Biomarkers are not Predictive of Intermediate‐term Risk of Ventricular Tachyarrhythmias in Stable CHF Patients

Role of Erythropoietin in the Correction of Anemia in Patients with Heart Failure

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